PMID- 36657154
OWN - NLM
STAT- MEDLINE
DCOM- 20240423
LR  - 20240508
IS  - 1937-1578 (Electronic)
IS  - 1935-1089 (Linking)
VI  - 18
IP  - 3
DP  - 2024 May 1
TI  - DESCRIBING THE LOCATION AND MORPHOLOGY OF THE DOTS IN WHITE DOT FOVEA USING 
      ADAPTIVE OPTICS.
PG  - 275-278
LID - 10.1097/ICB.0000000000001403 [doi]
AB  - PURPOSE: To characterize the white dots in white dot fovea, an entity chiefly 
      described in Japan, using adaptive optics imaging and propose a hypothesis 
      regarding their origin. METHOD: The patient underwent comprehensive ophthalmic 
      examination, including color and green monochromatic fundus photography, 
      fluorescein angiography, spectral-domain optical coherence tomography, and 
      adaptive optics imaging. RESULTS: An asymptomatic 66-year-old Korean woman 
      presented with bilateral white, glistening deposits in a ring pattern around the 
      fovea of both eyes. The dots were highly reflective on green monochromatic 
      images, were not visible on fluorescein angiography, and appeared hyperreflective 
      in the inner retina using spectral-domain optical coherence tomography. Adaptive 
      optics showed polygonal granules ranging from 1 to 10 mu m in size. The patient 
      denied any systemic disorder or the use of any medications related to crystalline 
      retinopathy. The patient had lived in Japan for 35 years before just moving to 
      the United States. CONCLUSION: The location, small size, and polygonal shape of 
      the dots in white dot fovea are suggestive of intraretinal deposition of 
      crystals, and not cells on the surface of the fovea as has been previously 
      proposed. Carotenoid deposition related to dietary habits is a plausible cause 
      because of the similarity to other retinopathies associated to these compounds.
FAU - Salcedo-Ledesma, Alfredo
AU  - Salcedo-Ledesma A
AD  - Vitreous Retina Macula Consultants of New York, New York, New York.
FAU - Ledesma-Gil, Gerardo
AU  - Ledesma-Gil G
FAU - Spaide, Richard F
AU  - Spaide RF
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Retin Cases Brief Rep
JT  - Retinal cases & brief reports
JID - 101298744
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - *Fluorescein Angiography/methods
MH  - *Fovea Centralis/pathology/diagnostic imaging
MH  - Fundus Oculi
MH  - Retinal Diseases/diagnosis/pathology
MH  - *Tomography, Optical Coherence/methods
EDAT- 2023/01/20 06:00
MHDA- 2024/04/23 18:51
CRDT- 2023/01/19 17:13
PHST- 2024/04/23 18:51 [medline]
PHST- 2023/01/20 06:00 [pubmed]
PHST- 2023/01/19 17:13 [entrez]
AID - 01271216-990000000-00139 [pii]
AID - 10.1097/ICB.0000000000001403 [doi]
PST - ppublish
SO  - Retin Cases Brief Rep. 2024 May 1;18(3):275-278. doi: 
      10.1097/ICB.0000000000001403.