PMID- 36672342
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230123
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 15
IP  - 2
DP  - 2023 Jan 6
TI  - Roles of IL-7R Induced by Interactions between Cancer Cells and Macrophages in 
      the Progression of Esophageal Squamous Cell Carcinoma.
LID - 10.3390/cancers15020394 [doi]
LID - 394
AB  - High infiltration of tumor-associated macrophages (TAMs), which contribute to the 
      progression of several cancer types, is correlated with poor prognosis of 
      esophageal squamous cell carcinoma (ESCC). In addition to the previously reported 
      increase in migration and invasion, ESCC cells co-cultured directly with 
      macrophages exhibited enhanced survival and growth. Furthermore, 
      interleukin-related molecules are associated with ESCC; however, the precise 
      mechanism underlying this association is unclear. Therefore, we explored the role 
      of interleukin-related molecules in ESCC progression. A cDNA microarray analysis 
      of monocultured and co-cultured ESCC cells revealed that the interleukin 7 
      receptor (IL-7R) was upregulated in ESCC cells co-cultured with macrophages. 
      Overexpression of IL-7R promoted the survival and growth of ESCC cells by 
      activating the Akt and Erk1/2 signaling pathways. The IL-7/IL-7R axis also 
      contributed to the promotion of ESCC cell migration via the Akt and Erk1/2 
      signaling pathways. Furthermore, immunohistochemistry showed that ESCC patients 
      with high IL-7R expression in cancer nests exhibited a trend toward poor 
      prognosis in terms of disease-free survival, and showed significant correlation 
      with increased numbers of infiltrating macrophages and cancer-associated 
      fibroblasts. Therefore, IL-7R, which is upregulated when directly co-cultured 
      with macrophages, may contribute to ESCC progression by promoting the development 
      of various malignant phenotypes in cancer cells.
FAU - Kitamura, Yu
AU  - Kitamura Y
AD  - Division of Pathology, Department of Pathology, Kobe University Graduate School 
      of Medicine, Kobe 650-0017, Japan.
AD  - Division of Gastro-Intestinal Surgery, Department of Surgery, Kobe University 
      Graduate School of Medicine, Kobe 650-0017, Japan.
FAU - Koma, Yu-Ichiro
AU  - Koma YI
AUID- ORCID: 0000-0002-3022-8466
AD  - Division of Pathology, Department of Pathology, Kobe University Graduate School 
      of Medicine, Kobe 650-0017, Japan.
FAU - Tanigawa, Kohei
AU  - Tanigawa K
AD  - Division of Pathology, Department of Pathology, Kobe University Graduate School 
      of Medicine, Kobe 650-0017, Japan.
AD  - Division of Gastro-Intestinal Surgery, Department of Surgery, Kobe University 
      Graduate School of Medicine, Kobe 650-0017, Japan.
FAU - Tsukamoto, Shuichi
AU  - Tsukamoto S
AD  - Division of Pathology, Department of Pathology, Kobe University Graduate School 
      of Medicine, Kobe 650-0017, Japan.
FAU - Azumi, Yuki
AU  - Azumi Y
AD  - Division of Pathology, Department of Pathology, Kobe University Graduate School 
      of Medicine, Kobe 650-0017, Japan.
AD  - Division of Gastro-Intestinal Surgery, Department of Surgery, Kobe University 
      Graduate School of Medicine, Kobe 650-0017, Japan.
FAU - Miyako, Shoji
AU  - Miyako S
AUID- ORCID: 0000-0002-1081-0379
AD  - Division of Pathology, Department of Pathology, Kobe University Graduate School 
      of Medicine, Kobe 650-0017, Japan.
AD  - Division of Gastro-Intestinal Surgery, Department of Surgery, Kobe University 
      Graduate School of Medicine, Kobe 650-0017, Japan.
FAU - Urakami, Satoshi
AU  - Urakami S
AD  - Division of Pathology, Department of Pathology, Kobe University Graduate School 
      of Medicine, Kobe 650-0017, Japan.
AD  - Division of Gastroenterology, Department of Internal Medicine, Kobe University 
      Graduate School of Medicine, Kobe 650-0017, Japan.
FAU - Kodama, Takayuki
AU  - Kodama T
AUID- ORCID: 0000-0002-6518-5574
AD  - Division of Pathology, Department of Pathology, Kobe University Graduate School 
      of Medicine, Kobe 650-0017, Japan.
FAU - Nishio, Mari
AU  - Nishio M
AUID- ORCID: 0000-0002-7413-0751
AD  - Division of Pathology, Department of Pathology, Kobe University Graduate School 
      of Medicine, Kobe 650-0017, Japan.
FAU - Shigeoka, Manabu
AU  - Shigeoka M
AD  - Division of Pathology, Department of Pathology, Kobe University Graduate School 
      of Medicine, Kobe 650-0017, Japan.
FAU - Kakeji, Yoshihiro
AU  - Kakeji Y
AUID- ORCID: 0000-0002-2727-0241
AD  - Division of Gastro-Intestinal Surgery, Department of Surgery, Kobe University 
      Graduate School of Medicine, Kobe 650-0017, Japan.
FAU - Yokozaki, Hiroshi
AU  - Yokozaki H
AUID- ORCID: 0000-0001-5276-3331
AD  - Division of Pathology, Department of Pathology, Kobe University Graduate School 
      of Medicine, Kobe 650-0017, Japan.
LA  - eng
GR  - 20K07373/Japan Society for the Promotion of Science/
GR  - 22K06978/Japan Society for the Promotion of Science/
GR  - no grant number/Takeda Science Foundation/
PT  - Journal Article
DEP - 20230106
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC9856499
OTO - NOTNLM
OT  - IL-7R
OT  - direct co-culture
OT  - esophageal cancer
OT  - immunohistochemistry
OT  - prognostic factor
OT  - tumor-associated macrophages
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/22 06:00
MHDA- 2023/01/22 06:01
PMCR- 2023/01/06
CRDT- 2023/01/21 01:12
PHST- 2022/12/26 00:00 [received]
PHST- 2022/12/30 00:00 [revised]
PHST- 2023/01/03 00:00 [accepted]
PHST- 2023/01/21 01:12 [entrez]
PHST- 2023/01/22 06:00 [pubmed]
PHST- 2023/01/22 06:01 [medline]
PHST- 2023/01/06 00:00 [pmc-release]
AID - cancers15020394 [pii]
AID - cancers-15-00394 [pii]
AID - 10.3390/cancers15020394 [doi]
PST - epublish
SO  - Cancers (Basel). 2023 Jan 6;15(2):394. doi: 10.3390/cancers15020394.