PMID- 36656224
OWN - NLM
STAT- MEDLINE
DCOM- 20230123
LR  - 20230123
IS  - 0974-5130 (Electronic)
IS  - 0377-4929 (Linking)
VI  - 66
IP  - 1
DP  - 2023 Jan-Mar
TI  - A case of TFE3 translocation renal cell carcinoma with rare morphological 
      features and literature review.
PG  - 135-140
LID - 10.4103/ijpm.ijpm_755_21 [doi]
AB  - CONTEXT: TFE3 translocation renal cell carcinoma (RCC) is a rare tumor that 
      represents approximately 1% of RCC. It was classifed as a member of MiT family 
      translocation RCCs by the World Health Organization in 2016. It is characterized 
      by Xp11 translocation gene fusions involving TFE3. The diagnosis of TFE3 
      translocation RCC is based on immunohistochemical analysis and TFE3 break apart 
      probes in FISH analysis, rather than histological characteristics and imaging 
      examination. AIMS: To determine the clinico-pathological, immuno-phenotypic, and 
      cytogenetic characteristics of TFE3 translocation RCC. METHODS AND MATERIALS: The 
      clinical data of a 52-year-old-female patient with TFE3 translocation RCC 
      exhibiting rare morphological characteristics was analyzed, and the tumor tissues 
      were probed using histopathological staining, immunohistochemistry, and 
      fluorescence in situ hybridization (FISH). In addition, the relevant literature 
      was reviewed. RESULTS: This case is a TFE3 translocation RCC with rare 
      morphological features. It composed of two types of tumor cells. TFE3 and pax-8 
      were diffusely and strongly expressed in both tumor cells, and they were 
      partially positive for CAIX, RCC, CK, EMA, CD10, Vim, Melan-A, and p504s. Only 2% 
      of the cells were positive for the proliferation marker Ki-67, and the tumor was 
      negative for CK7, CD117, Inhibin-alpha, HBM45, and p53. FISH showed a positive signal 
      for TFE3 translocation. CONCLUSIONS: This case was a TFE3 translocation RCC with 
      rare morphological features. Through this case report, we emphasize the 
      importance of in situ detection of TFE3 gene translocation and protein in TFE3 
      translocation RCC.
FAU - Xia, Tian
AU  - Xia T
AD  - Department of Pathology, The Affiliated Hospital of Southwest Medical University, 
      Luzhou, China.
FAU - Long, Hanan
AU  - Long H
AD  - Department of Pathology, The Affiliated Hospital of Southwest Medical University, 
      Luzhou, China.
FAU - Liao, Dawei
AU  - Liao D
AD  - Department of Medical Imaging, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, China.
FAU - Wang, Wenyuan
AU  - Wang W
AD  - Department of Medical Ultrasound, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, China.
FAU - Xiao, Xiuli
AU  - Xiao X
AD  - Department of Pathology, The Affiliated Hospital of Southwest Medical University, 
      Luzhou, China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - India
TA  - Indian J Pathol Microbiol
JT  - Indian journal of pathology & microbiology
JID - 7605904
RN  - 0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors)
RN  - 0 (TFE3 protein, human)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Carcinoma, Renal Cell/diagnosis/genetics
MH  - *Kidney Neoplasms/diagnosis/genetics/pathology
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics/metabolism
MH  - Chromosomes, Human, X/genetics/chemistry/metabolism
MH  - Translocation, Genetic
OTO - NOTNLM
OT  - FISH
OT  - TFE3 translocation RCC
OT  - pathological feature
OT  - renal cell carcinoma
COIS- None
EDAT- 2023/01/20 06:00
MHDA- 2023/01/24 06:00
CRDT- 2023/01/19 10:42
PHST- 2023/01/19 10:42 [entrez]
PHST- 2023/01/20 06:00 [pubmed]
PHST- 2023/01/24 06:00 [medline]
AID - IndianJPatholMicrobiol_2023_66_1_135_367981 [pii]
AID - 10.4103/ijpm.ijpm_755_21 [doi]
PST - ppublish
SO  - Indian J Pathol Microbiol. 2023 Jan-Mar;66(1):135-140. doi: 
      10.4103/ijpm.ijpm_755_21.