PMID- 36648605
OWN - NLM
STAT- MEDLINE
DCOM- 20230517
LR  - 20230603
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 19
IP  - 4
DP  - 2023 May
TI  - Combining Bone Collagen Material with hUC-MSCs for Applicationto Spina Bifida in 
      a Rabbit Model.
PG  - 1034-1050
LID - 10.1007/s12015-022-10478-x [doi]
AB  - Spina bifida is one of the neural tube defects, with a high incidence in human 
      birth defects, which seriously affects the health and quality of life of 
      patients. In the treatment of bone defects, the source of autologous bone is 
      limited and will cause secondary damage to the patient. At the same time, since 
      the bone tissue in animals needs to play a variety of biological functions, its 
      complex structure cannot be replaced by a single material. The combination of 
      mechanical materials and biological materials has become a common choice. Human 
      umbilical cord mesenchymal stem cells (hUC-MSCs) have the advantages of easy 
      access, rapid proliferation, low immunogenicity, and no ethical issues. It is 
      often used in the clinical research of tissue regeneration and repair. Therefore, 
      in this study, we established a spina bifida model using Japanese white rabbits. 
      This model was used to screen the best regenerative repair products for 
      congenital spina bifida, and to evaluate the safety of regenerative repair 
      products. The results showed that the combination of hUC-MSCs with collagen 
      material had better regeneration effect than collagen material alone, and had no 
      negative impact on the health of animals. This study provides a new idea for the 
      clinical treatment of spina bifida, and also helps to speed up the research 
      progress of regenerative repair products.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Wang, Hu
AU  - Wang H
AUID- ORCID: 0000-0002-7802-9167
AD  - Reproductive and Genetic Center, NHC Key Laboratory of Reproductive Health 
      Engineering Technology Research (NRIFP), National Research Institute for Family 
      Planning, Beijing, 100081, China.
AD  - Graduate Schools, Peking Union Medical College & Chinese Academy of Medical 
      Sciences, Beijing, 100730, China.
FAU - Sun, Xue-Cheng
AU  - Sun XC
AD  - Reproductive and Genetic Center, NHC Key Laboratory of Reproductive Health 
      Engineering Technology Research (NRIFP), National Research Institute for Family 
      Planning, Beijing, 100081, China.
AD  - Medical Genetics, Zibo Maternal and Child Health Hospital, Zibo, 255000, China.
FAU - Li, Jian-Hui
AU  - Li JH
AD  - Reproductive and Genetic Center, NHC Key Laboratory of Reproductive Health 
      Engineering Technology Research (NRIFP), National Research Institute for Family 
      Planning, Beijing, 100081, China.
FAU - Yin, Li-Qiang
AU  - Yin LQ
AD  - Yantai Zhenghai Bio-Tech Co., Ltd., Yantai, 264006, China.
FAU - Yan, Yu-Fang
AU  - Yan YF
AD  - Yantai Zhenghai Bio-Tech Co., Ltd., Yantai, 264006, China.
FAU - Ma, Xu
AU  - Ma X
AD  - Reproductive and Genetic Center, NHC Key Laboratory of Reproductive Health 
      Engineering Technology Research (NRIFP), National Research Institute for Family 
      Planning, Beijing, 100081, China. genetic@263.net.cn.
AD  - Graduate Schools, Peking Union Medical College & Chinese Academy of Medical 
      Sciences, Beijing, 100730, China. genetic@263.net.cn.
FAU - Xia, Hong-Fei
AU  - Xia HF
AD  - Reproductive and Genetic Center, NHC Key Laboratory of Reproductive Health 
      Engineering Technology Research (NRIFP), National Research Institute for Family 
      Planning, Beijing, 100081, China. hongfeixia@126.com.
AD  - Graduate Schools, Peking Union Medical College & Chinese Academy of Medical 
      Sciences, Beijing, 100730, China. hongfeixia@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230117
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Rabbits
MH  - Quality of Life
MH  - *Spinal Dysraphism/therapy
MH  - Collagen
MH  - *Mesenchymal Stem Cells
OTO - NOTNLM
OT  - Collagen material
OT  - Damage repair
OT  - Japanese white rabbits
OT  - MSCs
OT  - Spina bifida
EDAT- 2023/01/18 06:00
MHDA- 2023/05/17 06:42
CRDT- 2023/01/17 11:19
PHST- 2022/11/07 00:00 [accepted]
PHST- 2023/05/17 06:42 [medline]
PHST- 2023/01/18 06:00 [pubmed]
PHST- 2023/01/17 11:19 [entrez]
AID - 10.1007/s12015-022-10478-x [pii]
AID - 10.1007/s12015-022-10478-x [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2023 May;19(4):1034-1050. doi: 10.1007/s12015-022-10478-x. 
      Epub 2023 Jan 17.