PMID- 36686421
OWN - NLM
STAT- MEDLINE
DCOM- 20230124
LR  - 20240226
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Using hyperhomocysteinemia and body composition to predict the risk of 
      non-alcoholic fatty liver disease in healthcare workers.
PG  - 1063860
LID - 10.3389/fendo.2022.1063860 [doi]
LID - 1063860
AB  - PURPOSE: This study investigated associations between serum homocysteine levels, 
      body composition, and the probability of having nonalcoholic fatty liver disease 
      (NAFLD) in Chinese healthcare workers. PATIENTS AND METHODS: A total of 4028 
      healthcare workers were enrolled in this study, and all underwent a physical 
      examination. Body composition was measured using multifrequency bioelectrical 
      impedance analysis. RESULTS: There were 1507 NAFLD patients (72.26% male, 27.74% 
      female) and 2521 controls (39.83% male, 60.17% female). Body mass index (BMI), 
      waistline, neck-circumference (NC), abdominal visceral fat area (AVFA), total 
      cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol 
      (HDL-C), glucose (Glu), homocysteinemia (hcy) were higher in the NAFLD group than 
      controls. Additionally, the skeletal-muscle was associated with a lower risk of 
      NAFLD, whereas BMI, waistline, NC, hyperhomocysteinemia (HHcy) were associated 
      with a higher risk of NAFLD. The best NC cut-off point for NAFLD was 34.45 cm 
      (sensitivity 83.3% and specificity 83.9%) in women with HHcy, and the best 
      skeletal-muscle content cut-off point for NAFLD was 41.335% (sensitivity 74.2% 
      and specificity 65.6%) in men with HHcy. CONCLUSION: Interactions between 
      skeletal-muscle content, NC, and HHcy may affect the incidence of NAFLD in 
      healthcare workers. This may provide a novel approach for diagnosing NAFLD.
CI  - Copyright (c) 2023 Hao, He, Tao and Wang.
FAU - Hao, Xiaoyan
AU  - Hao X
AD  - Medical examination center, Peking University, Third Hospital, Beijing, China.
FAU - He, Honghai
AU  - He H
AD  - Medical examination center, Peking University, Third Hospital, Beijing, China.
FAU - Tao, Liyuan
AU  - Tao L
AD  - Medical examination center, Peking University, Third Hospital, Beijing, China.
FAU - Wang, Peng
AU  - Wang P
AD  - Medical examination center, Peking University, Third Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230106
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Cholesterol, HDL)
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - *Non-alcoholic Fatty Liver Disease/diagnosis/epidemiology/etiology
MH  - *Hyperhomocysteinemia/complications/diagnosis/epidemiology
MH  - Body Composition
MH  - Body Mass Index
MH  - Cholesterol, HDL
PMC - PMC9852987
OTO - NOTNLM
OT  - abdominal visceral fat area
OT  - homocysteine
OT  - insulin resistance
OT  - neck-circumference
OT  - skeletal-muscle content
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/01/24 06:00
MHDA- 2023/01/25 06:00
PMCR- 2022/01/01
CRDT- 2023/01/23 04:50
PHST- 2022/10/07 00:00 [received]
PHST- 2022/12/19 00:00 [accepted]
PHST- 2023/01/23 04:50 [entrez]
PHST- 2023/01/24 06:00 [pubmed]
PHST- 2023/01/25 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.1063860 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2023 Jan 6;13:1063860. doi: 
      10.3389/fendo.2022.1063860. eCollection 2022.