PMID- 36677579
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20230123
LR  - 20230124
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 28
IP  - 2
DP  - 2023 Jan 5
TI  - Application of Cotton Swab-Ag Composite as Flexible Surface-Enhanced Raman 
      Scattering Substrate for DMMP Detection.
LID - 10.3390/molecules28020520 [doi]
LID - 520
AB  - It is both important and required to quickly and accurately detect chemical 
      warfare agents, such as the highly toxic nerve agent sarin. Surface-enhanced 
      Raman scattering (SERS) has received considerable attention due to its rapid 
      results, high sensitivity, non-destructive data acquisition, and unique 
      spectroscopic fingerprint. In this work, we successfully prepared SERS cotton 
      swabs (CSs) for the detection of the sarin simulant agent dimethyl methyl 
      phosphonate (DMMP) by anchoring N1-(3-trimethoxysilylpropyl) diethylenetriamine 
      (ATS)/silver nanoparticle (AgNP) nanocomposites on CSs using ATS as the 
      stabilizer and coupling agent. Simultaneously, the binding mode and reaction 
      mechanics between the AgNP, ATS, and CS were confirmed by XPS. The modified CSs 
      exhibited good uniformity, stability, and adsorption capability for SERS 
      measurements, enabling the adsorption and detection of DMMP residue from an 
      irregular surface via a simple swabbing process, with a detection limit of 1 g/L. 
      The relative standard deviations (RSDs) of RSD(710) = 5.6% had high 
      reproducibility. In this research, the fabrication method could easily be 
      extended to other cellulose compounds, such as natural fibers and paper. 
      Furthermore, the versatile SERS CSs can be used for the on-site detection of 
      DMMP, particularly in civil and defense applications, to guarantee food security 
      and the health of the population.
FAU - Huang, Wen-Chien
AU  - Huang WC
AUID- ORCID: 0000-0002-8163-3314
AD  - Department of Chemical and Materials Engineering, Chung Cheng Institute of 
      Technology, National Defense University, Taoyuan 33551, Taiwan.
FAU - Chen, Hong-Ru
AU  - Chen HR
AD  - Department of Chemical and Materials Engineering, Chung Cheng Institute of 
      Technology, National Defense University, Taoyuan 33551, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20230105
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
SB  - IM
PMC - PMC9860652
OTO - NOTNLM
OT  - SERS cotton swab
OT  - chemical warfare agent simulant (DMMP)
OT  - silver nanoparticles
OT  - versatile SERS substrate
COIS- The authors declare that there is no conflict of interest.
EDAT- 2023/01/22 06:00
MHDA- 2023/01/22 06:01
PMCR- 2023/01/05
CRDT- 2023/01/21 01:42
PHST- 2022/12/07 00:00 [received]
PHST- 2022/12/27 00:00 [revised]
PHST- 2023/01/03 00:00 [accepted]
PHST- 2023/01/21 01:42 [entrez]
PHST- 2023/01/22 06:00 [pubmed]
PHST- 2023/01/22 06:01 [medline]
PHST- 2023/01/05 00:00 [pmc-release]
AID - molecules28020520 [pii]
AID - molecules-28-00520 [pii]
AID - 10.3390/molecules28020520 [doi]
PST - epublish
SO  - Molecules. 2023 Jan 5;28(2):520. doi: 10.3390/molecules28020520.