PMID- 36679878
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2076-393X (Print)
IS  - 2076-393X (Electronic)
IS  - 2076-393X (Linking)
VI  - 11
IP  - 1
DP  - 2022 Dec 23
TI  - Efficacy and Safety of COVID-19 Vaccination in Older Adults: A Systematic Review 
      and Meta-Analysis.
LID - 10.3390/vaccines11010033 [doi]
LID - 33
AB  - Objective: To analyze the differences in efficacy and safety of different types 
      of novel coronavirus pneumonia (COVID-19) vaccines in different age groups (young 
      adults and elderly). Methods: Randomized controlled trials (RCTs) on COVID-19 
      vaccine in PubMed, Embase, Web of Science, and Cochrane library were searched by 
      computer, and eight eligible studies were analyzed. Meta-analysis was performed 
      using Stata 16.0 and RevMan5.4 software. Results: The mean geometric titer (GMT) 
      of the virus in the elderly was significantly higher than that in the placebo 
      group (SMD = 0.91, 95% CI (0.68, 1.15), p < 0.01), presenting no obvious 
      difference compared with the young adults (SMD = 0.19, 95% CI (0.38, 0.01), p = 
      0.06). Meanwhile, the effect of multiple vaccinations was better than that of 
      single vaccination (SMD = 0.83, 95% CI (0.33, 1.34), p < 0.01). However, the 
      number of adverse events (AEs) in the elderly was lower than that in the young 
      adults (OR = 0.35, 95% CI (0.29, 0.42), p < 0.01). Conclusions: The immunization 
      effect of COVID-19 vaccine in the elderly is obvious, especially after multiple 
      vaccinations, and the incidence of AEs in the elderly is low, which proves that 
      the vaccination of the elderly is safe and effective.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Department of General Medicine, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin 150086, China.
FAU - Jiang, Lihong
AU  - Jiang L
AD  - Department of General Medicine, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin 150086, China.
FAU - Tian, Tian
AU  - Tian T
AD  - Department of Epidemiology, School of Public Health, Harbin Medical University, 
      Harbin 150086, China.
FAU - Li, Wenjing
AU  - Li W
AD  - Department of General Medicine, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin 150086, China.
FAU - Pan, Yonghui
AU  - Pan Y
AD  - Fourth Department of Neurology, The First Affiliated Hospital of Harbin Medical 
      University, Harbin 150001, China.
FAU - Wang, Yongchen
AU  - Wang Y
AD  - Department of General Medicine, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin 150086, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221223
PL  - Switzerland
TA  - Vaccines (Basel)
JT  - Vaccines
JID - 101629355
PMC - PMC9862835
OTO - NOTNLM
OT  - COVID-19
OT  - effectiveness
OT  - elderly
OT  - security
OT  - vaccines
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/22 06:00
MHDA- 2023/01/22 06:01
PMCR- 2022/12/23
CRDT- 2023/01/21 01:56
PHST- 2022/11/16 00:00 [received]
PHST- 2022/12/06 00:00 [revised]
PHST- 2022/12/21 00:00 [accepted]
PHST- 2023/01/21 01:56 [entrez]
PHST- 2023/01/22 06:00 [pubmed]
PHST- 2023/01/22 06:01 [medline]
PHST- 2022/12/23 00:00 [pmc-release]
AID - vaccines11010033 [pii]
AID - vaccines-11-00033 [pii]
AID - 10.3390/vaccines11010033 [doi]
PST - epublish
SO  - Vaccines (Basel). 2022 Dec 23;11(1):33. doi: 10.3390/vaccines11010033.