PMID- 36656216
OWN - NLM
STAT- MEDLINE
DCOM- 20230123
LR  - 20230123
IS  - 0974-5130 (Electronic)
IS  - 0377-4929 (Linking)
VI  - 66
IP  - 1
DP  - 2023 Jan-Mar
TI  - Z score analysis: A novel approach to interpretation of an erythrogram.
PG  - 85-90
LID - 10.4103/ijpm.ijpm_1188_21 [doi]
AB  - CONTEXT: Z score defines the shift of an observed value from the mean. AIMS: By 
      determining the direction of this shift and its absolute value for mean 
      corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration 
      (MCHC), one can quickly screen the hemogram for any spurious results in RBC 
      parameters and also predict the type of anemia. This is because MCH and MCHC are 
      derived parameters (from Hb, RBC, MCV) and thereby reflect the true as well as 
      false changes in an erythrogram. MATERIALS AND METHODS: A total of 975 hemograms 
      were studied retrospectively. Basic statistical formulae using mean and standard 
      deviation were applied to calculate z scores for MCH and MCHC. Results obtained 
      were compared with the standard method and validated by an independent cohort of 
      100 random samples run on a different machine. RESULTS AND STATISTICAL ANALYSIS: 
      Z score was found to be statistically significant (p <.001) in diagnosing iron 
      deficiency anemias, megaloblastic anemias, hemolytic anemias, regenerative 
      anemias, anemia of chronic disease and spurious findings. Z score was not 
      significant (p = 0.9) in predicting beta thalassemia trait. The sensitivity was 
      low for the differentials of microcytic hypochromic anemias. CONCLUSIONS: Despite 
      this, Z score can be of immense help to the clinicians and pathologists in making 
      quick interpretation of the underlying red cell abnormalities. Also, it can be 
      used as a quality assessment tool in hematology laboratories taking pre 
      analytical and analytical factors into account.
FAU - Chauhan, Kriti
AU  - Chauhan K
AD  - Department of Pathology, Polo Labs, Mohali, Punjab, India.
FAU - Bisht, Bhumika
AU  - Bisht B
AD  - Department of Pathology, Polo Labs, Ivy Hospital, Mohali, Punjab, India.
FAU - Kathuria, Komal
AU  - Kathuria K
AD  - Department of Pathology, Polo Labs, Mohali, Punjab, India.
FAU - Bisht, Ritu
AU  - Bisht R
AD  - Department of Pathology, Dr. Ahujas' Pathology and Radiology Collection Centre, 
      Dehradun, Uttarakhand, India.
FAU - Hatwal, Varun
AU  - Hatwal V
AD  - Department of Pathology, Polo Labs, Mohali, Punjab, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Pathol Microbiol
JT  - Indian journal of pathology & microbiology
JID - 7605904
SB  - IM
MH  - Humans
MH  - Retrospective Studies
MH  - Erythrocyte Indices
MH  - *Anemia, Hypochromic/diagnosis
MH  - *Anemia, Iron-Deficiency/diagnosis
MH  - *beta-Thalassemia/diagnosis
OTO - NOTNLM
OT  - Anemia
OT  - MCH
OT  - MCHC
OT  - response
OT  - shift
OT  - spurious
COIS- None
EDAT- 2023/01/20 06:00
MHDA- 2023/01/24 06:00
CRDT- 2023/01/19 10:42
PHST- 2023/01/19 10:42 [entrez]
PHST- 2023/01/20 06:00 [pubmed]
PHST- 2023/01/24 06:00 [medline]
AID - IndianJPatholMicrobiol_2023_66_1_85_367940 [pii]
AID - 10.4103/ijpm.ijpm_1188_21 [doi]
PST - ppublish
SO  - Indian J Pathol Microbiol. 2023 Jan-Mar;66(1):85-90. doi: 
      10.4103/ijpm.ijpm_1188_21.