PMID- 36686506
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 13
DP  - 2022
TI  - Integrative treatment program for the treatment of children with autism spectrum 
      disorder: A prospective observational case series.
PG  - 1017005
LID - 10.3389/fneur.2022.1017005 [doi]
LID - 1017005
AB  - BACKGROUND: In a situation where conventional treatments for autism spectrum 
      disorder (ASD) are labor-intensive and there are concerns about the side effects 
      of conventional medications, a 6-month integrative treatment program, including 
      herbal medicine (HM), Floortime, and sensory enrichment therapy (SET) has been 
      used on children with ASD in Korean medicine clinical settings. METHODS: We 
      observed the treatment responses of 18 children with ASD (66.7% male, mean age 
      3.9 +/- 0.9 years) to the integrative treatment program as part of a prospective, 
      single-center, observational case series. Individualized HMs were administered 
      according to the patient's symptoms, and parents were instructed to perform 
      Floortime and SET with their children at home for 2 h and 20 min a day, 5 days a 
      week, respectively. The Childhood Autism Rating Scale (CARS) and Autism Behavior 
      Checklist (ABC) were used to evaluate the core symptoms of ASD. A linear mixed 
      model for repeated measures was used for analyzing the effect of the program over 
      time, and logistic regression used to explore the predictors of treatment 
      response. RESULTS: The CARS and ABC scores were significantly improved from 34.58 
      +/- 6.27 and 69.28 +/- 15.73 at baseline to 28.56 +/- 6.05 and 39.67 +/- 20.36 after 6 
      months (p < 0.0001, respectively). No serious adverse events (AEs) were reported, 
      and compliance with HM, Floortime, and SET was high at >90%. CONCLUSION: This 
      6-month integrative treatment program appears to be a potentially effective, 
      safe, and feasible option for children with ASD. Low baseline CARS scores may be 
      predictors of higher treatment response.
CI  - Copyright (c) 2023 Lee, Park, Kwon, Hwang and Kim.
FAU - Lee, Boram
AU  - Lee B
AD  - KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, 
      South Korea.
FAU - Park, Serin
AU  - Park S
AD  - Floortime Center Korea, Seoul, South Korea.
FAU - Kwon, Hyun Jeong
AU  - Kwon HJ
AD  - Floortime Center Korea, Seoul, South Korea.
FAU - Hwang, Gwi Seo
AU  - Hwang GS
AD  - College of Korean Medicine, Gachon University, Seongnam, South Korea.
FAU - Kim, Moonju
AU  - Kim M
AD  - I-Tomato Korean Medicine Clinic, Seoul, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20230104
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC9846134
OTO - NOTNLM
OT  - Floortime
OT  - autism spectrum disorder
OT  - case series
OT  - herbal medicine
OT  - integrative medicine
OT  - sensory enrichment therapy
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/01/24 06:00
MHDA- 2023/01/24 06:01
PMCR- 2023/01/04
CRDT- 2023/01/23 04:51
PHST- 2022/08/11 00:00 [received]
PHST- 2022/11/21 00:00 [accepted]
PHST- 2023/01/23 04:51 [entrez]
PHST- 2023/01/24 06:00 [pubmed]
PHST- 2023/01/24 06:01 [medline]
PHST- 2023/01/04 00:00 [pmc-release]
AID - 10.3389/fneur.2022.1017005 [doi]
PST - epublish
SO  - Front Neurol. 2023 Jan 4;13:1017005. doi: 10.3389/fneur.2022.1017005. eCollection 
      2022.