PMID- 36676985
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230201
IS  - 2218-1989 (Print)
IS  - 2218-1989 (Electronic)
IS  - 2218-1989 (Linking)
VI  - 13
IP  - 1
DP  - 2022 Dec 30
TI  - Obstructive Sleep Apnea, Circadian Clock Disruption, and Metabolic Consequences.
LID - 10.3390/metabo13010060 [doi]
LID - 60
AB  - Obstructive sleep apnea (OSA) is a chronic disorder characterized by recurrent 
      episodes of apnea and hypopnea during sleep. It is associated with various 
      cardiovascular and metabolic complications, including type 2 diabetes mellitus 
      (T2DM) and obesity. Many pathways can be responsible for T2DM development in OSA 
      patients, e.g., those related to HIF-1 and SIRT1 expression. Moreover, epigenetic 
      mechanisms, such as miRNA181a or miRNA199, are postulated to play a pivotal role 
      in this link. It has been proven that OSA increases the occurrence of circadian 
      clock disruption, which is also a risk factor for metabolic disease development. 
      Circadian clock disruption impairs the metabolism of glucose, lipids, and the 
      secretion of bile acids. Therefore, OSA-induced circadian clock disruption may be 
      a potential, complex, underlying pathway involved in developing and exacerbating 
      metabolic diseases among OSA patients. The current paper summarizes the available 
      information pertaining to the relationship between OSA and circadian clock 
      disruption in the context of potential mechanisms leading to metabolic disorders.
FAU - Malicki, Mikolaj
AU  - Malicki M
AD  - Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 
      92-215 Lodz, Poland.
FAU - Karuga, Filip Franciszek
AU  - Karuga FF
AUID- ORCID: 0000-0002-6551-6804
AD  - Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 
      92-215 Lodz, Poland.
FAU - Szmyd, Bartosz
AU  - Szmyd B
AUID- ORCID: 0000-0002-4051-0887
AD  - Department of Pediatrics, Oncology, and Hematology, Medical University of Lodz, 
      91-738 Lodz, Poland.
AD  - Department of Neurosurgery, Spine and Peripheral Nerves Surgery, Medical 
      University of Lodz, 90-549 Lodz, Poland.
FAU - Sochal, Marcin
AU  - Sochal M
AUID- ORCID: 0000-0003-2122-0304
AD  - Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 
      92-215 Lodz, Poland.
FAU - Gabryelska, Agata
AU  - Gabryelska A
AUID- ORCID: 0000-0002-4430-6488
AD  - Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 
      92-215 Lodz, Poland.
LA  - eng
GR  - 2021/41/N/NZ5/00486/National Science Center/
PT  - Journal Article
PT  - Review
DEP - 20221230
PL  - Switzerland
TA  - Metabolites
JT  - Metabolites
JID - 101578790
PMC - PMC9863434
OTO - NOTNLM
OT  - OSA
OT  - circadian disruption
OT  - diabetes mellitus
OT  - metabolic complications
OT  - microRNA
OT  - obesity
COIS- Authors declare no conflict of interest.
EDAT- 2023/01/22 06:00
MHDA- 2023/01/22 06:01
PMCR- 2022/12/30
CRDT- 2023/01/21 01:39
PHST- 2022/12/12 00:00 [received]
PHST- 2022/12/26 00:00 [revised]
PHST- 2022/12/27 00:00 [accepted]
PHST- 2023/01/21 01:39 [entrez]
PHST- 2023/01/22 06:00 [pubmed]
PHST- 2023/01/22 06:01 [medline]
PHST- 2022/12/30 00:00 [pmc-release]
AID - metabo13010060 [pii]
AID - metabolites-13-00060 [pii]
AID - 10.3390/metabo13010060 [doi]
PST - epublish
SO  - Metabolites. 2022 Dec 30;13(1):60. doi: 10.3390/metabo13010060.