PMID- 36662303
OWN - NLM
STAT- MEDLINE
DCOM- 20230124
LR  - 20231221
IS  - 1432-1262 (Electronic)
IS  - 0179-1958 (Linking)
VI  - 38
IP  - 1
DP  - 2023 Jan 20
TI  - Effectiveness of electroacupuncture versus prucalopride for women with severe 
      chronic constipation: secondary analysis of a randomized controlled trial.
PG  - 20
LID - 10.1007/s00384-023-04313-z [doi]
AB  - PURPOSE: Electroacupuncture (EA) is a component alternative therapy for severe 
      chronic constipation (SCC). Women are more vulnerable to SCC and gender might 
      impact the response of patients with functional gastrointestinal disorders to 
      therapy. We performed this secondary analysis to explore the effectiveness and 
      safety of EA compared with prucalopride among women with SCC. METHODS: Based on a 
      multicenter, randomized, noninferiority trial, 446 female patients were randomly 
      assigned to receive 28-session EA (n = 222) over 8 weeks with 24-week follow-up 
      without treatment or to receive prucalopride (n = 224) over 32 consecutive weeks. 
      The primary outcome was the proportion of overall complete spontaneous bowel 
      movements (CSBMs) responders over weeks 1-8, defined as at least three CSBMs per 
      week, and more than an increase of one CSBM from baseline meanwhile for at least 
      6 weeks during an 8-week treatment period. Secondary outcomes measure sustained 
      CSBM responder, weekly responders, change from baseline in mean weekly CSBMs and 
      SBMs, straining and stool consistency, quality of life, and adverse events (AEs). 
      RESULTS: The proportion of overall responders was 25.23% in the EA group, similar 
      to 25.89% in the prucalopride group, with a between-group difference of - 0.67% 
      (95% CI, - 8.80 to 7.40%; P = 0.872) during an 8-week treatment. In the secondary 
      outcomes, EA and prucalopride groups had no significant difference, except that 
      EA was inferior to prucalopride in improving SBMs. The AEs were less in the EA 
      group than the prucalopride group. CONCLUSION: EA may be a promising and safe 
      treatment for women with SCC; its effect could sustain 24 weeks after treatment 
      stopped.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Wang, Xinlu
AU  - Wang X
AD  - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China.
FAU - Sun, Yuanjie
AU  - Sun Y
AD  - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China.
FAU - Yan, Shiyan
AU  - Yan S
AD  - International Acupuncture and Moxibustion Innovation Institute, School of 
      Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Shi, Hangyu
AU  - Shi H
AD  - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China.
AD  - International Acupuncture and Moxibustion Innovation Institute, School of 
      Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Zhu, Lili
AU  - Zhu L
AD  - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China.
FAU - Gao, Shuai
AU  - Gao S
AD  - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China.
FAU - Liu, Zhishun
AU  - Liu Z
AD  - Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China. zhishunjournal@163.com.
LA  - eng
GR  - 2018ZN006/Self-Insured Program by Guang'an men Hospital/
GR  - 2018ZN006/Self-Insured Program by Guang'an men Hospital/
GR  - 2018ZN006/Self-Insured Program by Guang'an men Hospital/
GR  - 2018ZN006/Self-Insured Program by Guang'an men Hospital/
GR  - 2018ZN006/Self-Insured Program by Guang'an men Hospital/
GR  - 2018ZN006/Self-Insured Program by Guang'an men Hospital/
GR  - 2018ZN006/Self-Insured Program by Guang'an men Hospital/
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20230120
PL  - Germany
TA  - Int J Colorectal Dis
JT  - International journal of colorectal disease
JID - 8607899
RN  - 0A09IUW5TP (prucalopride)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Constipation/drug therapy/etiology
MH  - *Electroacupuncture/adverse effects
MH  - Quality of Life
MH  - Defecation
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Acupuncture
OT  - Female
OT  - Functional bowel dysfunction
OT  - Post hoc analysis
EDAT- 2023/01/21 06:00
MHDA- 2023/01/25 06:00
CRDT- 2023/01/20 11:15
PHST- 2023/01/08 00:00 [accepted]
PHST- 2023/01/20 11:15 [entrez]
PHST- 2023/01/21 06:00 [pubmed]
PHST- 2023/01/25 06:00 [medline]
AID - 10.1007/s00384-023-04313-z [pii]
AID - 10.1007/s00384-023-04313-z [doi]
PST - epublish
SO  - Int J Colorectal Dis. 2023 Jan 20;38(1):20. doi: 10.1007/s00384-023-04313-z.