PMID- 36676849
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230201
IS  - 2077-0375 (Print)
IS  - 2077-0375 (Electronic)
IS  - 2077-0375 (Linking)
VI  - 13
IP  - 1
DP  - 2022 Dec 29
TI  - The Role of Inorganic Phosphate Transporters in Highly Proliferative Cells: From 
      Protozoan Parasites to Cancer Cells.
LID - 10.3390/membranes13010042 [doi]
LID - 42
AB  - In addition to their standard inorganic phosphate (Pi) nutritional function, Pi 
      transporters have additional roles in several cells, including Pi sensing (the 
      so-called transceptor) and a crucial role in Pi metabolism, where they control 
      several phenotypes, such as virulence in pathogens and tumour aggressiveness in 
      cancer cells. Thus, intracellular Pi concentration should be tightly regulated by 
      the fine control of intake and storage in organelles. Pi transporters are 
      classified into two groups: the Pi transporter (PiT) family, also known as the 
      Pi:Na(+) symporter family; and the Pi:H(+) symporter (PHS) family. Highly 
      proliferative cells, such as protozoan parasites and cancer cells, rely on 
      aerobic glycolysis to support the rapid generation of biomass, which is equated 
      with the well-known Warburg effect in cancer cells. In protozoan parasite cells, 
      Pi transporters are strongly associated with cell proliferation, possibly through 
      their action as intracellular Pi suppliers for glyceraldehyde-3-phosphate 
      dehydrogenase (GAPDH) activity. Similarly, the growth rate hypothesis (GRH) 
      proposes that the high Pi demands of tumours when achieving accelerated 
      proliferation are mainly due to increased allocation to P-rich nucleic acids. The 
      purpose of this review was to highlight recent advances in understanding the role 
      of Pi transporters in unicellular eukaryotes and tumorigenic cells, correlating 
      these roles with metabolism in these cells.
FAU - Lacerda-Abreu, Marco Antonio
AU  - Lacerda-Abreu MA
AD  - Leopoldo de Meis Institute of Medical Biochemistry, Federal University of Rio de 
      Janeiro, Rio de Janeiro 21941-902, Brazil.
FAU - Dick, Claudia Fernanda
AU  - Dick CF
AD  - National Center of Structural Biology and Bioimaging (CENABIO), Federal 
      University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
FAU - Meyer-Fernandes, Jose Roberto
AU  - Meyer-Fernandes JR
AD  - Leopoldo de Meis Institute of Medical Biochemistry, Federal University of Rio de 
      Janeiro, Rio de Janeiro 21941-902, Brazil.
LA  - eng
GR  - 401134/2014-8/National Council for Scientific and Technological Development/
GR  - 0012017/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/
GR  - e-26/201.300/2014/Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do 
      Rio de Janeiro/
PT  - Journal Article
PT  - Review
DEP - 20221229
PL  - Switzerland
TA  - Membranes (Basel)
JT  - Membranes
JID - 101577807
PMC - PMC9860751
OTO - NOTNLM
OT  - Apicomplexa
OT  - Pi transporters
OT  - breast cancer cells
OT  - cellular metabolism
OT  - trypanosomatids
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/22 06:00
MHDA- 2023/01/22 06:01
PMCR- 2022/12/29
CRDT- 2023/01/21 01:38
PHST- 2022/10/18 00:00 [received]
PHST- 2022/12/01 00:00 [revised]
PHST- 2022/12/26 00:00 [accepted]
PHST- 2023/01/21 01:38 [entrez]
PHST- 2023/01/22 06:00 [pubmed]
PHST- 2023/01/22 06:01 [medline]
PHST- 2022/12/29 00:00 [pmc-release]
AID - membranes13010042 [pii]
AID - membranes-13-00042 [pii]
AID - 10.3390/membranes13010042 [doi]
PST - epublish
SO  - Membranes (Basel). 2022 Dec 29;13(1):42. doi: 10.3390/membranes13010042.