PMID- 36677719
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20230123
LR  - 20230124
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 28
IP  - 2
DP  - 2023 Jan 9
TI  - Chiral Covalent-Organic Framework MDI-beta-CD-Modified COF@SiO(2) Core-Shell 
      Composite for HPLC Enantioseparation.
LID - 10.3390/molecules28020662 [doi]
LID - 662
AB  - The chiral covalent-organic framework (CCOF) is a new kind of chiral porous 
      material, which has been broadly applied in many fields owing to its high 
      porosity, regular pores, and structural adjustability. However, conventional CCOF 
      particles have the characteristics of irregular morphology and inhomogeneous 
      particle size distribution, which lead to difficulties in fabricating 
      chromatographic columns and high column backpressure when the pure CCOFs 
      particles are directly used as the HPLC stationary phases. Herein, we used an in 
      situ growth strategy to prepare core-shell composite by immobilizing 
      MDI-beta-CD-modified COF on the surface of SiO(2)-NH(2). The synthesized 
      MDI-beta-CD-modified COF@SiO(2) was utilized as a novel chiral stationary phase 
      (CSP) to explore its enantiomeric-separation performance in HPLC. The separation 
      of racemates and positional isomers on MDI-beta-CD-modified COF@SiO(2)-packed column 
      (column A) utilizing n-hexane/isopropanol as the mobile phase was investigated. 
      The results demonstrated that column A displayed remarkable separation ability 
      for racemic compounds and positional isomers with good reproducibility and 
      stability. By comparing the MDI-beta-CD-modified COF@SiO(2)-packed column (column A) 
      with commercial Chiralpak AD-H column and the previously reported 
      beta-CD-COF@SiO(2)-packed column (column B), the chiral recognition ability of 
      column A can be complementary to that of Chiralpak AD-H column and column B. The 
      relative standard deviations (RSDs) of the retention time and peak area for the 
      separation of 1,2-bis(4-fluorophenyl)-2-hydroxyethanone were 0.28% and 0.79%, 
      respectively. Hence, the synthesis of CCOFs@SiO(2) core-shell composites as the 
      CSPs for chromatographic separation has significant research potential and 
      application prospects.
FAU - Ran, Xiaoyan
AU  - Ran X
AD  - Department of Chemistry, Yunnan Normal University, Kunming 650500, China.
FAU - Guo, Ping
AU  - Guo P
AD  - Department of Chemistry, Yunnan Normal University, Kunming 650500, China.
FAU - Liu, Caifang
AU  - Liu C
AD  - Department of Chemistry, Yunnan Normal University, Kunming 650500, China.
FAU - Zhu, Yulan
AU  - Zhu Y
AD  - Department of Chemistry, Yunnan Normal University, Kunming 650500, China.
FAU - Liu, Cheng
AU  - Liu C
AD  - Department of Chemistry, Yunnan Normal University, Kunming 650500, China.
FAU - Wang, Bangjin
AU  - Wang B
AD  - Department of Chemistry, Yunnan Normal University, Kunming 650500, China.
FAU - Zhang, Junhui
AU  - Zhang J
AD  - Department of Chemistry, Yunnan Normal University, Kunming 650500, China.
FAU - Xie, Shengming
AU  - Xie S
AD  - Department of Chemistry, Yunnan Normal University, Kunming 650500, China.
FAU - Yuan, Liming
AU  - Yuan L
AD  - Department of Chemistry, Yunnan Normal University, Kunming 650500, China.
LA  - eng
GR  - Nos. 21964021, and 22064020/the National Natural Science Foun-dation of China 
      (Nos. 21964021, and 22064020)/
GR  - Nos. 202201AT070029, and 202101AT07010/the Applied Basic Research Foundation of 
      Yunnan Province (Nos. 202201AT070029, and 202101AT070101)/
PT  - Journal Article
DEP - 20230109
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
SB  - IM
PMC - PMC9866547
OTO - NOTNLM
OT  - chiral covalent-organic frameworks
OT  - chiral separation
OT  - core-shell composites
OT  - high-performance liquid chromatography
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/22 06:00
MHDA- 2023/01/22 06:01
PMCR- 2023/01/09
CRDT- 2023/01/21 01:43
PHST- 2022/11/28 00:00 [received]
PHST- 2022/12/26 00:00 [revised]
PHST- 2023/01/03 00:00 [accepted]
PHST- 2023/01/21 01:43 [entrez]
PHST- 2023/01/22 06:00 [pubmed]
PHST- 2023/01/22 06:01 [medline]
PHST- 2023/01/09 00:00 [pmc-release]
AID - molecules28020662 [pii]
AID - molecules-28-00662 [pii]
AID - 10.3390/molecules28020662 [doi]
PST - epublish
SO  - Molecules. 2023 Jan 9;28(2):662. doi: 10.3390/molecules28020662.