PMID- 36677456
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230201
IS  - 2076-2607 (Print)
IS  - 2076-2607 (Electronic)
IS  - 2076-2607 (Linking)
VI  - 11
IP  - 1
DP  - 2023 Jan 8
TI  - Metabolic Engineering of Bacillus subtilis for Riboflavin Production: A Review.
LID - 10.3390/microorganisms11010164 [doi]
LID - 164
AB  - Riboflavin (vitamin B(2)) is one of the essential vitamins that the human body 
      needs to maintain normal metabolism. Its biosynthesis has become one of the 
      successful models for gradual replacement of traditional chemical production 
      routes. B. subtilis is characterized by its short fermentation time and high 
      yield, which shows a huge competitive advantage in microbial fermentation for 
      production of riboflavin. This review summarized the advancements of regulation 
      on riboflavin production as well as the synthesis of two precursors of 
      ribulose-5-phosphate riboflavin (Ru5P) and guanosine 5'-triphosphate (GTP) in B. 
      subtilis. The different strategies to improve production of riboflavin by 
      metabolic engineering were also reviewed.
FAU - Liu, Yang
AU  - Liu Y
AD  - Key Laboratory of Biofuels and Biochemical Engineering, SINOPEC (Dalian) Research 
      Institute of Petroleum and Petro-Chemicals Co., Ltd., Dalian 116045, China.
AD  - CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State 
      Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of 
      Sciences, Beijing 100101, China.
FAU - Zhang, Quan
AU  - Zhang Q
AD  - Key Laboratory of Biofuels and Biochemical Engineering, SINOPEC (Dalian) Research 
      Institute of Petroleum and Petro-Chemicals Co., Ltd., Dalian 116045, China.
FAU - Qi, Xiaoxiao
AU  - Qi X
AD  - CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State 
      Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of 
      Sciences, Beijing 100101, China.
AD  - School of Life Science, University of Chinese Academy of Sciences, Beijing 
      100049, China.
FAU - Gao, Huipeng
AU  - Gao H
AD  - Key Laboratory of Biofuels and Biochemical Engineering, SINOPEC (Dalian) Research 
      Institute of Petroleum and Petro-Chemicals Co., Ltd., Dalian 116045, China.
FAU - Wang, Meng
AU  - Wang M
AD  - Key Laboratory of Biofuels and Biochemical Engineering, SINOPEC (Dalian) Research 
      Institute of Petroleum and Petro-Chemicals Co., Ltd., Dalian 116045, China.
FAU - Guan, Hao
AU  - Guan H
AD  - Key Laboratory of Biofuels and Biochemical Engineering, SINOPEC (Dalian) Research 
      Institute of Petroleum and Petro-Chemicals Co., Ltd., Dalian 116045, China.
FAU - Yu, Bo
AU  - Yu B
AUID- ORCID: 0000-0003-3148-0986
AD  - CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State 
      Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of 
      Sciences, Beijing 100101, China.
LA  - eng
GR  - 2018YFA0902101/National Key Research & Development Project of China/
PT  - Journal Article
PT  - Review
DEP - 20230108
PL  - Switzerland
TA  - Microorganisms
JT  - Microorganisms
JID - 101625893
PMC - PMC9863419
OTO - NOTNLM
OT  - Bacillus subtilis
OT  - biosynthesis
OT  - metabolic engineering
OT  - riboflavin
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/22 06:00
MHDA- 2023/01/22 06:01
PMCR- 2023/01/08
CRDT- 2023/01/21 01:42
PHST- 2022/12/19 00:00 [received]
PHST- 2022/12/30 00:00 [revised]
PHST- 2023/01/02 00:00 [accepted]
PHST- 2023/01/21 01:42 [entrez]
PHST- 2023/01/22 06:00 [pubmed]
PHST- 2023/01/22 06:01 [medline]
PHST- 2023/01/08 00:00 [pmc-release]
AID - microorganisms11010164 [pii]
AID - microorganisms-11-00164 [pii]
AID - 10.3390/microorganisms11010164 [doi]
PST - epublish
SO  - Microorganisms. 2023 Jan 8;11(1):164. doi: 10.3390/microorganisms11010164.