PMID- 36685051
OWN - NLM
STAT- MEDLINE
DCOM- 20230228
LR  - 20240205
IS  - 1555-4317 (Electronic)
IS  - 1555-4309 (Print)
IS  - 1555-4309 (Linking)
VI  - 2022
DP  - 2022
TI  - The Correlation between Type 2 Diabetes and Fat Fraction in Liver and Pancreas: A 
      Study using MR Dixon Technique.
PG  - 7073647
LID - 10.1155/2022/7073647 [doi]
LID - 7073647
AB  - OBJECTIVE: The increased obesity results in ectopic fat deposits in liver and 
      pancreas, which will affect insulin resistance and elevated plasma glucose with 
      type 2 diabetes. To assess the relationship between obesity and ectopic fat 
      deposits and diabetes, this study used the MR Dixon method for the quantification 
      of liver and pancreas fat fraction (FF) in type 2 diabetes mellitus (T2DM) 
      patients and healthy controls. METHODS: The FF of whole liver (FFWL) and pancreas 
      (FFWP), the maximum diameters of the pancreas, the abdominal subcutaneous adipose 
      area (SAT), the visceral adipose tissue area (VAT), and the total abdominal 
      adipose tissue area (TAT) were measured for 157 subjects using the MR Dixon data. 
      Four groups were established on the basis of BMI value. For statistics, intra- 
      and intergroup comparisons were made by employing independent sample t-test. 
      RESULTS: FFWL, FFWP, and VAT varied significantly between T2DM (BMI < 25) and 
      control group (BMI < 25), T2DM (BMI >/= 25) and control group (BMI >/= 25), T2DM 
      (BMI < 25) and T2DM (BMI >/= 25) (all P < 0.05). The FF of pancreas tail, SAT, and 
      TAT varied significantly between control group (BMI < 25) and control group 
      (BMI >/= 25) (P < 0.05). FFWP and the FF of pancreas tail varied significantly 
      between T2DM and normal volunteers (P < 0.05), with normal or mild liver fat 
      content. CONCLUSION: The tissue FF, which has a close relationship with T2DM, can 
      be assessed by the MR Dixon technique. T2DM patients should pay attention to 
      tissue fat content regardless of BMI values.
CI  - Copyright (c) 2022 Yonghong Zheng et al.
FAU - Zheng, Yonghong
AU  - Zheng Y
AUID- ORCID: 0000-0002-5610-2888
AD  - Shengli Clinical Medical College of Fujian Medical University, Fujian, Fuzhou, 
      China.
AD  - Department of Radiology, Fujian Provincial Hospital, Fujian, Fuzhou, China.
FAU - Yang, Shengsheng
AU  - Yang S
AD  - Shengli Clinical Medical College of Fujian Medical University, Fujian, Fuzhou, 
      China.
AD  - Department of Radiology, Fujian Provincial Hospital, Fujian, Fuzhou, China.
FAU - Chen, Xianyuan
AU  - Chen X
AD  - Shengli Clinical Medical College of Fujian Medical University, Fujian, Fuzhou, 
      China.
AD  - Department of Radiology, Fujian Provincial Hospital, Fujian, Fuzhou, China.
FAU - Lv, Jieqin
AU  - Lv J
AD  - Shengli Clinical Medical College of Fujian Medical University, Fujian, Fuzhou, 
      China.
AD  - Department of Radiology, Fujian Provincial Hospital, Fujian, Fuzhou, China.
FAU - Su, Jiawei
AU  - Su J
AD  - Shengli Clinical Medical College of Fujian Medical University, Fujian, Fuzhou, 
      China.
AD  - Department of Radiology, Fujian Provincial Hospital, Fujian, Fuzhou, China.
FAU - Yu, Shun
AU  - Yu S
AUID- ORCID: 0000-0002-9073-3886
AD  - Shengli Clinical Medical College of Fujian Medical University, Fujian, Fuzhou, 
      China.
AD  - Department of Radiology, Fujian Provincial Hospital, Fujian, Fuzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221230
PL  - England
TA  - Contrast Media Mol Imaging
JT  - Contrast media & molecular imaging
JID - 101286760
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/diagnostic imaging
MH  - Insulin Resistance
MH  - *Liver/diagnostic imaging
MH  - Magnetic Resonance Imaging/methods
MH  - Obesity/diagnostic imaging
MH  - *Pancreas/diagnostic imaging
MH  - *Abdominal Fat/diagnostic imaging
PMC - PMC9822734
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2023/01/24 06:00
MHDA- 2023/01/25 06:00
PMCR- 2022/12/30
CRDT- 2023/01/23 04:31
PHST- 2022/10/16 00:00 [received]
PHST- 2022/12/05 00:00 [revised]
PHST- 2022/12/08 00:00 [accepted]
PHST- 2023/01/23 04:31 [entrez]
PHST- 2023/01/24 06:00 [pubmed]
PHST- 2023/01/25 06:00 [medline]
PHST- 2022/12/30 00:00 [pmc-release]
AID - 10.1155/2022/7073647 [doi]
PST - epublish
SO  - Contrast Media Mol Imaging. 2022 Dec 30;2022:7073647. doi: 10.1155/2022/7073647. 
      eCollection 2022.