PMID- 36668767
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230201
IS  - 2305-6304 (Electronic)
IS  - 2305-6304 (Linking)
VI  - 11
IP  - 1
DP  - 2022 Dec 31
TI  - Partitioning of Persistent Organic Pollutants between Adipose Tissue and Serum in 
      Human Studies.
LID - 10.3390/toxics11010041 [doi]
LID - 41
AB  - Blood is the most widely used matrix for biomonitoring of persistent organic 
      pollutants (POPs). It is assumed that POPs are homogenously distributed within 
      body lipids at steady state; however, the variability underlying the partitioning 
      of POPs between fat compartments is poorly understood. Hence, the objective of 
      this study was to review the state of the science about the relationships of POPs 
      between adipose tissue and serum in humans. We conducted a narrative literature 
      review of human observational studies reporting concentrations of POPs in paired 
      samples of adipose tissue with other lipid-based compartments (e.g., serum 
      lipids). The searches were conducted in SCOPUS and PUBMED. A meta-regression was 
      performed to identify factors responsible for variability. All included studies 
      reported high variability in the partition coefficients of POPs, mainly between 
      adipose tissue and serum. The number of halogen atoms was the physicochemical 
      variable most strongly and positively associated with the partition ratios, 
      whereas body mass index was the main biological factor positively and 
      significantly associated. To conclude, although this study provides a better 
      understanding of partitioning of POPs to refine physiologically based 
      pharmacokinetic and epidemiological models, further research is still needed to 
      determine other key factors involved in the partitioning of POPs.
FAU - Moriceau, Meg-Anne
AU  - Moriceau MA
AD  - Oniris, INRAE, LABERCA, 44300 Nantes, France.
FAU - Cano-Sancho, German
AU  - Cano-Sancho G
AD  - Oniris, INRAE, LABERCA, 44300 Nantes, France.
FAU - Kim, MinJi
AU  - Kim M
AUID- ORCID: 0000-0002-1403-9331
AD  - INSERM UMR-S 1124, Universite Paris Sorbonne Nord, 93017 Bobigny, France.
FAU - Coumoul, Xavier
AU  - Coumoul X
AUID- ORCID: 0000-0003-2928-9648
AD  - INSERM UMR-S 1124, Universite Paris Cite, 45 rue des Saints-Peres, 75006 Paris, 
      France.
FAU - Emond, Claude
AU  - Emond C
AD  - School of Public Health, Department of Environmental and Occupational Health, 
      University of Montreal, Montreal, QC H3C 3J7, Canada.
FAU - Arrebola, Juan-Pedro
AU  - Arrebola JP
AD  - Department of Preventive Medicine and Public Health, Universidad de Granada, 
      Campus de Cartuja s/n, 18071 Granada, Spain.
AD  - Instituto de Investigacion Biosanitaria (ibs.GRANADA), Avda. de Madrid, 15. 
      Pabellon de Consultas Externas 2, 2a Planta, 18012 Granada, Spain.
AD  - Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 
      Instituto de Salud Carlos III, 28029 Madrid, Spain.
FAU - Antignac, Jean-Philippe
AU  - Antignac JP
AUID- ORCID: 0000-0001-9512-9314
AD  - Oniris, INRAE, LABERCA, 44300 Nantes, France.
FAU - Audouze, Karine
AU  - Audouze K
AD  - INSERM UMR-S 1124, Universite Paris Cite, 45 rue des Saints-Peres, 75006 Paris, 
      France.
FAU - Rousselle, Christophe
AU  - Rousselle C
AUID- ORCID: 0000-0003-0460-6192
AD  - ANSES, European and International Affairs Department, 14 rue Pierre et Marie 
      Curie, 94701 Maisons-Alfort, France.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221231
PL  - Switzerland
TA  - Toxics
JT  - Toxics
JID - 101639637
PMC - PMC9866963
OTO - NOTNLM
OT  - adipose tissue
OT  - biomonitoring
OT  - meta-regression
OT  - partition coefficients
OT  - persistent organic pollutants
COIS- The authors declare they have no actual or potential competing financial 
      interests.
EDAT- 2023/01/21 06:00
MHDA- 2023/01/21 06:01
PMCR- 2022/12/31
CRDT- 2023/01/20 15:30
PHST- 2022/12/01 00:00 [received]
PHST- 2022/12/23 00:00 [revised]
PHST- 2022/12/27 00:00 [accepted]
PHST- 2023/01/20 15:30 [entrez]
PHST- 2023/01/21 06:00 [pubmed]
PHST- 2023/01/21 06:01 [medline]
PHST- 2022/12/31 00:00 [pmc-release]
AID - toxics11010041 [pii]
AID - toxics-11-00041 [pii]
AID - 10.3390/toxics11010041 [doi]
PST - epublish
SO  - Toxics. 2022 Dec 31;11(1):41. doi: 10.3390/toxics11010041.