PMID- 36674567
OWN - NLM
STAT- MEDLINE
DCOM- 20230124
LR  - 20230124
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 2
DP  - 2023 Jan 5
TI  - The Advancement of Biodegradable Polyesters as Delivery Systems for Camptothecin 
      and Its Analogues-A Status Report.
LID - 10.3390/ijms24021053 [doi]
LID - 1053
AB  - Camptothecin (CPT) has demonstrated antitumor activity in lung, ovarian, breast, 
      pancreas, and stomach cancers. However, this drug, like many other potent 
      anticancer agents, is extremely water-insoluble. Furthermore, pharmacology 
      studies have revealed that prolonged schedules must be administered continuously. 
      For these reasons, several of its water-soluble analogues, prodrugs, and 
      macromolecular conjugates have been synthesized, and various formulation 
      approaches have been investigated. Biodegradable polyesters have gained 
      popularity in cancer treatment in recent years. A number of biodegradable 
      polymeric drug delivery systems (DDSs), designed for localized and systemic 
      administration of therapeutic agents, as well as tumor-targeting macromolecules, 
      have entered clinical trials, demonstrating the importance of biodegradable 
      polyesters in cancer therapy. Biodegradable polyester-based DDSs have the 
      potential to deliver the payload to the target while also increasing drug 
      availability at intended site. The systemic toxicity and serious side-effects 
      associated with conventional cancer therapies can be significantly reduced with 
      targeted polymeric systems. This review elaborates on the use of biodegradable 
      polyesters in the delivery of CPT and its analogues. The design of various DDSs 
      based on biodegradable polyesters has been described, with the drug either 
      adsorbed on the polymer's surface or encapsulated within its macrostructure, as 
      well as those in which a hydrolyzed chemical bond is formed between the active 
      substance and the polymer chain. The data related to the type of DDSs, the kind 
      of linkage, and the details of in vitro and in vivo studies are included.
FAU - Strzelecka, Katarzyna
AU  - Strzelecka K
AD  - Department of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical 
      University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.
FAU - Piotrowska, Urszula
AU  - Piotrowska U
AUID- ORCID: 0000-0002-2418-9528
AD  - Department of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical 
      University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.
FAU - Sobczak, Marcin
AU  - Sobczak M
AUID- ORCID: 0000-0002-7362-8881
AD  - Department of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical 
      University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.
AD  - Military Institute of Hygiene and Epidemiology, 4 Kozielska Str., 01-163 Warsaw, 
      Poland.
FAU - Oledzka, Ewa
AU  - Oledzka E
AUID- ORCID: 0000-0003-0660-3315
AD  - Department of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical 
      University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230105
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Polyesters)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Polymers)
RN  - XT3Z54Z28A (Camptothecin)
SB  - IM
MH  - *Polyesters/chemistry
MH  - Drug Delivery Systems
MH  - *Antineoplastic Agents/pharmacology/therapeutic use
MH  - Polymers/chemistry
MH  - Camptothecin
PMC - PMC9866533
OTO - NOTNLM
OT  - biodegradable carriers
OT  - biodegradable polyesters
OT  - bioresorbable polyesters
OT  - camptothecin
OT  - drug delivery systems
OT  - synthetic derivatives of camptothecin
OT  - targeted therapy
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/22 06:00
MHDA- 2023/01/25 06:00
PMCR- 2023/01/05
CRDT- 2023/01/21 01:25
PHST- 2022/12/09 00:00 [received]
PHST- 2022/12/29 00:00 [revised]
PHST- 2023/01/03 00:00 [accepted]
PHST- 2023/01/21 01:25 [entrez]
PHST- 2023/01/22 06:00 [pubmed]
PHST- 2023/01/25 06:00 [medline]
PHST- 2023/01/05 00:00 [pmc-release]
AID - ijms24021053 [pii]
AID - ijms-24-01053 [pii]
AID - 10.3390/ijms24021053 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Jan 5;24(2):1053. doi: 10.3390/ijms24021053.