PMID- 36653888
OWN - NLM
STAT- MEDLINE
DCOM- 20230323
LR  - 20240215
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Print)
IS  - 2233-6079 (Linking)
VI  - 47
IP  - 2
DP  - 2023 Mar
TI  - Non-Alcoholic Fatty Liver Disease with Sarcopenia and Carotid Plaque Progression 
      Risk in Patients with Type 2 Diabetes Mellitus.
PG  - 232-241
LID - 10.4093/dmj.2021.0355 [doi]
AB  - BACKGROUND: We aimed to evaluate whether non-alcoholic fatty liver disease 
      (NAFLD) with or without sarcopenia is associated with progression of carotid 
      atherosclerosis in patients with type 2 diabetes mellitus (T2DM). METHODS: We 
      investigated 852 T2DM patients who underwent abdominal ultrasonography, 
      bioelectrical impedance analysis, and carotid artery ultrasonography at baseline 
      and repeated carotid ultrasonography after 6 to 8 years. NAFLD was confirmed by 
      abdominal ultrasonography, and sarcopenia was defined as a sex-specific skeletal 
      muscle mass index (SMI) value <2 standard deviations below the mean for healthy 
      young adults. SMI was calculated by dividing the sum of appendicular skeletal 
      mass by body weight. We investigated the association between NAFLD with or 
      without sarcopenia and the progression of carotid atherosclerosis. RESULTS: Of 
      the 852 patients, 333 (39.1%) were classified as NAFLD without sarcopenia, 66 
      (7.7%) were classified as sarcopenia without NAFLD, and 123 (14.4%) had NAFLD 
      with sarcopenia at baseline. After 6 to 8 years, patients with both NAFLD and 
      sarcopenia had a higher risk of atherosclerosis progression (adjusted odds ratio, 
      2.20; P<0.009) than controls without NAFLD and sarcopenia. When a subgroup 
      analysis was performed on only patients with NAFLD, female sex, absence of 
      central obesity, and non-obesity were significant factors related to increased 
      risk of plaque progression risk in sarcopenic patients. CONCLUSION: NAFLD with 
      sarcopenia was significantly associated with the progression of carotid 
      atherosclerosis in T2DM patients.
FAU - Cho, Yongin
AU  - Cho Y
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha 
      University College of Medicine, Incheon, Korea.
FAU - Park, Hye-Sun
AU  - Park HS
AD  - Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Huh, Byung Wook
AU  - Huh BW
AD  - Huh's Diabetes Center and the 21st Century Diabetes and Vascular Research 
      Institute, Seoul, Korea.
FAU - Lee, Yong-Ho
AU  - Lee YH
AD  - Department of Internal Medicine, Yonsei University College of Medicine, Seoul, 
      Korea.
FAU - Seo, Seong Ha
AU  - Seo SH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha 
      University College of Medicine, Incheon, Korea.
FAU - Seo, Da Hea
AU  - Seo DH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha 
      University College of Medicine, Incheon, Korea.
FAU - Ahn, Seong Hee
AU  - Ahn SH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha 
      University College of Medicine, Incheon, Korea.
FAU - Hong, Seongbin
AU  - Hong S
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha 
      University College of Medicine, Incheon, Korea.
FAU - Kim, So Hun
AU  - Kim SH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha 
      University College of Medicine, Incheon, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230119
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - *Non-alcoholic Fatty Liver Disease/complications/diagnostic imaging/epidemiology
MH  - *Sarcopenia/complications/diagnostic imaging/epidemiology
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - *Plaque, Atherosclerotic/complications/diagnostic imaging/epidemiology
MH  - *Carotid Artery Diseases/complications/diagnostic imaging/epidemiology
PMC - PMC10040622
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Diabetes mellitus, type 2
OT  - Fatty liver
OT  - Sarcopenia
COIS- CONFLICTS OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2023/01/19 06:00
MHDA- 2023/03/24 06:00
PMCR- 2023/03/01
CRDT- 2023/01/18 23:41
PHST- 2021/12/15 00:00 [received]
PHST- 2022/03/18 00:00 [accepted]
PHST- 2023/01/19 06:00 [pubmed]
PHST- 2023/03/24 06:00 [medline]
PHST- 2023/01/18 23:41 [entrez]
PHST- 2023/03/01 00:00 [pmc-release]
AID - dmj.2021.0355 [pii]
AID - dmj-2021-0355 [pii]
AID - 10.4093/dmj.2021.0355 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2023 Mar;47(2):232-241. doi: 10.4093/dmj.2021.0355. Epub 2023 
      Jan 19.