PMID- 36660008 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231101 IS - 2673-3005 (Print) IS - 2673-298X (Electronic) IS - 2673-298X (Linking) VI - 8 IP - 3-4 DP - 2023 Jan TI - Sex Differences in Health Conditions Associated with Sexual Assault in a Large Hospital Population. PG - 80-89 LID - 10.1159/000527363 [doi] AB - INTRODUCTION: Sexual assault is an urgent public health concern with both immediate and long-lasting health consequences, affecting 44% of women and 25% of men during their lifetimes. Large studies are needed to understand the unique healthcare needs of this patient population. METHODS: We mined clinical notes to identify patients with a history of sexual assault in the electronic health record (EHR) at Vanderbilt University Medical Center (VUMC), a large university hospital in the Southeastern USA, from 1989 to 2021 (N = 3,376,424). Using a phenome-wide case-control study, we identified diagnoses co-occurring with disclosures of sexual assault. We performed interaction tests to examine whether sex modified any of these associations. Association analyses were restricted to a subset of patients receiving regular care at VUMC (N = 833,185). RESULTS: The phenotyping approach identified 14,496 individuals (0.43%) across the VUMC-EHR with documentation of sexual assault and achieved a positive predictive value of 93.0% (95% confidence interval = 85.6-97.0%), determined by manual patient chart review. Out of 1,703 clinical diagnoses tested across all subgroup analyses, 465 were associated with sexual assault. Sex-by-trauma interaction analysis revealed 55 sex-differential associations and demonstrated increased odds of psychiatric diagnoses in male survivors. DISCUSSION: This case-control study identified associations between disclosures of sexual assault and hundreds of health conditions, many of which demonstrated sex-differential effects. The findings of this study suggest that patients who have experienced sexual assault are at risk for developing wide-ranging medical and psychiatric comorbidities and that male survivors may be particularly vulnerable to developing mental illness. CI - The Author(s). Published by S. Karger AG, Basel. FAU - Lake, Allison M AU - Lake AM AD - Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA. AD - Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Goleva, Slavina B AU - Goleva SB AD - National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA. FAU - Samuels, Lauren R AU - Samuels LR AD - Department of Biostatistics, Vanderbilt University, Nashville, Tennessee, USA. FAU - Carpenter, Laura M AU - Carpenter LM AD - Department of Sociology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Davis, Lea K AU - Davis LK AD - Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA. AD - Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. AD - Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA. AD - Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. LA - eng GR - F30 MH132165/MH/NIMH NIH HHS/United States GR - R01 HG011405/HG/NHGRI NIH HHS/United States GR - T32 GM007347/GM/NIGMS NIH HHS/United States PT - Journal Article DEP - 20221007 PL - Switzerland TA - Complex Psychiatry JT - Complex psychiatry JID - 101764441 PMC - PMC10288064 OTO - NOTNLM OT - Clinical informatics OT - Electronic health records OT - Sex differences OT - Women's health COIS- The authors have declared no conflicts of interest. EDAT- 2023/01/21 06:00 MHDA- 2023/01/21 06:01 PMCR- 2023/04/07 CRDT- 2023/01/20 02:05 PHST- 2022/05/31 00:00 [received] PHST- 2022/09/25 00:00 [accepted] PHST- 2023/01/20 02:05 [entrez] PHST- 2023/01/21 06:00 [pubmed] PHST- 2023/01/21 06:01 [medline] PHST- 2023/04/07 00:00 [pmc-release] AID - cxp-0008-0080 [pii] AID - 10.1159/000527363 [doi] PST - ppublish SO - Complex Psychiatry. 2023 Jan;8(3-4):80-89. doi: 10.1159/000527363. Epub 2022 Oct 7.