PMID- 36675837
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230918
IS  - 2309-608X (Electronic)
IS  - 2309-608X (Linking)
VI  - 9
IP  - 1
DP  - 2022 Dec 22
TI  - Meningeal Sporotrichosis Due to Sporothrix brasiliensis: A 21-Year Cohort Study 
      from a Brazilian Reference Center.
LID - 10.3390/jof9010017 [doi]
LID - 17
AB  - Meningeal sporotrichosis is rare and occurs predominantly in immunosuppressed 
      individuals. This retrospective study explored clinical and laboratory 
      characteristics, treatment, and prognosis of patients with disseminated 
      sporotrichosis who underwent lumbar puncture (LP) at a Brazilian reference center 
      from 1999 to 2020. Kaplan-Meier and Cox regression models were used to estimate 
      overall survival and hazard ratios. Among 57 enrolled patients, 17 had 
      meningitis. Fifteen (88.2%) had HIV infection, and in 6 of them, neurological 
      manifestations occurred because of the immune reconstitution inflammatory 
      syndrome (IRIS). The most frequent symptom was headache (88.2%). Meningeal 
      symptoms at first LP were absent in 7/17 (41.2%) patients. Sporothrix was 
      diagnosed in cerebrospinal fluid either by culture or by polymerase chain 
      reaction in seven and four patients, respectively. All but one patient received 
      prolonged courses of amphotericin B formulations, and seven received 
      posaconazole, but relapses were frequent. Lethality among patients with 
      meningitis was 64.7%, with a higher chance of death compared to those without 
      meningitis (HR = 3.87; IC95% = 1.23;12.17). Meningeal sporotrichosis occurs 
      mostly in people with HIV and can be associated with IRIS. Screening LP is 
      indicated in patients with disseminated disease despite the absence of 
      neurological complaints. Meningitis is associated with poor prognosis, and better 
      treatment strategies are needed.
FAU - Lima, Marco A
AU  - Lima MA
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
AD  - Neurology Section, Hospital Universitario Clementino Fraga Filho, The Federal 
      University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-617, Brazil.
FAU - Freitas, Dayvison F S
AU  - Freitas DFS
AUID- ORCID: 0000-0003-2039-2438
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
FAU - Oliveira, Raquel V C
AU  - Oliveira RVC
AUID- ORCID: 0000-0001-9387-8645
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
FAU - Fichman, Vivian
AU  - Fichman V
AUID- ORCID: 0000-0003-0348-8008
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
FAU - Varon, Andrea G
AU  - Varon AG
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
FAU - Freitas, Andrea D
AU  - Freitas AD
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
FAU - Lamas, Cristiane C
AU  - Lamas CC
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
FAU - Andrade, Hugo B
AU  - Andrade HB
AUID- ORCID: 0000-0001-6781-6125
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
FAU - Veloso, Valdilea G
AU  - Veloso VG
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
FAU - Almeida-Paes, Rodrigo
AU  - Almeida-Paes R
AUID- ORCID: 0000-0002-6639-6058
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
FAU - Almeida-Silva, Fernando
AU  - Almeida-Silva F
AUID- ORCID: 0000-0002-7378-1990
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
FAU - Zancope-Oliveira, Rosely Maria
AU  - Zancope-Oliveira RM
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
FAU - de Macedo, Priscila M
AU  - de Macedo PM
AUID- ORCID: 0000-0002-6900-9703
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
FAU - Valle, Antonio C F
AU  - Valle ACF
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
FAU - Silva, Marcus T T
AU  - Silva MTT
AUID- ORCID: 0000-0003-4479-4132
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
FAU - Araujo, Abelardo Q C
AU  - Araujo AQC
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
AD  - Deolindo Couto Institute of Neurology (INDC), The Federal University of Rio de 
      Janeiro (UFRJ), Rio de Janeiro 22290-140, Brazil.
FAU - Gutierrez-Galhardo, Maria C
AU  - Gutierrez-Galhardo MC
AD  - Evandro Chagas National Institute of Infectious Diseases (INI), FIOCRUZ, 
      Brazilian Ministry of Health, Rio de Janeiro 21040-900, Brazil.
LA  - eng
GR  - E-26/202.527/2019]/Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do 
      Rio de Janeiro/
GR  - 308315/2021-9/National Council for Scientific and Technological Development/
GR  - INI-003-FIO-19-2-13/Oswaldo Cruz Foundation/
PT  - Journal Article
DEP - 20221222
PL  - Switzerland
TA  - J Fungi (Basel)
JT  - Journal of fungi (Basel, Switzerland)
JID - 101671827
PMC - PMC9863964
OTO - NOTNLM
OT  - HIV
OT  - Sporothrix brasiliensis
OT  - immune reconstitution inflammatory syndrome
OT  - meningitis
OT  - sporotrichosis
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/22 06:00
MHDA- 2023/01/22 06:01
PMCR- 2022/12/22
CRDT- 2023/01/21 01:32
PHST- 2022/11/14 00:00 [received]
PHST- 2022/12/19 00:00 [revised]
PHST- 2022/12/20 00:00 [accepted]
PHST- 2023/01/21 01:32 [entrez]
PHST- 2023/01/22 06:00 [pubmed]
PHST- 2023/01/22 06:01 [medline]
PHST- 2022/12/22 00:00 [pmc-release]
AID - jof9010017 [pii]
AID - jof-09-00017 [pii]
AID - 10.3390/jof9010017 [doi]
PST - epublish
SO  - J Fungi (Basel). 2022 Dec 22;9(1):17. doi: 10.3390/jof9010017.