PMID- 36676939
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230201
IS  - 2218-1989 (Print)
IS  - 2218-1989 (Electronic)
IS  - 2218-1989 (Linking)
VI  - 13
IP  - 1
DP  - 2022 Dec 21
TI  - HIIT Ameliorates Inflammation and Lipid Metabolism by Regulating Macrophage 
      Polarization and Mitochondrial Dynamics in the Liver of Type 2 Diabetes Mellitus 
      Mice.
LID - 10.3390/metabo13010014 [doi]
LID - 14
AB  - High-intensity interval training (HIIT), a new type of exercise, can effectively 
      prevent the progression of metabolic diseases. The aim of this study was to 
      investigate the effects of HIIT on liver inflammation and metabolic disorders in 
      type 2 diabetes mellitus (T2DM) mice induced by a high-fat diet (HFD) combined 
      with streptozotocin (STZ) and to explore the possible mechanisms of macrophage 
      polarization and mitochondrial dynamics. Our results showed that HIIT can 
      increase fatty acid oxidation-related gene (PPARalpha, CPT1alpha, and ACOX1) mRNA levels 
      and decrease adipogenesis-related gene (PPARgamma) mRNA levels to improve liver 
      metabolism in T2DM mice. The improvement of lipid metabolism disorder may occur 
      through increasing liver mitochondrial biosynthesis-related genes (PGC-1alpha and 
      TFAM) and restoring mitochondrial dynamics-related gene (MFN2 and DRP1) mRNA 
      levels. HIIT can also reduce the mRNA levels of liver inflammatory factors 
      (TNF-alpha, IL-6, and MCP-1) in T2DM mice. The reduction in liver inflammation may 
      occur through reducing the expression of total macrophage marker (F4/80) and M1 
      macrophage marker (CD86) mRNA and protein and increasing the expression of M2 
      macrophage marker (CD163, CD206, and Arg1) mRNA and protein in the liver. HIIT 
      can also increase the expression of insulin signaling pathway (IRS1, PI3K, and 
      AKT) mRNA and protein in the liver of T2DM mice, which may be related to the 
      improvements in liver inflammation and lipid metabolism. In conclusion, these 
      results suggested that 8 weeks of HIIT can improve inflammation and lipid 
      metabolism disorders in the liver of type 2 diabetes mellitus mice, macrophage 
      M1/M2 polarization, and mitochondrial dynamics may be involved in this process.
FAU - Wang, Yin
AU  - Wang Y
AD  - Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, 
      Shanghai University of Sport, Shanghai 200438, China.
AD  - The Key Lab of Exercise and Health Sciences of Ministry of Education, Shanghai 
      University of Sport, Shanghai 200438, China.
AD  - Department of Rehabilitation Medicine, Shanghai Sixth People's Hospital 
      Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, 
      China.
FAU - Guo, Yifan
AU  - Guo Y
AD  - Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, 
      Shanghai University of Sport, Shanghai 200438, China.
AD  - The Key Lab of Exercise and Health Sciences of Ministry of Education, Shanghai 
      University of Sport, Shanghai 200438, China.
FAU - Xu, Yingying
AU  - Xu Y
AD  - Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, 
      Shanghai University of Sport, Shanghai 200438, China.
AD  - The Key Lab of Exercise and Health Sciences of Ministry of Education, Shanghai 
      University of Sport, Shanghai 200438, China.
FAU - Wang, Wenhong
AU  - Wang W
AD  - Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, 
      Shanghai University of Sport, Shanghai 200438, China.
AD  - The Key Lab of Exercise and Health Sciences of Ministry of Education, Shanghai 
      University of Sport, Shanghai 200438, China.
FAU - Zhuang, Shuzhao
AU  - Zhuang S
AD  - Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, 
      Shanghai University of Sport, Shanghai 200438, China.
AD  - The Key Lab of Exercise and Health Sciences of Ministry of Education, Shanghai 
      University of Sport, Shanghai 200438, China.
FAU - Wang, Ru
AU  - Wang R
AD  - Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, 
      Shanghai University of Sport, Shanghai 200438, China.
AD  - The Key Lab of Exercise and Health Sciences of Ministry of Education, Shanghai 
      University of Sport, Shanghai 200438, China.
FAU - Xiao, Weihua
AU  - Xiao W
AD  - Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, 
      Shanghai University of Sport, Shanghai 200438, China.
AD  - The Key Lab of Exercise and Health Sciences of Ministry of Education, Shanghai 
      University of Sport, Shanghai 200438, China.
LA  - eng
GR  - NO. 11DZ2261100/Shanghai Key Lab of Human Performance (Shanghai University of 
      sport)/
GR  - 20SG50/"Shuguang Program" (20SG50) funded by Shanghai Education 
      Development Foundation and Shanghai Municipale Education Commission/
PT  - Journal Article
DEP - 20221221
PL  - Switzerland
TA  - Metabolites
JT  - Metabolites
JID - 101578790
PMC - PMC9862084
OTO - NOTNLM
OT  - hepatic steatosis
OT  - high-intensity interval training
OT  - liver inflammation
OT  - liver macrophages
OT  - mitochondria
OT  - type 2 diabetes mellitus
COIS- The authors declare that they have no conflict of interest.
EDAT- 2023/01/22 06:00
MHDA- 2023/01/22 06:01
PMCR- 2022/12/21
CRDT- 2023/01/21 01:39
PHST- 2022/11/27 00:00 [received]
PHST- 2022/12/16 00:00 [revised]
PHST- 2022/12/19 00:00 [accepted]
PHST- 2023/01/21 01:39 [entrez]
PHST- 2023/01/22 06:00 [pubmed]
PHST- 2023/01/22 06:01 [medline]
PHST- 2022/12/21 00:00 [pmc-release]
AID - metabo13010014 [pii]
AID - metabolites-13-00014 [pii]
AID - 10.3390/metabo13010014 [doi]
PST - epublish
SO  - Metabolites. 2022 Dec 21;13(1):14. doi: 10.3390/metabo13010014.