PMID- 36669681 OWN - NLM STAT- MEDLINE DCOM- 20230515 LR - 20230720 IS - 1878-1780 (Electronic) IS - 1262-3636 (Linking) VI - 49 IP - 3 DP - 2023 May TI - Baseline and longitudinal trajectories of body-mass index and all-cause mortality among patients with type 2 diabetes. PG - 101426 LID - S1262-3636(23)00008-3 [pii] LID - 10.1016/j.diabet.2023.101426 [doi] AB - AIM: To investigate the associations of baseline body mass index (BMI) and longitudinal BMI trajectories with all-cause mortality among patients with type 2 diabetes mellitus (T2DM). METHODS, We used data from the diabetes surveillance system of Yinzhou Health Information System with T2DM patients registered from 2010 to 2015. Participants aged >/= 40 years were included and were followed up until September 30, 2021. The latent class growth mixture model was used to identify different changing patterns in BMI for 5 years from registration. Cox proportional hazards models were used to examine the associations of baseline BMI and 5-year BMI trajectories with all-cause mortality. RESULTS: We observed a nonlinear association between baseline BMI and all-cause mortality (P for nonlinearity < 0.001), with an increased risk of death for low but not high BMI. However, compared with participants with medium-stable BMI for 5 years from baseline, individuals with increasing BMI had higher mortality, with adjusted hazard ratios (95% confidence intervals) 1.21 (1.02;1.43) for early-increasing and 1.47 (1.19;1.80) for late-sharp increasing groups. CONCLUSION: These findings suggest that while obesity itself may not be associated with an increased risk for mortality, weight gain, and in particular rapid weight gain, is a risk factor for mortality among patients with T2DM. CI - Copyright (c) 2023 Elsevier Masson SAS. All rights reserved. FAU - Yang, Zongming AU - Yang Z AD - Department of Public Health, and Department of National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Shen, Peng AU - Shen P AD - Department of Chronic Disease and Health Promotion, Yinzhou District Center for Disease Control and Prevention, Ningbo 315040, China. FAU - Qu, Yanlin AU - Qu Y AD - Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. FAU - Xu, Lisha AU - Xu L AD - Department of Public Health, and Department of National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Li, Tiezheng AU - Li T AD - Department of Public Health, and Department of National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Zhu, Zhanghang AU - Zhu Z AD - Department of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Wu, Yonghao AU - Wu Y AD - Department of Public Health, and Department of National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Yu, Luhua AU - Yu L AD - Department of Public Health, and Department of National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Gao, Kai AU - Gao K AD - Department of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Zhang, Xinhan AU - Zhang X AD - Department of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Yao, Xuecheng AU - Yao X AD - Department of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Meng, Lin AU - Meng L AD - Department of Public Health, Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Lin, Hongbo AU - Lin H AD - Department of Chronic Disease and Health Promotion, Yinzhou District Center for Disease Control and Prevention, Ningbo 315040, China. FAU - Shui, Liming AU - Shui L AD - Yinzhou District Health Bureau of Ningbo, Ningbo 315040, China. FAU - Tang, Mengling AU - Tang M AD - Department of Public Health, Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Jin, Mingjuan AU - Jin M AD - Department of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Chen, Kun AU - Chen K AD - Department of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: ck@zju.edu.cn. FAU - Wang, Jianbing AU - Wang J AD - Department of Public Health, and Department of National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: wangjianbing@zju.edu.cn. LA - eng PT - Journal Article DEP - 20230117 PL - France TA - Diabetes Metab JT - Diabetes & metabolism JID - 9607599 SB - IM MH - Humans MH - Body Mass Index MH - *Diabetes Mellitus, Type 2/complications MH - Obesity/complications/epidemiology MH - Risk Factors MH - Weight Gain OTO - NOTNLM OT - BMI OT - Mortality OT - Trajectory analysis OT - Type 2 diabetes EDAT- 2023/01/21 06:00 MHDA- 2023/05/15 06:42 CRDT- 2023/01/20 19:25 PHST- 2022/08/31 00:00 [received] PHST- 2023/01/03 00:00 [revised] PHST- 2023/01/05 00:00 [accepted] PHST- 2023/05/15 06:42 [medline] PHST- 2023/01/21 06:00 [pubmed] PHST- 2023/01/20 19:25 [entrez] AID - S1262-3636(23)00008-3 [pii] AID - 10.1016/j.diabet.2023.101426 [doi] PST - ppublish SO - Diabetes Metab. 2023 May;49(3):101426. doi: 10.1016/j.diabet.2023.101426. Epub 2023 Jan 17.