PMID- 36683754
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231106
IS  - 2056-3418 (Print)
IS  - 2056-3426 (Electronic)
IS  - 2056-3426 (Linking)
VI  - 10
DP  - 2023
TI  - Integrated printed BDNF-stimulated HUCMSCs-derived exosomes/collagen/chitosan 
      biological scaffolds with 3D printing technology promoted the remodelling of 
      neural networks after traumatic brain injury.
PG  - rbac085
LID - 10.1093/rb/rbac085 [doi]
LID - rbac085
AB  - The restoration of nerve dysfunction after traumatic brain injury (TBI) faces 
      huge challenges due to the limited self-regenerative abilities of nerve tissues. 
      In situ inductive recovery can be achieved utilizing biological scaffolds 
      combined with endogenous human umbilical cord mesenchymal stem cells 
      (HUCMSCs)-derived exosomes (MExos). In this study, brain-derived neurotrophic 
      factor-stimulated HUCMSCs-derived exosomes (BMExos) were composited with 
      collagen/chitosan by 3D printing technology. 3D-printed collagen/chitosan/BMExos 
      (3D-CC-BMExos) scaffolds have excellent mechanical properties and 
      biocompatibility. Subsequently, in vivo experiments showed that 3D-CC-BMExos 
      therapy could improve the recovery of neuromotor function and cognitive function 
      in a TBI model in rats. Consistent with the behavioural recovery, the results of 
      histomorphological tests showed that 3D-CC-BMExos therapy could facilitate the 
      remodelling of neural networks, such as improving the regeneration of nerve 
      fibres, synaptic connections and myelin sheaths, in lesions after TBI.
CI  - (c) The Author(s) 2022. Published by Oxford University Press.
FAU - Liu, Xiaoyin
AU  - Liu X
AD  - Department of Neurosurgery, West China Hospital, West China Medical School, 
      Sichuan University, Chengdu, Sichuan 610041, China.
AD  - National Engineering Research Center for Biomaterials, College of Biomedical 
      Engineering, Sichuan University, Chengdu, Sichuan 610064, China.
FAU - Zhang, Jian
AU  - Zhang J
AD  - Tianjin Key Laboratory of Neurotrauma Repair, Institute of Traumatic Brain Injury 
      and Neuroscience, Characteristic Medical Center of Chinese People's Armed Police 
      Force, Tianjin 300162, China.
FAU - Cheng, Xu
AU  - Cheng X
AD  - Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan 610064, China.
FAU - Liu, Peng
AU  - Liu P
AD  - Department of Neurosurgery, West China Hospital, West China Medical School, 
      Sichuan University, Chengdu, Sichuan 610041, China.
FAU - Feng, Qingbo
AU  - Feng Q
AD  - Department of Liver Surgery & Liver Transplantation, State Key Laboratory of 
      Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 
      Sichuan 610041, China.
FAU - Wang, Shan
AU  - Wang S
AD  - Department of Neurosurgery, West China Hospital, West China Medical School, 
      Sichuan University, Chengdu, Sichuan 610041, China.
FAU - Li, Yuanyou
AU  - Li Y
AD  - Department of Neurosurgery, West China Hospital, West China Medical School, 
      Sichuan University, Chengdu, Sichuan 610041, China.
FAU - Gu, Haoran
AU  - Gu H
AD  - The 947th Hospital of Chinese People's Liberation Army, Xinjiang Uygur Autonomous 
      Region, Kashgar 844000, China.
FAU - Zhong, Lin
AU  - Zhong L
AD  - The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 
      610500, China.
FAU - Chen, Miao
AU  - Chen M
AD  - Intensive Care Unit, Traditional Chinese Medicine Hospital of Xinjiang Uyghur 
      Autonomous Region and Affiliated Hospital of Traditional Chinese Medicine of 
      Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830000, 
      China.
FAU - Zhou, Liangxue
AU  - Zhou L
AD  - Department of Neurosurgery, West China Hospital, West China Medical School, 
      Sichuan University, Chengdu, Sichuan 610041, China.
LA  - eng
PT  - Journal Article
DEP - 20221026
PL  - England
TA  - Regen Biomater
JT  - Regenerative biomaterials
JID - 101652150
PMC - PMC9847532
OTO - NOTNLM
OT  - BDNF
OT  - chitosan
OT  - collagen
OT  - exosomes
OT  - mesenchymal stem cell
OT  - traumatic brain injury
EDAT- 2023/01/24 06:00
MHDA- 2023/01/24 06:01
PMCR- 2022/10/26
CRDT- 2023/01/23 04:17
PHST- 2022/07/17 00:00 [received]
PHST- 2022/09/23 00:00 [revised]
PHST- 2022/10/12 00:00 [accepted]
PHST- 2023/01/23 04:17 [entrez]
PHST- 2023/01/24 06:00 [pubmed]
PHST- 2023/01/24 06:01 [medline]
PHST- 2022/10/26 00:00 [pmc-release]
AID - rbac085 [pii]
AID - 10.1093/rb/rbac085 [doi]
PST - epublish
SO  - Regen Biomater. 2022 Oct 26;10:rbac085. doi: 10.1093/rb/rbac085. eCollection 
      2023.