PMID- 36674906
OWN - NLM
STAT- MEDLINE
DCOM- 20230124
LR  - 20230201
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 2
DP  - 2023 Jan 10
TI  - Shape-Memory-Reduced Graphene/Chitosan Cryogels for Non-Compressible Wounds.
LID - 10.3390/ijms24021389 [doi]
LID - 1389
AB  - In this study, an antibacterial and shape-memory chitosan cryogel with high blood 
      absorption and fast recovery from non-compressible wounds was prepared using a 
      one-step method. Herein, we prepared a shape-memory-reduced graphene/chitosan 
      (rGO-CTS) cryogel using a one-step method with a frozen mixing solution of 
      chitosan, citric acid, dopamine, and graphene oxide, before treating it with 
      alkaline solutions. The alkaline solution not only promoted the double 
      cross-linking of chitosan but also induced dopamine to form polydopamine-reducing 
      graphene oxide. Scanning electron microscope (SEM) images showed that the rGO-CTS 
      cryogel possessed a uniform porous network structure, attributing excellent 
      water-induced shape-memory properties. Moreover, the rGO-CTS cryogel exhibited 
      good mechanical properties, antibacterial activity, and biocompatibility. In 
      mouse liver trauma models, the rGO-CTS cryogel showed good blood clotting and 
      hemostatic capabilities. Therefore, this composite cryogel has great potential as 
      a new hemostatic material for application to non-compressible wounds.
FAU - Xuan, Hongyun
AU  - Xuan H
AD  - School of Life Science, Nantong University, Nantong 226019, China.
FAU - Du, Qian
AU  - Du Q
AD  - School of Life Science, Nantong University, Nantong 226019, China.
FAU - Li, Ruimeng
AU  - Li R
AD  - School of Life Science, Nantong University, Nantong 226019, China.
FAU - Shen, Xiaoni
AU  - Shen X
AD  - School of Life Science, Nantong University, Nantong 226019, China.
FAU - Zhou, Jiao
AU  - Zhou J
AD  - School of Life Science, Nantong University, Nantong 226019, China.
FAU - Li, Biyun
AU  - Li B
AD  - School of Life Science, Nantong University, Nantong 226019, China.
FAU - Jin, Yan
AU  - Jin Y
AUID- ORCID: 0000-0003-4664-4787
AD  - School of Life Science, Nantong University, Nantong 226019, China.
FAU - Yuan, Huihua
AU  - Yuan H
AUID- ORCID: 0000-0001-8657-984X
AD  - School of Life Science, Nantong University, Nantong 226019, China.
LA  - eng
GR  - 32000965 and 81801856/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20230110
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 9012-76-4 (Chitosan)
RN  - 0 (graphene oxide)
RN  - 7782-42-5 (Graphite)
RN  - 0 (Cryogels)
RN  - VTD58H1Z2X (Dopamine)
RN  - 0 (Hemostatics)
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Chitosan/chemistry
MH  - *Graphite/pharmacology/chemistry
MH  - Cryogels/chemistry
MH  - Dopamine
MH  - *Hemostatics
MH  - Disease Models, Animal
MH  - Anti-Bacterial Agents/pharmacology
PMC - PMC9863902
OTO - NOTNLM
OT  - antibacterial
OT  - hemostatic
OT  - one-step method
OT  - reduced graphene/chitosan cryogel
OT  - shape memory
COIS- The authors declare no conflicts of interest.
EDAT- 2023/01/22 06:00
MHDA- 2023/01/25 06:00
PMCR- 2023/01/10
CRDT- 2023/01/21 01:27
PHST- 2022/12/07 00:00 [received]
PHST- 2023/01/06 00:00 [revised]
PHST- 2023/01/10 00:00 [accepted]
PHST- 2023/01/21 01:27 [entrez]
PHST- 2023/01/22 06:00 [pubmed]
PHST- 2023/01/25 06:00 [medline]
PHST- 2023/01/10 00:00 [pmc-release]
AID - ijms24021389 [pii]
AID - ijms-24-01389 [pii]
AID - 10.3390/ijms24021389 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Jan 10;24(2):1389. doi: 10.3390/ijms24021389.