PMID- 36675009
OWN - NLM
STAT- MEDLINE
DCOM- 20230124
LR  - 20230202
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 2
DP  - 2023 Jan 12
TI  - Dietary Habits and Nutrient Deficiencies in a Cohort of European Crohn's Disease 
      Adult Patients.
LID - 10.3390/ijms24021494 [doi]
LID - 1494
AB  - Wrong dietary habits, such as the Western-style diet, are considered important 
      risk factors for the development of Inflammatory Bowel Diseases (IBDs). 
      Nevertheless, the role of dietary patterns in the clinical management of IBD 
      patients has not been fully investigated yet. Fifty-four patients diagnosed with 
      active Crohn's disease (CD) were enrolled and subjected to nutritional intake 
      analysis through a weekly food diary. Nutritional patterns were analyzed, and 
      nutrient intake was compared with those of 30 healthy subjects (HS). Blood levels 
      of cholesterol, folic acid, minerals (K, Mg, Fe) and amino acids, were measured 
      in CD patients to assess the presence of nutritional deficiencies. CD patients, 
      with respect to HS, consumed significantly lower amounts of fiber, vitamins (A, 
      E, C, B6, folic acid) and beta-carotene. Their calcium, potassium, phosphorus, iron, 
      magnesium, copper and iodine intake were also found to be significantly lower. In 
      blood, CD patients had significantly lower concentrations of total cholesterol, 
      potassium, iron, and amino acids. Active CD patient diet was significantly 
      different from those of HS and may contribute to the establishment of nutritional 
      deficiencies. Intestinal malabsorption was evidenced in these patients. 
      Correction of the diet with specific nutritional plans is a necessary therapeutic 
      step for these patients. ClinicalTrials.gov: NCT02580864.
FAU - Rizzello, Fernando
AU  - Rizzello F
AD  - IBD Unit, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, University of 
      Bologna, Via Massarenti 9, 40138 Bologna, Italy.
FAU - Gionchetti, Paolo
AU  - Gionchetti P
AD  - IBD Unit, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, University of 
      Bologna, Via Massarenti 9, 40138 Bologna, Italy.
FAU - Spisni, Enzo
AU  - Spisni E
AUID- ORCID: 0000-0002-8525-2981
AD  - Department of Biological, Geological and Environmental Sciences, University of 
      Bologna, Via Selmi 3, 40126 Bologna, Italy.
FAU - Saracino, Ilaria Maria
AU  - Saracino IM
AUID- ORCID: 0000-0003-4388-7089
AD  - Microbiology Unit, Department of Specialized, Experimental and Diagnostic 
      Medicine, St. Orsola Hospital, University of Bologna, Via Massarenti 9, 40138 
      Bologna, Italy.
FAU - Bellocchio, Irene
AU  - Bellocchio I
AD  - Department of Biological, Geological and Environmental Sciences, University of 
      Bologna, Via Selmi 3, 40126 Bologna, Italy.
FAU - Spigarelli, Renato
AU  - Spigarelli R
AUID- ORCID: 0000-0002-1870-7536
AD  - Department of Biological, Geological and Environmental Sciences, University of 
      Bologna, Via Selmi 3, 40126 Bologna, Italy.
FAU - Collini, Noemi
AU  - Collini N
AD  - Department of Biological, Geological and Environmental Sciences, University of 
      Bologna, Via Selmi 3, 40126 Bologna, Italy.
FAU - Imbesi, Veronica
AU  - Imbesi V
AD  - IBD Unit, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, University of 
      Bologna, Via Massarenti 9, 40138 Bologna, Italy.
FAU - Dervieux, Thierry
AU  - Dervieux T
AD  - Prometheus Laboratories, 9410 Carroll Park Dr., San Diego, CA 92121, USA.
FAU - Alvisi, Patrizia
AU  - Alvisi P
AD  - Pediatric Gastroenterology Unit, Maggiore Hospital, Largo Nigrisoli, 2, 40133 
      Bologna, Italy.
FAU - Valerii, Maria Chiara
AU  - Valerii MC
AD  - Department of Biological, Geological and Environmental Sciences, University of 
      Bologna, Via Selmi 3, 40126 Bologna, Italy.
LA  - eng
SI  - ClinicalTrials.gov/NCT02580864
GR  - NIHS: RDHS000343/Nestle Institute of Health Sciences, Batiments G & H, EPFL 
      In-novation Park, 1015 Lausanne, Swiss/
PT  - Journal Article
DEP - 20230112
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Vitamins)
RN  - 935E97BOY8 (Folic Acid)
RN  - E1UOL152H7 (Iron)
RN  - RWP5GA015D (Potassium)
RN  - 0 (Amino Acids)
SB  - IM
MH  - Humans
MH  - Adult
MH  - *Crohn Disease/complications
MH  - Diet/adverse effects
MH  - Nutritional Status
MH  - Feeding Behavior
MH  - Vitamins
MH  - *Malnutrition/etiology
MH  - Folic Acid
MH  - Iron
MH  - Potassium
MH  - Amino Acids
PMC - PMC9865585
OTO - NOTNLM
OT  - Crohn's disease
OT  - intestinal malabsorption
OT  - mineral
OT  - nutrient deficiency
OT  - vitamins
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/22 06:00
MHDA- 2023/01/25 06:00
PMCR- 2023/01/12
CRDT- 2023/01/21 01:27
PHST- 2022/11/30 00:00 [received]
PHST- 2023/01/09 00:00 [revised]
PHST- 2023/01/10 00:00 [accepted]
PHST- 2023/01/21 01:27 [entrez]
PHST- 2023/01/22 06:00 [pubmed]
PHST- 2023/01/25 06:00 [medline]
PHST- 2023/01/12 00:00 [pmc-release]
AID - ijms24021494 [pii]
AID - ijms-24-01494 [pii]
AID - 10.3390/ijms24021494 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Jan 12;24(2):1494. doi: 10.3390/ijms24021494.