PMID- 36684235
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230201
IS  - 2296-875X (Print)
IS  - 2296-875X (Electronic)
IS  - 2296-875X (Linking)
VI  - 9
DP  - 2022
TI  - The predictive value of revised diastolic dysfunction in outcomes of liver 
      transplantation: A propensity score matching analysis.
PG  - 1072908
LID - 10.3389/fsurg.2022.1072908 [doi]
LID - 1072908
AB  - BACKGROUND: Diastolic dysfunction (DD), one of the earliest signs of cirrhotic 
      cardiomyopathy (CCM), is included in the revised 2019 CCM criteria. Nonetheless, 
      relevant research regarding the effects of revised DD on post-liver 
      transplantation (LT) outcomes remains limited. METHODS: This retrospective study 
      enrolled patients who underwent LT for decompensated cirrhosis, from January 2018 
      to March 2021. Patients were divided into DD and non-DD groups. Clinical data 
      were collected. Patients were followed up with, for at least 1 year post-LT; 
      cardiovascular adverse events (AEs) and survival status were recorded. Risk 
      factors were identified using 1:2 propensity score matching (PSM), after 
      adjusting for confounding factors. The caliper value was set to 0.02. RESULTS: Of 
      231 patients, 153 were diagnosed with DD (male, 81.8%; mean age, 51.5 +/- 9.5 
      years). Nineteen patients with DD died within 1 year, post-LT. After PSM, 97 and 
      60 patients were diagnosed with and without DD, respectively. Patients with DD 
      had longer intensive care unit (ICU) stays, higher perioperative cardiovascular 
      AEs, and higher mortality rates than those without DD. In a multivariate 
      analysis, interventricular septum (IVS), left atrial volume index (LAVI), and 
      potassium levels were independent prognostic factors of perioperative 
      cardiovascular AEs, while a decreased early diastolic mitral annular tissue 
      velocity (e'), increased neutrophil-to-lymphocyte ratio (NLR) and tumor markers 
      were predictors of mortality within 1 year post-LT after PSM (P < 0.05). 
      CONCLUSION: Cardiac DD may contribute to perioperative cardiovascular AEs and 
      mortality post-LT. Clinicians should be aware of decompensated cirrhosis in 
      patients with DD.
CI  - (c) 2023 Bi, Jiang, Zhao, Niu, Liu and Jing.
FAU - Bi, Shenghua
AU  - Bi S
AD  - Gastroenterology Department, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Jiang, Yueping
AU  - Jiang Y
AD  - Gastroenterology Department, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Zhao, Wenjun
AU  - Zhao W
AD  - Gastroenterology Department, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Niu, Xiaoyan
AU  - Niu X
AD  - Department of Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, 
      China.
FAU - Liu, Xuechun
AU  - Liu X
AD  - Gastroenterology Department, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Jing, Xue
AU  - Jing X
AD  - Gastroenterology Department, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
LA  - eng
PT  - Journal Article
DEP - 20230106
PL  - Switzerland
TA  - Front Surg
JT  - Frontiers in surgery
JID - 101645127
PMC - PMC9852983
OTO - NOTNLM
OT  - adverse events
OT  - cirrhotic cardiomyopathy
OT  - decompensated cirrhosis
OT  - liver transplantation
OT  - mortality
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/01/24 06:00
MHDA- 2023/01/24 06:01
PMCR- 2023/01/06
CRDT- 2023/01/23 04:21
PHST- 2022/10/18 00:00 [received]
PHST- 2022/12/12 00:00 [accepted]
PHST- 2023/01/23 04:21 [entrez]
PHST- 2023/01/24 06:00 [pubmed]
PHST- 2023/01/24 06:01 [medline]
PHST- 2023/01/06 00:00 [pmc-release]
AID - 10.3389/fsurg.2022.1072908 [doi]
PST - epublish
SO  - Front Surg. 2023 Jan 6;9:1072908. doi: 10.3389/fsurg.2022.1072908. eCollection 
      2022.