PMID- 36653335 OWN - NLM STAT- MEDLINE DCOM- 20230120 LR - 20240322 IS - 2158-3188 (Electronic) IS - 2158-3188 (Linking) VI - 13 IP - 1 DP - 2023 Jan 19 TI - Cortical connectomic mediations on gamma band synchronization in schizophrenia. PG - 13 LID - 10.1038/s41398-022-02300-6 [doi] LID - 13 AB - Aberrant gamma frequency neural oscillations in schizophrenia have been well demonstrated using auditory steady-state responses (ASSR). However, the neural circuits underlying 40 Hz ASSR deficits in schizophrenia remain poorly understood. Sixty-six patients with schizophrenia spectrum disorders and 85 age- and gender-matched healthy controls completed one electroencephalography session measuring 40 Hz ASSR and one imaging session for resting-state functional connectivity (rsFC) assessments. The associations between the normalized power of 40 Hz ASSR and rsFC were assessed via linear regression and mediation models. We found that rsFC among auditory, precentral, postcentral, and prefrontal cortices were positively associated with 40 Hz ASSR in patients and controls separately and in the combined sample. The mediation analysis further confirmed that the deficit of gamma band ASSR in schizophrenia was nearly fully mediated by three of the rsFC circuits between right superior temporal gyrus-left medial prefrontal cortex (MPFC), left MPFC-left postcentral gyrus (PoG), and left precentral gyrus-right PoG. Gamma-band ASSR deficits in schizophrenia may be associated with deficient circuitry level connectivity to support gamma frequency synchronization. Correcting gamma band deficits in schizophrenia may require corrective interventions to normalize these aberrant networks. CI - (c) 2023. The Author(s). FAU - Du, Xiaoming AU - Du X AUID- ORCID: 0000-0001-7206-5282 AD - Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. xdu@som.umaryland.edu. FAU - Hare, Stephanie AU - Hare S AUID- ORCID: 0000-0002-7350-0351 AD - Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. FAU - Summerfelt, Ann AU - Summerfelt A AD - Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. FAU - Adhikari, Bhim M AU - Adhikari BM AD - Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. FAU - Garcia, Laura AU - Garcia L AD - Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. FAU - Marshall, Wyatt AU - Marshall W AUID- ORCID: 0000-0002-6661-3833 AD - Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. FAU - Zan, Peng AU - Zan P AD - Department of Electrical & Computer Engineering, University of Maryland, College Park, MD, USA. FAU - Kvarta, Mark AU - Kvarta M AUID- ORCID: 0000-0002-1093-1648 AD - Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. FAU - Goldwaser, Eric AU - Goldwaser E AD - Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. FAU - Bruce, Heather AU - Bruce H AUID- ORCID: 0000-0001-5630-3041 AD - Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. FAU - Gao, Si AU - Gao S AUID- ORCID: 0000-0002-4473-1142 AD - Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. FAU - Sampath, Hemalatha AU - Sampath H AD - Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. FAU - Kochunov, Peter AU - Kochunov P AD - Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. FAU - Simon, Jonathan Z AU - Simon JZ AUID- ORCID: 0000-0003-0858-0698 AD - Department of Electrical & Computer Engineering, University of Maryland, College Park, MD, USA. AD - Department of Biology, University of Maryland, College Park, MD, USA. AD - Institute for Systems Research, University of Maryland, College Park, MD, USA. FAU - Hong, L Elliot AU - Hong LE AD - Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. LA - eng GR - UH3 DA047685/DA/NIDA NIH HHS/United States GR - R01 DC014085/DC/NIDCD NIH HHS/United States GR - R01 MH116948/MH/NIMH NIH HHS/United States GR - T32 MH067533/MH/NIMH NIH HHS/United States GR - RF1 MH123163/MH/NIMH NIH HHS/United States GR - P50 MH103222/MH/NIMH NIH HHS/United States GR - R01 EB015611/EB/NIBIB NIH HHS/United States GR - S10 OD023696/OD/NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20230119 PL - United States TA - Transl Psychiatry JT - Translational psychiatry JID - 101562664 SB - IM MH - Humans MH - *Schizophrenia MH - Evoked Potentials, Auditory/physiology MH - Acoustic Stimulation/methods MH - *Connectome MH - *Auditory Cortex MH - Electroencephalography/methods PMC - PMC9849210 COIS- The authors declare no competing interests. EDAT- 2023/01/19 06:00 MHDA- 2023/01/21 06:00 PMCR- 2023/01/19 CRDT- 2023/01/18 23:12 PHST- 2019/08/12 00:00 [received] PHST- 2022/12/22 00:00 [accepted] PHST- 2022/12/07 00:00 [revised] PHST- 2023/01/18 23:12 [entrez] PHST- 2023/01/19 06:00 [pubmed] PHST- 2023/01/21 06:00 [medline] PHST- 2023/01/19 00:00 [pmc-release] AID - 10.1038/s41398-022-02300-6 [pii] AID - 2300 [pii] AID - 10.1038/s41398-022-02300-6 [doi] PST - epublish SO - Transl Psychiatry. 2023 Jan 19;13(1):13. doi: 10.1038/s41398-022-02300-6.