PMID- 36660894 OWN - NLM STAT- MEDLINE DCOM- 20230404 LR - 20230825 IS - 2190-6009 (Electronic) IS - 2190-5991 (Print) IS - 2190-5991 (Linking) VI - 14 IP - 2 DP - 2023 Apr TI - Plasma inflammation-related biomarkers are associated with intrinsic capacity in community-dwelling older adults. PG - 930-939 LID - 10.1002/jcsm.13163 [doi] AB - BACKGROUND: How inflammation relates to intrinsic capacity (IC), the composite of physical and mental capacities, remains undefined. Our study aimed to investigate the cross-sectional and longitudinal associations between plasma inflammation-related biomarkers and IC in older adults. METHODS: This secondary analysis of the Multidomain Alzheimer Preventive Trial (MAPT) included 1238 community-dwelling older individuals with IC assessments from 12 to 60 months. Plasma C-reactive protein (CRP), interleukin-6 (IL-6), tumour necrosis factor receptor-1 (TNFR-1), monocyte chemoattractant protein-1 (MCP-1) and growth differentiation factor-15 (GDF-15) were measured at 12 months. IC was operationalized as a score ranging from 0 to 100, derived from four domains: cognition, Mini-Mental State Examination; locomotion, Short Physical Performance Battery; psychological, Geriatric Depression Scale; and vitality, handgrip strength. A five-domain IC score (plus sensory) was investigated in a subsample (n = 535) with a 1-year follow-up as an exploratory outcome. RESULTS: The mean age of the 1238 participants was 76.2 years (SD = 4.3); 63.7% were female. Their initial four-domain IC scores averaged 78.9 points (SD = 9.3), with a yearly decline of 1.17 points (95% CI = -1.30 to -1.05; P < 0.001). We observed significant associations of lower baseline IC with higher CRP, IL-6, TNFR-1 and GDF-15, after controlling age, sex, MAPT group allocation and educational level [CRP: adjusted beta (95% CI) = -1.56 (-2.64 to -0.48); P = 0.005; IL-6: adjusted beta = -3.16 (-4.82 to -1.50); P < 0.001; TNFR-1: adjusted beta = -6.86 (-10.25 to -3.47); P < 0.001; GDF-15: adjusted beta = -7.07 (-10.02 to -4.12); P < 0.001]. Higher TNFR-1, MCP-1 and GDF-15 were associated with faster decline in four-domain IC over 4 years [TNFR-1: adjusted beta (95% CI) = -1.28 (-2.29 to -0.27); P = 0.013; MCP-1: adjusted beta = -1.33 (-2.24 to -0.42); P = 0.004; GDF-15: adjusted beta = -1.42 (-2.26 to -0.58); P = 0.001]. None of the biomarkers was significantly associated with the five-domain IC decline. CONCLUSIONS: Inflammation was associated with lower IC in older adults. Among all plasma biomarkers, TNFR-1 and GDF-15 were consistently associated with IC at the cross-sectional and longitudinal levels. CI - (c) 2022 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders. FAU - Lu, Wan-Hsuan AU - Lu WH AUID- ORCID: 0000-0001-7824-4214 AD - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), Toulouse, France. AD - Maintain Aging Research Team, CERPOP, Inserm, Universite Paul Sabatier, Toulouse, France. FAU - Gonzalez-Bautista, Emmanuel AU - Gonzalez-Bautista E AD - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), Toulouse, France. AD - Maintain Aging Research Team, CERPOP, Inserm, Universite Paul Sabatier, Toulouse, France. FAU - Guyonnet, Sophie AU - Guyonnet S AD - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), Toulouse, France. AD - Maintain Aging Research Team, CERPOP, Inserm, Universite Paul Sabatier, Toulouse, France. FAU - Lucas, Alexandre AU - Lucas A AD - Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, Toulouse, France. FAU - Parini, Angelo AU - Parini A AD - Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, Toulouse, France. FAU - Walston, Jeremy D AU - Walston JD AD - Division of Geriatric Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA. FAU - Vellas, Bruno AU - Vellas B AD - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), Toulouse, France. AD - Maintain Aging Research Team, CERPOP, Inserm, Universite Paul Sabatier, Toulouse, France. FAU - de Souto Barreto, Philipe AU - de Souto Barreto P AD - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), Toulouse, France. AD - Maintain Aging Research Team, CERPOP, Inserm, Universite Paul Sabatier, Toulouse, France. CN - MAPT/DSA Group LA - eng GR - P30 AG021334/AG/NIA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20230120 PL - Germany TA - J Cachexia Sarcopenia Muscle JT - Journal of cachexia, sarcopenia and muscle JID - 101552883 RN - 0 (Growth Differentiation Factor 15) RN - 0 (Interleukin-6) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Aged MH - Male MH - *Independent Living MH - Growth Differentiation Factor 15 MH - Hand Strength MH - *Alzheimer Disease MH - Cross-Sectional Studies MH - Interleukin-6 MH - Biomarkers MH - Inflammation PMC - PMC10067471 OTO - NOTNLM OT - Biological ageing OT - Functional decline OT - GDF-15 OT - Geroscience OT - MCP-1 OT - TNFR-1 COIS- The authors have no conflicts of interest. EDAT- 2023/01/21 06:00 MHDA- 2023/04/04 06:42 PMCR- 2023/01/20 CRDT- 2023/01/20 03:43 PHST- 2022/09/27 00:00 [revised] PHST- 2022/04/26 00:00 [received] PHST- 2022/11/25 00:00 [accepted] PHST- 2023/04/04 06:42 [medline] PHST- 2023/01/21 06:00 [pubmed] PHST- 2023/01/20 03:43 [entrez] PHST- 2023/01/20 00:00 [pmc-release] AID - JCSM13163 [pii] AID - 10.1002/jcsm.13163 [doi] PST - ppublish SO - J Cachexia Sarcopenia Muscle. 2023 Apr;14(2):930-939. doi: 10.1002/jcsm.13163. Epub 2023 Jan 20.