PMID- 36685216
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 0268-7038 (Print)
IS  - 1464-5041 (Electronic)
IS  - 0268-7038 (Linking)
VI  - 36
IP  - 11
DP  - 2022
TI  - Factors predicting long-term recovery from post-stroke aphasia.
PG  - 1351-1372
LID - 10.1080/02687038.2021.1966374 [doi]
AB  - BACKGROUND: It remains widely accepted that spontaneous recovery from aphasia is 
      largely limited to the first related factors. This has direct implications for 
      acute and chronic interventions for aphasia. few months following stroke. A few 
      recent studies challenge this view, revealing that some individuals' language 
      abilities improve even during the chronic stage. AIMS: To identify prognostic 
      indicators of long-term aphasia recovery. METHODS & PROCEDURES: Eighteen people 
      with aphasia initially evaluated in the chronic stage were retested at least one 
      year later. The Western Aphasia Battery-Revised (WAB-R) Aphasia Quotient (AQ) was 
      used to quantify changes in language impairment. Prognostic factors included 
      those related to the patient (demographic, psychosocial), stroke (lesion volume 
      and location), and treatment (medical, rehabilitative). OUTCOMES & RESULTS: 
      Twelve participants improved and 6 remained stable or declined. Linear regression 
      analysis revealed that lesion volume predicted long-term language gains, with 
      smaller lesions yielding greater improvements. Individuals who did not improve 
      were more likely to have lesions encompassing critical frontal and 
      temporoparietal cortical regions and interconnecting white matter pathways. 
      Exploratory regression analysis of psychosocial and treatment-related factors 
      revealed a positive relationship between improvement and satisfaction with life 
      participation, and a negative relationship between improvement and perceived 
      impairment severity. Critically, psychosocial and treatment-related factors 
      significantly improved model fit over lesion volume, suggesting that these 
      factors add predictive value to determining long-term aphasia prognosis. 
      CONCLUSIONS: Long-term aphasia recovery is multidetermined by a combination of 
      stroke-, psychosocial-, and treatment-related factors. This has direct 
      implications for acute and chronic interventions for aphasia.
FAU - Harvey, Denise Y
AU  - Harvey DY
AD  - Department of Neurology, University of Pennsylvania, Philadelphia, PA.
AD  - Moss Rehabilitation Research Institute, Elkins Park, PA.
FAU - Parchure, Shreya
AU  - Parchure S
AD  - Department of Neurology, University of Pennsylvania, Philadelphia, PA.
FAU - Hamilton, Roy H
AU  - Hamilton RH
AD  - Department of Neurology, University of Pennsylvania, Philadelphia, PA.
LA  - eng
GR  - R01 DC012780/DC/NIDCD NIH HHS/United States
GR  - T32 HD071844/HD/NICHD NIH HHS/United States
PT  - Journal Article
DEP - 20210824
PL  - England
TA  - Aphasiology
JT  - Aphasiology
JID - 8708531
PMC - PMC9855303
MID - NIHMS1733874
OTO - NOTNLM
OT  - Aphasia
OT  - acquired language disorder
OT  - long-term recovery
OT  - neurological rehabilitation
OT  - neuroplasticity
OT  - stroke
COIS- Disclosure statement The authors report no conflict of interest.
EDAT- 2023/01/24 06:00
MHDA- 2023/01/24 06:01
PMCR- 2023/01/20
CRDT- 2023/01/23 04:33
PHST- 2023/01/23 04:33 [entrez]
PHST- 2023/01/24 06:00 [pubmed]
PHST- 2023/01/24 06:01 [medline]
PHST- 2023/01/20 00:00 [pmc-release]
AID - 10.1080/02687038.2021.1966374 [doi]
PST - ppublish
SO  - Aphasiology. 2022;36(11):1351-1372. doi: 10.1080/02687038.2021.1966374. Epub 2021 
      Aug 24.