PMID- 36655490
OWN - NLM
STAT- MEDLINE
DCOM- 20230331
LR  - 20230331
IS  - 1525-1470 (Electronic)
IS  - 0736-8046 (Linking)
VI  - 40
IP  - 2
DP  - 2023 Mar
TI  - Elevated serum total IgE is associated with eczema exacerbation in children 
      hospitalized for atopic dermatitis.
PG  - 301-304
LID - 10.1111/pde.15245 [doi]
AB  - BACKGROUND/OBJECTIVES: Atopic dermatitis (AD) can be a debilitating skin 
      condition, often leading to hospitalization due to severe AD exacerbations or 
      infectious complications. As both AD exacerbations and infectious complications 
      can present similarly, it can be difficult to distinguish the two conditions. 
      Thus, we aimed to evaluate if there is any difference in serum IgE levels in 
      children with AD who were hospitalized for AD exacerbation and for AD-associated 
      infectious complications. METHODS: A retrospective chart review was performed on 
      hospitalized children with AD exacerbations and AD-associated infectious 
      complications over a 17-year span. Data including length of stay, primary 
      diagnosis, systemic antibiotics, laboratory, and bacterial culture results were 
      collected. Serum total immunoglobulin E (IgE) levels were adjusted by age. Age, 
      length of stay, total IgE levels, and age-adjusted IgE levels were compared using 
      t-test. Logistic regression was used for age-adjusted IgE levels. RESULTS: The 
      mean serum total IgE level in subjects with AD exacerbation was 9603 +/- 15,873 
      kU/L, which was significantly higher than that of subjects with infectious 
      complications at 3167 +/- 5486 kU/L (p = .029). Logistic regression revealed that 
      subjects with an age-adjusted IgE of >4 had more than 3-fold odds of having AD 
      exacerbation than infectious complications. CONCLUSIONS: Our results suggest that 
      total IgE levels are higher in children who were hospitalized for AD exacerbation 
      than those with AD-associated infectious complications.
CI  - (c) 2023 The Authors. Pediatric Dermatology published by Wiley Periodicals LLC.
FAU - Atwal, Sanmeet
AU  - Atwal S
AD  - School of Medicine, University of Southern California, Los Angeles, California, 
      USA.
FAU - Ong, Peck Y
AU  - Ong PY
AUID- ORCID: 0000-0002-6664-463X
AD  - School of Medicine, University of Southern California, Los Angeles, California, 
      USA.
AD  - Division of Clinical Immunology and Allergy, Children's Hospital Los Angeles, Los 
      Angeles, California, USA.
LA  - eng
PT  - Journal Article
DEP - 20230119
PL  - United States
TA  - Pediatr Dermatol
JT  - Pediatric dermatology
JID - 8406799
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Humans
MH  - Child
MH  - *Dermatitis, Atopic/diagnosis
MH  - Retrospective Studies
MH  - Immunoglobulin E
MH  - Hospitalization
MH  - *Eczema
OTO - NOTNLM
OT  - S. aureus
OT  - antibiotics
OT  - atopic dermatitis
OT  - biomarkers
OT  - infectious complications
OT  - inpatient
EDAT- 2023/01/20 06:00
MHDA- 2023/03/31 06:42
CRDT- 2023/01/19 04:23
PHST- 2022/07/14 00:00 [received]
PHST- 2022/12/24 00:00 [accepted]
PHST- 2023/03/31 06:42 [medline]
PHST- 2023/01/20 06:00 [pubmed]
PHST- 2023/01/19 04:23 [entrez]
AID - 10.1111/pde.15245 [doi]
PST - ppublish
SO  - Pediatr Dermatol. 2023 Mar;40(2):301-304. doi: 10.1111/pde.15245. Epub 2023 Jan 
      19.