PMID- 36679166
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 15
IP  - 2
DP  - 2023 Jan 5
TI  - The Chemotherapeutic Efficacy of Hyaluronic Acid Coated Polymeric Nanoparticles 
      against Breast Cancer Metastasis in Female NCr-Nu/Nu Nude Mice.
LID - 10.3390/polym15020284 [doi]
LID - 284
AB  - Polyethylene glycol (PEG) coated Poly lactic-co-glycolic acid (PLGA) 
      nanoparticles (NPs) for cancer treatment are biocompatible, nonimmunogenic and 
      accumulate in tumour sites due to the enhanced permeability and retention (EPR). 
      Doxorubicin (DOX) is a potent but cardiotoxic anticancer agent. Hyaluronic acid 
      (HA) occurs naturally in the extra-cellar matrix and binds to CD44 receptors 
      which are overexpressed in cancer metastasis, proven to be characteristic of 
      cancer stem cells and responsible for multidrug resistance. In this study, an 
      athymic mice model of breast cancer metastasis was developed using red 
      fluorescent protein (RFP)-labelled triple negative cancer cells. The animals were 
      divided into four treatment groups (Control, HA-PEG-PLGA nanoparticles, PEG-PLGA 
      nanoparticles, and Free DOX). The tumour size growth was assessed until day 25 
      when animals were sacrificed. Mice treated with HA-PEG-PLGA NPs inhibited tumour 
      growth. The tumour growth at day 25 (118% +/- 13.0) was significantly (p < 0.05) 
      less than PEG-PLGA NPs (376% +/- 590 and control (826% +/- 970). Fluorescent 
      microscopy revealed that HA-PEG-PLGA NPs had significantly (p < 0.05) less 
      metastasis in liver, spleen, colon, and lungs as compared to control and to Free 
      DOX groups. The efficacy of HA-PEG-PLGA NPs was proven in vivo. Further 
      pharmacokinetic and toxicity studies are required for this formulation to be 
      ready for clinical research.
FAU - Almoustafa, Hassan A
AU  - Almoustafa HA
AD  - Department of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 
      50603, Malaysia.
FAU - Alshawsh, Mohammed Abdullah
AU  - Alshawsh MA
AUID- ORCID: 0000-0001-8342-5183
AD  - Department of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 
      50603, Malaysia.
FAU - Al-Suede, Fouad Saleih R
AU  - Al-Suede FSR
AUID- ORCID: 0000-0003-1816-6722
AD  - EMAN Biodiscoveries Sdn. Bhd., A1-4, Lot 5, Persiaran 2/1, Kedah Halal Park, 
      Kawasan Perindustrian Sungai Petani, Sungai Petani 08000, Malaysia.
FAU - Alshehade, Salah Abdulrazak
AU  - Alshehade SA
AUID- ORCID: 0000-0001-8732-1883
AD  - Faculty of Bioeconomic & Health Sciences, University Geomatika Malaysia, Kuala 
      Lumpur 54200, Malaysia.
FAU - Abdul Majid, Amin Malik Shah
AU  - Abdul Majid AMS
AUID- ORCID: 0000-0001-7499-2258
AD  - EMAN Biodiscoveries Sdn. Bhd., A1-4, Lot 5, Persiaran 2/1, Kedah Halal Park, 
      Kawasan Perindustrian Sungai Petani, Sungai Petani 08000, Malaysia.
AD  - ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of 
      Medical Research, Australian National University, 131 Garran Rd., Acton 2601, 
      Australia.
FAU - Chik, Zamri
AU  - Chik Z
AUID- ORCID: 0000-0003-1770-8382
AD  - Department of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 
      50603, Malaysia.
AD  - Faculty of Medicine, Universiti Malaya Bioequivalence and Testing Centre (UBAT), 
      Universiti Malaya, Kuala Lumpur 50603, Malaysia.
LA  - eng
GR  - FP031-2014A/Ministry of Higher Education/
GR  - PRGS PR002-2021/Ministry of Higher Education/
PT  - Journal Article
DEP - 20230105
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC9863707
OTO - NOTNLM
OT  - PEG-PLGA nanoparticles
OT  - athymic mice
OT  - doxorubicin
OT  - hyaluronic acid
OT  - nanoprecipitation
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/22 06:00
MHDA- 2023/01/22 06:01
PMCR- 2023/01/05
CRDT- 2023/01/21 01:52
PHST- 2022/11/10 00:00 [received]
PHST- 2022/12/14 00:00 [revised]
PHST- 2022/12/20 00:00 [accepted]
PHST- 2023/01/21 01:52 [entrez]
PHST- 2023/01/22 06:00 [pubmed]
PHST- 2023/01/22 06:01 [medline]
PHST- 2023/01/05 00:00 [pmc-release]
AID - polym15020284 [pii]
AID - polymers-15-00284 [pii]
AID - 10.3390/polym15020284 [doi]
PST - epublish
SO  - Polymers (Basel). 2023 Jan 5;15(2):284. doi: 10.3390/polym15020284.