PMID- 36686194
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230918
IS  - 2297-1769 (Print)
IS  - 2297-1769 (Electronic)
IS  - 2297-1769 (Linking)
VI  - 9
DP  - 2022
TI  - First description of interdigital hyperplasia associated with contagious ovine 
      digital dermatitis in two sheep.
PG  - 1028880
LID - 10.3389/fvets.2022.1028880 [doi]
LID - 1028880
AB  - Interdigital hyperplasia (IH) is a fold of fibrous tissue protruding into the 
      interdigital space that rarely occurs in sheep. Interdigital hyperplasia 
      secondary infected with bovine digital dermatitis (BDD) treponemes has been 
      reported in cattle in the course of the increasing spread of classical BDD 
      lesions. In this report, we describe proliferative/ulcerative interdigital 
      lesions associated with contagious ovine digital dermatitis (CODD) treponemes and 
      clinically scored as (IH+CODD), occurring in both hind limbs of a ram and the 
      left hindlimb of a ewe. Both cases exhibited epidermal hyperplasia, parakeratosis 
      and focal-extensive areas of epidermal necrosis with numerous infiltrating 
      neutrophils. Treponema PCR and fluorescence in situ hybridization (FISH) were 
      positive for Treponema phylotype 1 (PT1). In addition, Dichelobacter (D.) nodosus 
      and Porphyromonas (P.) levii were detected in the biopsy by PCR. In three 
      slaughter sheep, without claw lesions, which were kept together with both 
      affected sheep, Treponema spp. were detected neither with PCR nor FISH; the PCRs 
      for D. nodosus and P. levii were also negative. Complete clinical healing 
      occurred in the ewe within 6 weeks after three local applications of a 
      chlortetracycline spray in 2 weeks intervals. This report is the first 
      description of IH+CODD in sheep as demonstrated by a combination of 
      histopathological and molecular analyses.
CI  - Copyright (c) 2023 Alsaaod, Schmid, Zwahlen, Soto, Wildi, Seuberlich and Steiner.
FAU - Alsaaod, Maher
AU  - Alsaaod M
AD  - Clinic for Ruminants, Department of Clinical Veterinary Science, Vetsuisse 
      Faculty, University of Bern, Bern, Switzerland.
FAU - Schmid, Robin Michael
AU  - Schmid RM
AD  - Clinic for Ruminants, Department of Clinical Veterinary Science, Vetsuisse 
      Faculty, University of Bern, Bern, Switzerland.
FAU - Zwahlen, Nathalie
AU  - Zwahlen N
AD  - Clinic for Ruminants, Department of Clinical Veterinary Science, Vetsuisse 
      Faculty, University of Bern, Bern, Switzerland.
FAU - Soto, Sara
AU  - Soto S
AD  - Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, Institute 
      of Animal Pathology, University of Bern, Bern, Switzerland.
FAU - Wildi, Nicole
AU  - Wildi N
AD  - Division of Neurological Sciences, Vetsuisse Faculty Bern, University of Bern, 
      Bern, Switzerland.
FAU - Seuberlich, Torsten
AU  - Seuberlich T
AD  - Division of Neurological Sciences, Vetsuisse Faculty Bern, University of Bern, 
      Bern, Switzerland.
FAU - Steiner, Adrian
AU  - Steiner A
AD  - Clinic for Ruminants, Department of Clinical Veterinary Science, Vetsuisse 
      Faculty, University of Bern, Bern, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20230105
PL  - Switzerland
TA  - Front Vet Sci
JT  - Frontiers in veterinary science
JID - 101666658
PMC - PMC9849560
OTO - NOTNLM
OT  - Treponema spp.
OT  - contagious ovine digital dermatitis (CODD)
OT  - interdigital hyperplasia
OT  - lameness
OT  - sheep
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/01/24 06:00
MHDA- 2023/01/24 06:01
PMCR- 2022/01/01
CRDT- 2023/01/23 04:46
PHST- 2022/08/26 00:00 [received]
PHST- 2022/12/12 00:00 [accepted]
PHST- 2023/01/23 04:46 [entrez]
PHST- 2023/01/24 06:00 [pubmed]
PHST- 2023/01/24 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fvets.2022.1028880 [doi]
PST - epublish
SO  - Front Vet Sci. 2023 Jan 5;9:1028880. doi: 10.3389/fvets.2022.1028880. eCollection 
      2022.