PMID- 36650548
OWN - NLM
STAT- MEDLINE
DCOM- 20230119
LR  - 20230122
IS  - 1749-8090 (Electronic)
IS  - 1749-8090 (Linking)
VI  - 18
IP  - 1
DP  - 2023 Jan 17
TI  - Gender-related differences on outcome following transcatheter mitral valve repair 
      (TMVR): a systematic review and meta-analysis.
PG  - 31
LID - 10.1186/s13019-023-02123-6 [doi]
LID - 31
AB  - BACKGROUND: The effect of gender on patients with mitral valve regurgitation (MR) 
      undergoing transcatheter mitral valve repair (TMVR) remains to be defined. The 
      aim of the present study is a comprehensive meta-analysis of studies that 
      investigate differences between men and women after TMVR. METHODS: A systematic 
      literature search was carried out on eight databases to collect all relevant 
      studies on gender-related outcomes of TMVR before March 1, 2021. The main 
      outcomes of interest were mortality, cardiac function, MR class and other 
      complications. RESULTS: A total of eight literatures were included, all of which 
      were retrospective observational studies. Compared to women patients, men had 
      lower postoperative New York Heart Association (NYHA) class (OR = 1.53, 95%CI 
      [1.23, 1.91], P = 0.0001) and higher incidence of postoperative acute kidney 
      injury (AKI) (OR = 1.25, 95%CI [1.16, 1.34], P < 0.05). There were no significant 
      difference on mortality in 30 days (OR = 0.95, 95%CI [0.81, 1.11], P = 0.53) and 
      in 2 years (OR = 0.99, 95%CI [0.75, 1.30], P = 0.93), mitral valve regurgitation 
      (MR) class (OR = 1.30, 95%CI [0.97, 1.75], P = 0.08) and incidence of myocardial 
      infarction (MI) (OR = 0.88, 95%CI [0.65, 1.18], P = 0.38), stroke (OR = 0.80, 
      95%CI [0.63, 1.02], P = 0.08) and bleeding in hospital (OR = 0.84, 95%CI [0.59, 
      1.19], P = 0.32). CONCLUSIONS: Our meta-analysis demonstrates that men undergoing 
      TMVR have worse preoperative diseases (diabetes mellitus, coronary artery 
      disease, renal failure and myocardial infarction) while they have superior 
      postoperative NYHA class at one-year. There are no significantly difference in 
      other indexes between men and women.
CI  - (c) 2023. The Author(s).
FAU - Yi, Kang
AU  - Yi K
AD  - Department of Cardiovascular Surgery, Gansu Province, Gansu Provincial Hospital, 
      No. 204, Donggang West Road, Lanzhou, 730000, China.
AD  - Gansu International Scientific and Technological Cooperation Base of Diagnosis 
      and Treatment of Congenital Heart Disease, Lanzhou, China.
FAU - Gao, Jie
AU  - Gao J
AD  - Gansu International Scientific and Technological Cooperation Base of Diagnosis 
      and Treatment of Congenital Heart Disease, Lanzhou, China.
AD  - The First Clinical Medical College of Lanzhou University, Lanzhou, China.
AD  - Department of Pediatrics, First Affiliated Hospital of SunYat-sen University, 
      Guangzhou, China.
FAU - Wang, Wen-Xin
AU  - Wang WX
AD  - Gansu International Scientific and Technological Cooperation Base of Diagnosis 
      and Treatment of Congenital Heart Disease, Lanzhou, China.
AD  - The First Clinical Medical College of Gansu University of Chinese Medicine, 
      Lanzhou, China.
FAU - Ma, Yu-Hu
AU  - Ma YH
AD  - Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Cardiac Surgery, The First Hospital of China Medical University, 
      Shenyang, China.
FAU - He, Shao E
AU  - He SE
AD  - Gansu International Scientific and Technological Cooperation Base of Diagnosis 
      and Treatment of Congenital Heart Disease, Lanzhou, China.
AD  - The Second Clinical Medical College of Lanzhou University, Lanzhou, China.
FAU - Xu, Xiao-Min
AU  - Xu XM
AD  - Gansu International Scientific and Technological Cooperation Base of Diagnosis 
      and Treatment of Congenital Heart Disease, Lanzhou, China.
AD  - The First Clinical Medical College of Lanzhou University, Lanzhou, China.
AD  - Division of Gastroenterology, Seventh Affiliated Hospital of Sun Yat-Sen 
      University, Shenzhen, China.
FAU - Li, Peng-Fei
AU  - Li PF
AD  - Gansu International Scientific and Technological Cooperation Base of Diagnosis 
      and Treatment of Congenital Heart Disease, Lanzhou, China.
AD  - The First Clinical Medical College of Lanzhou University, Lanzhou, China.
FAU - You, Tao
AU  - You T
AD  - Department of Cardiovascular Surgery, Gansu Province, Gansu Provincial Hospital, 
      No. 204, Donggang West Road, Lanzhou, 730000, China. youtao2016@126.com.
AD  - Gansu International Scientific and Technological Cooperation Base of Diagnosis 
      and Treatment of Congenital Heart Disease, Lanzhou, China. youtao2016@126.com.
LA  - eng
GR  - GSWSKY2016-04/Health industry scientific research project of Gansu Province/
GR  - 21JR1RA027/Science Foundation of Gansu Province/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20230117
PL  - England
TA  - J Cardiothorac Surg
JT  - Journal of cardiothoracic surgery
JID - 101265113
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - *Mitral Valve Insufficiency
MH  - Mitral Valve/surgery
MH  - Treatment Outcome
MH  - *Heart Valve Prosthesis Implantation/adverse effects
MH  - Retrospective Studies
MH  - Cardiac Catheterization/adverse effects
MH  - *Myocardial Infarction/etiology
PMC - PMC9843892
OTO - NOTNLM
OT  - Gender differences
OT  - Meta-analysis
OT  - MitraClip
OT  - Mitral valve regurgitation
OT  - Systematic reviews
OT  - Transcatheter mitral valve repair
COIS- The authors declared that there have no competing interests.
EDAT- 2023/01/18 06:00
MHDA- 2023/01/20 06:00
PMCR- 2023/01/17
CRDT- 2023/01/17 23:33
PHST- 2022/04/13 00:00 [received]
PHST- 2023/01/02 00:00 [accepted]
PHST- 2023/01/17 23:33 [entrez]
PHST- 2023/01/18 06:00 [pubmed]
PHST- 2023/01/20 06:00 [medline]
PHST- 2023/01/17 00:00 [pmc-release]
AID - 10.1186/s13019-023-02123-6 [pii]
AID - 2123 [pii]
AID - 10.1186/s13019-023-02123-6 [doi]
PST - epublish
SO  - J Cardiothorac Surg. 2023 Jan 17;18(1):31. doi: 10.1186/s13019-023-02123-6.