PMID- 36657403
OWN - NLM
STAT- MEDLINE
DCOM- 20230601
LR  - 20240303
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Print)
IS  - 1018-2438 (Linking)
VI  - 184
IP  - 5
DP  - 2023
TI  - Using Component-Resolved Diagnosis to Characterize the Sensitization to Specific 
      Cat and Dog Allergens in Patients with Allergic Respiratory Diseases in 
      Catalonia, Spain.
PG  - 440-446
LID - 10.1159/000528643 [doi]
AB  - INTRODUCTION: Sensitization to cat and dog allergens is common in patients with 
      allergic respiratory diseases. The study objective was to determine the 
      prevalence of immunoglobulin E (IgE) sensitization to specific cat and dog 
      allergens using component-resolved diagnosis (CRD) in patients with allergic 
      respiratory diseases plus cat and/or dog sensitization. METHODS: We included 87 
      patients aged 8-62 years, diagnosed with allergic asthma and/or rhinitis plus cat 
      and/or dog sensitization, and attended at the allergy section of a tertiary 
      hospital in Badalona (Catalonia, Spain). We used CRD to determine IgE 
      sensitization to specific cat/dog allergens and skin prick tests (SPTs) to 
      determine differences between diagnostic test results. RESULTS: Patients were 
      monosensitized to cats (20.7%) or dogs (3.4%) or sensitized to both (75.9%). The 
      highest positive allergen rates were for Fel d 1 (91.7%) and Fel d 4 (41%) in 
      patients sensitized to cat allergens and for Can f 5 (80%) and Can f 1 (70%) in 
      those sensitized to dog allergens. CRD and SPT results differed somewhat: 16.1% 
      and 27.6% of patients CRD positive for cat or dog sensitization, respectively, 
      were SPT negative, and 6.9% SPT positive for dog sensitization were CRD negative. 
      Few statistically significant relationships were found between any allergen 
      components and any respiratory disease characteristic or contact with furry 
      animals. CONCLUSIONS: CRD may be used to determine the prevalence of IgE 
      sensitization to specific cat and dog allergens in patients with allergic 
      respiratory diseases plus cat and/or dog sensitization. As SPT may not correctly 
      identify all patients sensitized to cats and dogs, our results support the use of 
      CRD.
CI  - (c) 2023 The Author(s). Published by S. Karger AG, Basel.
FAU - Roger, Albert
AU  - Roger A
AD  - Allergy Section, University Hospital Germans Trias Pujol, Badalona, Spain.
FAU - Lazo, Carlota
AU  - Lazo C
AD  - Allergy Section, University Hospital Germans Trias Pujol, Badalona, Spain.
FAU - Arias, Noelia
AU  - Arias N
AD  - Immunology Department, University Hospital Germans Trias Pujol, Badalona, Spain.
FAU - Quirant, Bibiana
AU  - Quirant B
AD  - Immunology Department, University Hospital Germans Trias Pujol, Badalona, Spain.
FAU - Albert, Nereida
AU  - Albert N
AD  - Allergy Section, University Hospital Germans Trias Pujol, Badalona, Spain.
FAU - Gomez, Mireia
AU  - Gomez M
AD  - Allergy Section, University Hospital Germans Trias Pujol, Badalona, Spain.
FAU - Schayman, Waleska
AU  - Schayman W
AD  - Allergy Section, University Hospital Germans Trias Pujol, Badalona, Spain.
LA  - eng
PT  - Journal Article
DEP - 20230119
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Dogs
MH  - Cats
MH  - Animals
MH  - Allergens
MH  - Spain/epidemiology
MH  - *Hypersensitivity/diagnosis/epidemiology
MH  - *Asthma/diagnosis/epidemiology
MH  - Immunoglobulin E
MH  - Skin Tests
PMC - PMC10906471
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - Asthma
OT  - Cat allergy
OT  - Component-resolved diagnosis
OT  - Dog allergy
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/20 06:00
MHDA- 2023/06/01 06:42
PMCR- 2023/01/19
CRDT- 2023/01/19 18:22
PHST- 2022/09/27 00:00 [received]
PHST- 2022/11/21 00:00 [accepted]
PHST- 2023/06/01 06:42 [medline]
PHST- 2023/01/20 06:00 [pubmed]
PHST- 2023/01/19 18:22 [entrez]
PHST- 2023/01/19 00:00 [pmc-release]
AID - 000528643 [pii]
AID - iaa-0184-0440 [pii]
AID - 10.1159/000528643 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2023;184(5):440-446. doi: 10.1159/000528643. Epub 2023 
      Jan 19.