PMID- 36652403
OWN - NLM
STAT- MEDLINE
DCOM- 20230619
LR  - 20240202
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 108
IP  - 7
DP  - 2023 Jun 16
TI  - HLA Class I Association With Autoimmune Diabetes in Chinese People: Distinct 
      Implications in Classic Type 1 Diabetes and LADA.
PG  - e404-e414
LID - 10.1210/clinem/dgad006 [doi]
AB  - CONTEXT: We aimed to investigate whether human leukocyte antigen (HLA) Class I 
      loci differentially modulated the risk for and clinical features of Chinese 
      people with classic type 1 diabetes (T1D) and latent autoimmune diabetes in 
      adults (LADA). METHODS: In this case-control study, genotypes of HLA-A, -B, -C, 
      -DRB1, -DQA1, and -DQB1 loci were obtained from 1067 cases with classic T1D, 1062 
      cases with LADA, and 1107 normal controls using next-generation sequencing. 
      RESULTS: Despite 4 alleles shared between classic T1D and LADA (protective: 
      A*02:07 and B*46:01; susceptible: B*54:01 and C*08:01), 7 Class I alleles 
      conferred risk exclusively for classic T1D (A*24:02, B*15:02, B*15:18, B*39:01, 
      B*40:06, B*48:01, and C*07:02) whereas only A*02:01 was an additional risk factor 
      for LADA. Class I alleles affected a wide spectrum of T1D clinical features, 
      including positive rate of protein tyrosine phosphatase autoantibody and zinc 
      transporter 8 autoantibody (A*24:02), C-peptide levels (A*24:02), and age at 
      diagnosis (B*46:01, C*01:02, B*15:02, C*07:02, and C*08:01). By contrast, except 
      for the detrimental effect of C*08:01 on C-peptide concentrations in LADA, no 
      other Class I associations with clinical characteristics of LADA could be 
      reported. The addition of Class I alleles refined the risk model consisting only 
      of DR-DQ data in classic T1D while the overall predictive value of the LADA risk 
      model comprising both Class I and II information was relatively low. CONCLUSION: 
      The attenuated HLA Class I susceptibility to LADA was indicative of a less 
      deleterious immunogenetic nature compared with classic T1D. These autoimmune 
      diabetes-related Class I variants might serve as additional markers in future 
      screening among Chinese people.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      Endocrine Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Xia, Ying
AU  - Xia Y
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha 410011, Hunan, China.
FAU - Chen, Yan
AU  - Chen Y
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha 410011, Hunan, China.
FAU - Li, Xia
AU  - Li X
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha 410011, Hunan, China.
FAU - Luo, Shuoming
AU  - Luo S
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha 410011, Hunan, China.
FAU - Lin, Jian
AU  - Lin J
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha 410011, Hunan, China.
FAU - Huang, Gan
AU  - Huang G
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha 410011, Hunan, China.
FAU - Xiao, Yang
AU  - Xiao Y
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha 410011, Hunan, China.
FAU - Chen, Zhiying
AU  - Chen Z
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha 410011, Hunan, China.
FAU - Xie, Zhiguo
AU  - Xie Z
AUID- ORCID: 0000-0001-5037-3807
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha 410011, Hunan, China.
FAU - Zhou, Zhiguang
AU  - Zhou Z
AUID- ORCID: 0000-0002-0374-1838
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha 410011, Hunan, China.
LA  - eng
SI  - figshare/10.6084/m9.figshare.14377001
GR  - 81820108007/National Natural Science Foundation of China/
GR  - 2018YFE0114500/National Key R&D Program of China/
GR  - 2022JJ30858/Hunan Province Natural Science Foundation of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (C-Peptide)
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Diabetes Mellitus, Type 1/epidemiology/genetics
MH  - *Latent Autoimmune Diabetes in Adults
MH  - Case-Control Studies
MH  - C-Peptide
MH  - East Asian People
MH  - Genetic Predisposition to Disease
MH  - Autoantibodies/genetics
OTO - NOTNLM
OT  - Chinese
OT  - HLA
OT  - genetics
OT  - latent autoimmune diabetes in adults
OT  - type 1 diabetes
EDAT- 2023/01/19 06:00
MHDA- 2023/06/19 13:08
CRDT- 2023/01/18 13:32
PHST- 2022/10/25 00:00 [received]
PHST- 2023/06/19 13:08 [medline]
PHST- 2023/01/19 06:00 [pubmed]
PHST- 2023/01/18 13:32 [entrez]
AID - 6991313 [pii]
AID - 10.1210/clinem/dgad006 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2023 Jun 16;108(7):e404-e414. doi: 
      10.1210/clinem/dgad006.