PMID- 36683511
OWN - NLM
STAT- MEDLINE
DCOM- 20230905
LR  - 20230906
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Print)
IS  - 1387-2877 (Linking)
VI  - 94
IP  - s1
DP  - 2023
TI  - Microglia-Mediated Neurovascular Unit Dysfunction in Alzheimer's Disease.
PG  - S335-S354
LID - 10.3233/JAD-221064 [doi]
AB  - The neurovascular unit (NVU) is involved in the pathological changes in 
      Alzheimer's disease (AD). The NVU is a structural and functional complex that 
      maintains microenvironmental homeostasis and metabolic balance in the central 
      nervous system. As one of the most important components of the NVU, microglia not 
      only induce blood-brain barrier breakdown by promoting neuroinflammation, the 
      infiltration of peripheral white blood cells and oxidative stress but also 
      mediate neurovascular uncoupling by inducing mitochondrial dysfunction in 
      neurons, abnormal contraction of cerebral vessels, and pericyte loss in AD. In 
      addition, microglia-mediated dysfunction of cellular components in the NVU, such 
      as astrocytes and pericytes, can destroy the integrity of the NVU and lead to NVU 
      impairment. Therefore, we review the mechanisms of microglia-mediated NVU 
      dysfunction in AD. Furthermore, existing therapeutic advancements aimed at 
      restoring the function of microglia and the NVU in AD are discussed. Finally, we 
      predict the role of pericytes in microglia-mediated NVU dysfunction in AD is the 
      hotspot in the future.
FAU - Huang, Wenhao
AU  - Huang W
AD  - Department of Biochemistry and Molecular Biology, Harbin Medical University, 
      Harbin, Heilongjiang Province, China.
FAU - Xia, Qing
AU  - Xia Q
AD  - Department of Biochemistry and Molecular Biology, Harbin Medical University, 
      Harbin, Heilongjiang Province, China.
AD  - Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
FAU - Zheng, Feifei
AU  - Zheng F
AD  - Department of Biochemistry and Molecular Biology, Harbin Medical University, 
      Harbin, Heilongjiang Province, China.
FAU - Zhao, Xue
AU  - Zhao X
AD  - Department of Biochemistry and Molecular Biology, Harbin Medical University, 
      Harbin, Heilongjiang Province, China.
FAU - Ge, Fangliang
AU  - Ge F
AD  - Department of Biochemistry and Molecular Biology, Harbin Medical University, 
      Harbin, Heilongjiang Province, China.
FAU - Xiao, Jiaying
AU  - Xiao J
AD  - Department of Biochemistry and Molecular Biology, Harbin Medical University, 
      Harbin, Heilongjiang Province, China.
FAU - Liu, Zijie
AU  - Liu Z
AD  - Department of Biochemistry and Molecular Biology, Harbin Medical University, 
      Harbin, Heilongjiang Province, China.
FAU - Shen, Yingying
AU  - Shen Y
AD  - Department of Biochemistry and Molecular Biology, Harbin Medical University, 
      Harbin, Heilongjiang Province, China.
FAU - Ye, Ke
AU  - Ye K
AD  - Department of Biochemistry and Molecular Biology, Harbin Medical University, 
      Harbin, Heilongjiang Province, China.
FAU - Wang, Dayong
AU  - Wang D
AD  - Department of Biochemistry and Molecular Biology, Harbin Medical University, 
      Harbin, Heilongjiang Province, China.
AD  - Basic Medical Institute, Heilongjiang Medical Science Academy, Harbin, 
      Heilongjiang Province, China.
AD  - Translational Medicine Center of Northern China, Harbin, Heilongjiang Province, 
      China.
AD  - Key Laboratory of Heilongjiang Province for Genetically Modified Animals, Harbin 
      Medical University, Harbin, Heilongjiang Province, China.
FAU - Li, Yanze
AU  - Li Y
AD  - Department of Biochemistry and Molecular Biology, Harbin Medical University, 
      Harbin, Heilongjiang Province, China.
AD  - Basic Medical Institute, Heilongjiang Medical Science Academy, Harbin, 
      Heilongjiang Province, China.
AD  - Translational Medicine Center of Northern China, Harbin, Heilongjiang Province, 
      China.
AD  - Key Laboratory of Heilongjiang Province for Genetically Modified Animals, Harbin 
      Medical University, Harbin, Heilongjiang Province, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
SB  - IM
MH  - Humans
MH  - *Alzheimer Disease/pathology
MH  - Microglia/metabolism
MH  - Blood-Brain Barrier/metabolism
MH  - Astrocytes/metabolism
MH  - Neurons/metabolism
PMC - PMC10473143
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - blood-brain barrier
OT  - microglia
OT  - neurovascular uncoupling
OT  - neurovascular unit
OT  - pericyte
COIS- The authors have no conflict of interest to report.
EDAT- 2023/01/24 06:00
MHDA- 2023/09/05 06:42
PMCR- 2023/09/01
CRDT- 2023/01/23 03:33
PHST- 2023/09/05 06:42 [medline]
PHST- 2023/01/24 06:00 [pubmed]
PHST- 2023/01/23 03:33 [entrez]
PHST- 2023/09/01 00:00 [pmc-release]
AID - JAD221064 [pii]
AID - 10.3233/JAD-221064 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2023;94(s1):S335-S354. doi: 10.3233/JAD-221064.