PMID- 36676067
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230704
IS  - 2075-1729 (Print)
IS  - 2075-1729 (Electronic)
IS  - 2075-1729 (Linking)
VI  - 13
IP  - 1
DP  - 2022 Dec 31
TI  - Upregulation of Neuroinflammatory Protein Biomarkers in Acute Rhegmatogenous 
      Retinal Detachments.
LID - 10.3390/life13010118 [doi]
LID - 118
AB  - The purpose of this study is to characterize the inflammatory cytokine profile in 
      rhegmatogenous retinal detachments (RRDs) compared to surgical controls. Vitreous 
      humor was collected from patients undergoing vitrectomy for RRD and 
      noninflammatory vitreoretinal diseases. A quantitative immunoassay was used to 
      measure the levels of 36 cytokine markers. Linear regression analysis with the 
      duration of detachment as the predictor and log-transformed cytokine levels as 
      the outcome was conducted for normally distributed cytokines as determined by the 
      Shapiro-Wilk test. The analysis was adjusted for age, sex, and race. The 
      Kruskal-Wallis test was used for cytokines not normally distributed. Twenty-seven 
      RRD cases and thirteen control cases were studied. Between all RRDs and controls, 
      fibroblast growth factor 2 (FGF2) (p = 0.0029), inducible protein-10(IP-10) (p = 
      0.0021), monocyte chemoattractant protein-1 (MCP-1) (p = 0.0040), interleukin 
      (IL)-16 (p = 0.018), IL-8 (p = 0.0148), IL-6 (p = 0.0071), eotaxin (p = 0.0323), 
      macrophage inflammatory protein (MIP)-1 alpha (p = 0.0149), MIP-1 beta (p = 
      0.0032), and the thymus and activation regulated cytokine (TARC) (p = 0.0121) 
      were elevated in RRD cases. Between acute RRDs (n = 16) and controls, FGF2 (p = 
      0.0001), IP10 (p = 0.0027), MCP-1 (p = 0.0015), MIP-1beta (p = 0.0004), IL-8 (p = 
      0.0146), and IL-6 (p = 0.0031) were elevated. Determining alterations in 
      inflammatory cytokine profiles may aid in understanding their impact on RRD 
      development, clinical course, and complications before and after surgical repair.
FAU - Prasad, Minali
AU  - Prasad M
AUID- ORCID: 0000-0003-0596-1903
AD  - Department of Ophthalmology, Boston University School of Medicine & Boston 
      Medical Center, Boston, MA 02118, USA.
FAU - Xu, Jia
AU  - Xu J
AUID- ORCID: 0000-0002-0019-9502
AD  - Department of Ophthalmology, Boston University School of Medicine & Boston 
      Medical Center, Boston, MA 02118, USA.
FAU - Agranat, Joshua S
AU  - Agranat JS
AUID- ORCID: 0000-0001-5310-0353
AD  - Department of Ophthalmology, Boston University School of Medicine & Boston 
      Medical Center, Boston, MA 02118, USA.
FAU - Xia, Weiming
AU  - Xia W
AD  - Department of Pharmacology and Experimental Therapeutics, Boston University 
      School of Medicine, 72 East Concord Street, Boston, MA 02118, USA.
AD  - Geriatric Research Education and Clinical Center, VA Bedford Healthcare System, 
      Bedford, MA 01730, USA.
FAU - Daley, Sarah
AU  - Daley S
AD  - Department of Pharmacology and Experimental Therapeutics, Boston University 
      School of Medicine, 72 East Concord Street, Boston, MA 02118, USA.
AD  - Geriatric Research Education and Clinical Center, VA Bedford Healthcare System, 
      Bedford, MA 01730, USA.
FAU - Ness, Steven
AU  - Ness S
AD  - Department of Ophthalmology, Boston University School of Medicine & Boston 
      Medical Center, Boston, MA 02118, USA.
FAU - Chen, Xuejing
AU  - Chen X
AUID- ORCID: 0000-0001-6827-0152
AD  - Department of Ophthalmology, Boston University School of Medicine & Boston 
      Medical Center, Boston, MA 02118, USA.
FAU - Siegel, Nicole H
AU  - Siegel NH
AUID- ORCID: 0000-0002-3523-8225
AD  - Department of Ophthalmology, Boston University School of Medicine & Boston 
      Medical Center, Boston, MA 02118, USA.
FAU - Stein, Thor D
AU  - Stein TD
AD  - Laboratory Medicine, Department of Pathology, Boston University School of 
      Medicine, Boston, MA 02118, USA.
AD  - VA Bedford Healthcare System, Bedford, MA 01730, USA.
AD  - VA Boston Healthcare System, Boston, MA 02130, USA.
FAU - Chung, Jaeyoon
AU  - Chung J
AUID- ORCID: 0000-0002-6431-9454
AD  - Department of Medicine (Biomedical Genetics), Boston University School of 
      Medicine, 72 East Concord Street, Boston, MA 02118, USA.
FAU - Subramanian, Manju L
AU  - Subramanian ML
AD  - Department of Ophthalmology, Boston University School of Medicine & Boston 
      Medical Center, Boston, MA 02118, USA.
LA  - eng
GR  - R03 AG063255/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20221231
PL  - Switzerland
TA  - Life (Basel)
JT  - Life (Basel, Switzerland)
JID - 101580444
PMC - PMC9862737
OTO - NOTNLM
OT  - fibroblast growth factor
OT  - inducible protein-10
OT  - interleukin 6
OT  - interleukin 8
OT  - macrophage inflammatory protein-1 beta
OT  - monocyte chemoattractant protein-1
OT  - neuroinflammatory markers
OT  - rhegmatogenous retinal detachment
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2023/01/22 06:00
MHDA- 2023/01/22 06:01
PMCR- 2022/12/31
CRDT- 2023/01/21 01:34
PHST- 2022/11/07 00:00 [received]
PHST- 2022/12/20 00:00 [revised]
PHST- 2022/12/26 00:00 [accepted]
PHST- 2023/01/21 01:34 [entrez]
PHST- 2023/01/22 06:00 [pubmed]
PHST- 2023/01/22 06:01 [medline]
PHST- 2022/12/31 00:00 [pmc-release]
AID - life13010118 [pii]
AID - life-13-00118 [pii]
AID - 10.3390/life13010118 [doi]
PST - epublish
SO  - Life (Basel). 2022 Dec 31;13(1):118. doi: 10.3390/life13010118.