PMID- 36679153
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230201
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 15
IP  - 2
DP  - 2023 Jan 5
TI  - Synthesis and Characterization of 𝒌-Carrageenan/PVA Nanocomposite Hydrogels in 
      Combination with MgZnO Nanoparticles to Evaluate the Catechin Release.
LID - 10.3390/polym15020272 [doi]
LID - 272
AB  - In the current study, nanocomposites were prepared by combining k-carrageenan, 
      polyvinyl alcohol (PVA), and doped nanoparticles (Magnesium oxide) MgO, 
      (Magnesium Zinc oxide) MgZnO 1%, MgZnO 3%, and MgZnO 5%. The nanoparticles were 
      synthesized by a sol-gel method and mixed with a mixture of k-carrageenan/PVA 
      (Ca/PVA) in various ratios. The structure of the composites was analyzed using 
      thermogravimetric analysis (TGA), X-ray diffraction (XRD), and Fourier transform 
      infrared spectroscopy (FTIR). The Ca/PVA mixture was then mixed with 
      nanoparticles and loaded with active ingredient, catechin. Scanning electron 
      microscope (SEM) and texture analysis were performed to analyze the 
      nanocomposites. Entrapment efficiency (EE%) and drug release studies confirmed 
      that k-carrageenan/PVA/MgZnO 5% had the highest EE% at 81.58% and a drug release 
      of 75.21% +/- 0.94. The EE% of k-carrageenan/PVA/MgO was 55.21% and its drug 
      release was 45%. This indicates that ZnO plays an effective role in the structure 
      and performance of Ca/PVA composites. The SEM images of MgO composites show 
      smoother surfaces compared to MgZnO composites. This may be one of the reasons 
      for the increased EE% and drug release of MgZnO composites. The addition of ZnO 
      to the composite structure can lead to the appearance of pores on the surface of 
      the composite, increasing entrapment and drug release.
FAU - Sabbagh, Farzaneh
AU  - Sabbagh F
AUID- ORCID: 0000-0002-2274-3855
AD  - Department of Botany and Plant Science, Faculty of Biological Science, Alzahra 
      University, Tehran 1993891176, Iran.
AD  - Department of Chemical Engineering, Chungbuk National University, Cheongju 28644, 
      Republic of Korea.
FAU - Khatir, Nadia Mahmoudi
AU  - Khatir NM
AUID- ORCID: 0000-0002-8176-1535
AD  - Department of Biotechnology, Faculty of Biological Science, Alzahra University, 
      Tehran 1993891176, Iran.
FAU - Kiarostami, Khadijeh
AU  - Kiarostami K
AD  - Department of Botany and Plant Science, Faculty of Biological Science, Alzahra 
      University, Tehran 1993891176, Iran.
LA  - eng
PT  - Journal Article
DEP - 20230105
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC9864035
OTO - NOTNLM
OT  - ?-carrageenan
OT  - drug release
OT  - nanoparticle
OT  - polyvinyl alcohol
OT  - sol-gel
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/22 06:00
MHDA- 2023/01/22 06:01
PMCR- 2023/01/05
CRDT- 2023/01/21 01:52
PHST- 2022/11/21 00:00 [received]
PHST- 2022/12/27 00:00 [revised]
PHST- 2023/01/01 00:00 [accepted]
PHST- 2023/01/21 01:52 [entrez]
PHST- 2023/01/22 06:00 [pubmed]
PHST- 2023/01/22 06:01 [medline]
PHST- 2023/01/05 00:00 [pmc-release]
AID - polym15020272 [pii]
AID - polymers-15-00272 [pii]
AID - 10.3390/polym15020272 [doi]
PST - epublish
SO  - Polymers (Basel). 2023 Jan 5;15(2):272. doi: 10.3390/polym15020272.