PMID- 36677008
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230124
IS  - 2218-1989 (Print)
IS  - 2218-1989 (Electronic)
IS  - 2218-1989 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Jan 4
TI  - Biomarkers of Drug Resistance in Temporal Lobe Epilepsy in Adults.
LID - 10.3390/metabo13010083 [doi]
LID - 83
AB  - Temporal lobe epilepsy (TLE) is the most common type of focal epilepsy in adults. 
      Experimental and clinical data indicate that neuroinflammation and 
      neurodegeneration accompanying epileptogenesis make a significant contribution to 
      the chronicity of epilepsy and the development of drug resistance in TLE cases. 
      Changes in plasma and serum concentrations of proteins associated with 
      neuroinflammation and neurodegeneration can be predictive biomarkers of the 
      course of the disease. This study used an enzyme-linked immunosorbent assay of 
      the following plasma proteins: brain-derived neurotrophic factor (BDNF), tumor 
      necrosis factor alpha (TNFa), and high-mobility group protein B1 (HMGB1) in 
      patients with mesial TLE to search for biomarkers of the disease. The objective 
      of the study was to examine biomarkers of the neuroinflammation and 
      neurodegeneration of plasma: BDNF, TNFa, and HMGB1. The aim of the study was to 
      identify changes in the concentration of circulating pro-inflammatory and 
      neurotrophic factors that are prognostically significant for the development of 
      drug resistance and the course of TLE. A decrease in the concentration of BDNF, 
      TNFa, and HMGB1 was registered in the group of patients with TLE compared with 
      the control group. A significant decrease in the concentration of HMGB1 in 
      patients with drug-resistant TLE was observed. Aberrations in plasma 
      concentrations of BDNF, TNFa, and HMGB1 in patients with TLE compared with the 
      controls have been confirmed by earlier studies. A decrease in the expression of 
      the three biomarkers may be the result of neurodegenerative processes caused by 
      the long course of the disease. The results of the study may indicate the 
      acceptability of using HMGB1 and TNFa as prognostic biological markers to 
      indicate the severity of the disease course and the risk of developing drug 
      resistance.
FAU - Panina, Yulia S
AU  - Panina YS
AD  - Department of Medical Genetics and Clinical Neurophysiology, Institute of 
      Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical 
      University, 660022 Krasnoyarsk, Russia.
FAU - Timechko, Elena E
AU  - Timechko EE
AD  - Department of Medical Genetics and Clinical Neurophysiology, Institute of 
      Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical 
      University, 660022 Krasnoyarsk, Russia.
FAU - Usoltseva, Anna A
AU  - Usoltseva AA
AUID- ORCID: 0000-0002-9678-6719
AD  - Department of Medical Genetics and Clinical Neurophysiology, Institute of 
      Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical 
      University, 660022 Krasnoyarsk, Russia.
FAU - Yakovleva, Kristina D
AU  - Yakovleva KD
AUID- ORCID: 0000-0002-2728-5830
AD  - Department of Medical Genetics and Clinical Neurophysiology, Institute of 
      Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical 
      University, 660022 Krasnoyarsk, Russia.
FAU - Kantimirova, Elena A
AU  - Kantimirova EA
AD  - Department of Medical Genetics and Clinical Neurophysiology, Institute of 
      Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical 
      University, 660022 Krasnoyarsk, Russia.
FAU - Dmitrenko, Diana V
AU  - Dmitrenko DV
AUID- ORCID: 0000-0003-4639-6365
AD  - Department of Medical Genetics and Clinical Neurophysiology, Institute of 
      Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical 
      University, 660022 Krasnoyarsk, Russia.
LA  - eng
PT  - Journal Article
DEP - 20230104
PL  - Switzerland
TA  - Metabolites
JT  - Metabolites
JID - 101578790
PMC - PMC9866293
OTO - NOTNLM
OT  - biomarkers
OT  - drug resistance
OT  - neurodegeneration
OT  - neuroinflammation
OT  - temporal lobe epilepsy
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/22 06:00
MHDA- 2023/01/22 06:01
PMCR- 2023/01/04
CRDT- 2023/01/21 01:39
PHST- 2022/11/24 00:00 [received]
PHST- 2022/12/26 00:00 [revised]
PHST- 2023/01/01 00:00 [accepted]
PHST- 2023/01/21 01:39 [entrez]
PHST- 2023/01/22 06:00 [pubmed]
PHST- 2023/01/22 06:01 [medline]
PHST- 2023/01/04 00:00 [pmc-release]
AID - metabo13010083 [pii]
AID - metabolites-13-00083 [pii]
AID - 10.3390/metabo13010083 [doi]
PST - epublish
SO  - Metabolites. 2023 Jan 4;13(1):83. doi: 10.3390/metabo13010083.