PMID- 36654568
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230120
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 14
IP  - 12
DP  - 2022 Dec
TI  - Successful Third Kidney Transplantation in a Nigerian Kidney Transplant Center: A 
      Case Report.
PG  - e32521
LID - 10.7759/cureus.32521 [doi]
LID - e32521
AB  - Patients with end-stage renal disease have limited options in the course of their 
      management. Kidney transplantation (KT) remains the gold standard for the 
      management of renal replacement therapy. There is increasing evidence supporting 
      the viability of third and fourth KTs. Due to the complexities of carrying out a 
      successful third KT and the scarcity of living organ donors, it is not a common 
      procedure in Nigeria's few renal transplant centres. To date, there is no 
      reported case of a successful third KT in Nigeria. Here, we present the first 
      reported case of a third KT carried out in Nigeria on a 44-year-old hypertensive, 
      hepatitis B-infected, non-diabetic male patient. He had the first living donor KT 
      eight years ago, which he lost due to poor immunosuppressive medication 
      adherence. He then had a second living donor, KT, four years ago. Both KTs were 
      from altruistic donors and were performed in the same hospital outside Nigeria. 
      He developed allograft nephropathy after receiving the AstraZeneca COVID-19 
      vaccine 16 months ago and lost the second graft as a result. He was worked up and 
      transplanted at our centre. Third kidney transplantation can be performed 
      successfully despite the challenges of human leukocyte antigen (HLA) 
      sensitization, antibiotic resistance, and surgical placement of the graft.
CI  - Copyright (c) 2022, Olatise et al.
FAU - Olatise, Olalekan O
AU  - Olatise OO
AD  - Department of Medicine/Nephrology Unit, Zenith Medical and Kidney Centre, Abuja, 
      NGA.
FAU - Asaolu, Stephen O
AU  - Asaolu SO
AD  - Department of Clinical Research, Zenith Medical and Kidney Centre, Abuja, NGA.
FAU - Muoka, Michael O
AU  - Muoka MO
AD  - Department of Clinical Research, Zenith Medical and Kidney Centre, Abuja, NGA.
FAU - Faponle, Adegboyega E
AU  - Faponle AE
AD  - Department of Medicine/Nephrology Unit, Zenith Medical and Kidney Centre, Abuja, 
      NGA.
FAU - Igbokwe, Martin C
AU  - Igbokwe MC
AD  - Department of Surgery, Urology Unit, Zenith Medical and Kidney Centre, Abuja, 
      NGA.
FAU - Anosike, Ikechukwu
AU  - Anosike I
AD  - Department of Surgery, Urology Unit, Zenith Medical and Kidney Centre, Abuja, 
      NGA.
FAU - Onwuasoanya, Uzodimma E
AU  - Onwuasoanya UE
AD  - Department of Surgery, Urology Unit, Zenith Medical and Kidney Centre, Abuja, 
      NGA.
FAU - Olatise, Adaku T
AU  - Olatise AT
AD  - Department of Medicine, Zenith Medical and Kidney Centre, Abuja, NGA.
FAU - Vasanth, Kumar R
AU  - Vasanth KR
AD  - Department of Surgery, Urology Unit, Zenith Medical and Kidney Centre, Abuja, 
      NGA.
LA  - eng
PT  - Case Reports
DEP - 20221214
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9838681
OTO - NOTNLM
OT  - challenges
OT  - covid-19 vaccine
OT  - desensitization
OT  - kidney transplantation
OT  - third
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/01/20 06:00
MHDA- 2023/01/20 06:01
PMCR- 2022/12/14
CRDT- 2023/01/19 01:53
PHST- 2022/12/14 00:00 [accepted]
PHST- 2023/01/19 01:53 [entrez]
PHST- 2023/01/20 06:00 [pubmed]
PHST- 2023/01/20 06:01 [medline]
PHST- 2022/12/14 00:00 [pmc-release]
AID - 10.7759/cureus.32521 [doi]
PST - epublish
SO  - Cureus. 2022 Dec 14;14(12):e32521. doi: 10.7759/cureus.32521. eCollection 2022 
      Dec.