PMID- 36685497
OWN - NLM
STAT- MEDLINE
DCOM- 20230124
LR  - 20240313
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 13
DP  - 2022
TI  - CCL2: An important cytokine in normal and pathological pregnancies: A review.
PG  - 1053457
LID - 10.3389/fimmu.2022.1053457 [doi]
LID - 1053457
AB  - C-C motif ligand 2 (CCL2), also known as monocytic chemotactic protein 1 (MCP-1), 
      is an integral chemotactic factor which recruits macrophages for the immune 
      response. Together with its receptors (e.g., CCR2, ACKR1, and ACKR2), they exert 
      noticeable influences on various diseases of different systems. At the 
      maternal-fetal interface, CCL2 is detected to be expressed in trophoblasts, 
      decidual tissue, the myometrium, and others. Meanwhile, existing reports have 
      determined a series of physiological regulators of CCL2, which functions in 
      maintaining normal recruitment of immunocytes, tissue remodeling, and 
      angiogenesis. However, abnormal levels of CCL2 have also been reported to be 
      associated with adverse pregnancy outcomes such as spontaneous abortion, 
      preeclampsia and preterm labor. In this review, we concentrate on CCL2 expression 
      at the maternal-fetal interface, as well as its precise regulatory mechanisms and 
      classic signaling pathways, to reveal the multidimensional aspects of CCL2 in 
      pregnancy.
CI  - Copyright (c) 2023 Lin, Shi, Chen, Zheng, Li and Shao.
FAU - Lin, Zhi
AU  - Lin Z
AD  - Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, 
      Fudan University, Shanghai, China.
AD  - Department of Gynecology, Hospital of Obstetrics and Gynecology, Fudan 
      University, Shanghai, China.
FAU - Shi, Jia-Lu
AU  - Shi JL
AD  - Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, 
      Fudan University, Shanghai, China.
FAU - Chen, Min
AU  - Chen M
AD  - Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, 
      Fudan University, Shanghai, China.
FAU - Zheng, Zi-Meng
AU  - Zheng ZM
AD  - Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, 
      Fudan University, Shanghai, China.
FAU - Li, Ming-Qing
AU  - Li MQ
AD  - Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, 
      Fudan University, Shanghai, China.
AD  - National Health Commision (NHC) Key Lab of Reproduction Regulation, Shanghai 
      Institute for Biomedical and Pharmaceutical Technologies, Fudan University, 
      Shanghai, China.
AD  - Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, 
      Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, China.
AD  - Department of Obstetrics and Gynecology, Jinshan Hospital of Fudan University, 
      Shanghai, China.
FAU - Shao, Jun
AU  - Shao J
AD  - Department of Gynecology, Hospital of Obstetrics and Gynecology, Fudan 
      University, Shanghai, China.
AD  - Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, 
      Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230106
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Cytokines)
RN  - 0 (Chemokine CCL2)
RN  - 0 (CCL2 protein, human)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Infant, Newborn
MH  - Humans
MH  - *Cytokines/metabolism
MH  - Decidua
MH  - Trophoblasts/metabolism
MH  - *Abortion, Spontaneous/metabolism
MH  - Chemokine CCL2/metabolism
PMC - PMC9852914
OTO - NOTNLM
OT  - CCL2
OT  - CCR2
OT  - abortion
OT  - decidua
OT  - preeclampsia
OT  - preterm labor
OT  - trophoblast
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/01/24 06:00
MHDA- 2023/01/25 06:00
PMCR- 2022/01/01
CRDT- 2023/01/23 04:36
PHST- 2022/09/25 00:00 [received]
PHST- 2022/12/12 00:00 [accepted]
PHST- 2023/01/23 04:36 [entrez]
PHST- 2023/01/24 06:00 [pubmed]
PHST- 2023/01/25 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2022.1053457 [doi]
PST - epublish
SO  - Front Immunol. 2023 Jan 6;13:1053457. doi: 10.3389/fimmu.2022.1053457. 
      eCollection 2022.