PMID- 36686964
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 2673-6101 (Electronic)
IS  - 2673-6101 (Print)
IS  - 2673-6101 (Linking)
VI  - 3
DP  - 2022
TI  - Cofactors of drug hypersensitivity-A monocenter retrospective analysis.
PG  - 1097977
LID - 10.3389/falgy.2022.1097977 [doi]
LID - 1097977
AB  - BACKGROUND: Drug hypersensitivity reactions (DHRs) are major medical problems 
      that influence the treatment of patients by both under- and overdiagnosis. Still, 
      little is known about the role of predisposing or protecting cofactors of DHR. 
      OBJECTIVE: This study aims to determine drug-specific cofactors in patients with 
      DHR. METHODS: Retrospective file chart analysis of inpatients with suspected DHR 
      in our department between 2015 and 2020 was performed. Descriptive statistics and 
      multiple logistic regression were conducted for the estimation and statistical 
      interference. RESULTS: DHRs were suspected in 393 patients with 678 culprit 
      drugs. In 183 cases, drug hypersensitivities were confirmed, mostly against 
      nonopioid analgesic drugs and antibiotics. Multiple logistic regression analysis 
      identified a positive association of antibiotic hypersensitivity with obesity 
      [odds ratio (OR) 5.75, average marginal effect (AME) +24.4%] and age and a 
      negative association with arterial hypertension, female sex, elevated 
      immunoglobulin E (IgE), and allergic rhinitis. Hypersensitivity to nonopioid 
      analgesics was associated with atopic dermatitis (OR 10.28, AME +28.5%), elevated 
      IgE, and arterial hypertension. CONCLUSIONS: Drug-specific cofactors of DHR 
      include obesity for antibiotics and atopic dermatitis for nonopioid analgesics, 
      the knowledge of which may improve the risk calculation for drug provocation 
      tests.
CI  - (c) 2023 Kuhl, Bergh, Laudes, Szymczak and Heine.
FAU - Kuhl, Johanna
AU  - Kuhl J
AD  - Allergy Division, Department of Dermatology and Allergy, University Hospital 
      Schleswig-Holstein, Kiel, Germany.
FAU - Bergh, Bjorn
AU  - Bergh B
AD  - Institute of Medical Informatics and Statistics, Kiel University and University 
      Hospital Schleswig-Holstein, Kiel, Germany.
FAU - Laudes, Matthias
AU  - Laudes M
AD  - Institute of Diabetes and Clinical Metabolic Research, University Medical Center 
      Schleswig-Holstein, Campus Kiel, Kiel, Germany.
FAU - Szymczak, Silke
AU  - Szymczak S
AD  - Institute of Medical Biometry and Statistics, University of Lubeck and University 
      Medical Center Schleswig-Holstein, Campus Lubeck, Lubeck, Germany.
FAU - Heine, Guido
AU  - Heine G
AD  - Allergy Division, Department of Dermatology and Allergy, University Hospital 
      Schleswig-Holstein, Kiel, Germany.
LA  - eng
PT  - Journal Article
DEP - 20230106
PL  - Switzerland
TA  - Front Allergy
JT  - Frontiers in allergy
JID - 9918227355906676
PMC - PMC9854260
OTO - NOTNLM
OT  - antibiotic
OT  - beta-lactam
OT  - cofactor
OT  - drug allergy
OT  - drug hypersensitivity reaction
OT  - multiple logistic regression
OT  - nonopioid analgesic
COIS- GH reports grants from Deutsche Forschungsgemeinschaft (DFG), during the conduct 
      of the study; and personal fees from Allergopharma, Biotest, Eli Lilly, Sanofi, 
      Abbvie, and Leti outside the submitted work. The remaining authors declare that 
      the research was conducted in the absence of any commercial or financial 
      relationships that could be construed as a potential conflict of interest.
EDAT- 2023/01/24 06:00
MHDA- 2023/01/24 06:01
PMCR- 2023/01/06
CRDT- 2023/01/23 04:56
PHST- 2022/11/14 00:00 [received]
PHST- 2022/12/07 00:00 [accepted]
PHST- 2023/01/23 04:56 [entrez]
PHST- 2023/01/24 06:00 [pubmed]
PHST- 2023/01/24 06:01 [medline]
PHST- 2023/01/06 00:00 [pmc-release]
AID - 10.3389/falgy.2022.1097977 [doi]
PST - epublish
SO  - Front Allergy. 2023 Jan 6;3:1097977. doi: 10.3389/falgy.2022.1097977. eCollection 
      2022.