PMID- 36688158
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230201
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 14
DP  - 2022
TI  - Abnormal functional connectivity of the frontostriatal circuits in type 2 
      diabetes mellitus.
PG  - 1055172
LID - 10.3389/fnagi.2022.1055172 [doi]
LID - 1055172
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated 
      with an increased incidence of cognitive and emotional disorders. Previous 
      studies have indicated that the frontostriatal circuits play a significant role 
      in brain disorders. However, few studies have investigated functional 
      connectivity (FC) abnormalities in the frontostriatal circuits in T2DM. 
      OBJECTIVE: We aimed to investigate the abnormal functional connectivity (FC) of 
      the frontostriatal circuits in patients with T2DM and to explore the relationship 
      between abnormal FC and diabetes-related variables. METHODS: Twenty-seven 
      patients with T2DM were selected as the patient group, and 27 healthy peoples 
      were selected as the healthy controls (HCs). The two groups were matched for age 
      and sex. In addition, all subjects underwent resting-state functional magnetic 
      resonance imaging (rs-fMRI) and neuropsychological evaluation. Seed-based FC 
      analyses were performed by placing six bilateral pairs of seeds within a priori 
      defined subdivisions of the striatum. The functional connection strength of 
      subdivisions of the striatum was compared between the two groups and correlated 
      with each clinical variable. RESULTS: Patients with T2DM showed abnormalities in 
      the FC of the frontostriatal circuits. Our findings show significantly reduced FC 
      between the right caudate nucleus and left precentral gyrus (LPCG) in the 
      patients with T2DM compared to the HCs. The FC between the prefrontal cortex 
      (left inferior frontal gyrus, left frontal pole, right frontal pole, and right 
      middle frontal gyrus) and the right caudate nucleus has a significant positive 
      correlation with fasting blood glucose (FBG). CONCLUSION: The results showed 
      abnormal FC of the frontostriatal circuits in T2DM patients, which might provide 
      a new direction to investigate the neuropathological mechanisms of T2DM.
CI  - Copyright (c) 2023 Fu, Gu, Wang, Xu, Sun, Zhang, Huang, Zhang, Peng and Lin.
FAU - Fu, Yingxia
AU  - Fu Y
AD  - Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, 
      Nanjing University of Chinese Medicine, Nanjing, China.
AD  - Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China.
FAU - Gu, Meiling
AU  - Gu M
AD  - Department of Psychology, Nanjing Normal University, Nanjing, China.
FAU - Wang, Rui
AU  - Wang R
AD  - Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, 
      Nanjing University of Chinese Medicine, Nanjing, China.
AD  - Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China.
FAU - Xu, Juan
AU  - Xu J
AD  - Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, 
      Nanjing University of Chinese Medicine, Nanjing, China.
AD  - Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China.
FAU - Sun, Shenglu
AU  - Sun S
AD  - Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, 
      Nanjing University of Chinese Medicine, Nanjing, China.
AD  - Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China.
FAU - Zhang, Huifeng
AU  - Zhang H
AD  - Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, 
      Nanjing University of Chinese Medicine, Nanjing, China.
AD  - Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China.
FAU - Huang, Dejian
AU  - Huang D
AD  - Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, 
      Nanjing University of Chinese Medicine, Nanjing, China.
AD  - Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China.
FAU - Zhang, Zongjun
AU  - Zhang Z
AD  - Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, 
      Nanjing University of Chinese Medicine, Nanjing, China.
AD  - Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China.
FAU - Peng, Fei
AU  - Peng F
AD  - Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, 
      Nanjing University of Chinese Medicine, Nanjing, China.
AD  - Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China.
FAU - Lin, Pan
AU  - Lin P
AD  - Department of Psychology and Cognition and Human Behavior Key Laboratory of Hunan 
      Province, Hunan Normal University, Hunan, China.
LA  - eng
PT  - Journal Article
DEP - 20230104
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC9846649
OTO - NOTNLM
OT  - frontostriatal circuits
OT  - functional connectivity
OT  - functional magnetic resonance imaging
OT  - resting-state
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/01/24 06:00
MHDA- 2023/01/24 06:01
PMCR- 2022/01/01
CRDT- 2023/01/23 05:12
PHST- 2022/09/27 00:00 [received]
PHST- 2022/12/12 00:00 [accepted]
PHST- 2023/01/23 05:12 [entrez]
PHST- 2023/01/24 06:00 [pubmed]
PHST- 2023/01/24 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2022.1055172 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2023 Jan 4;14:1055172. doi: 10.3389/fnagi.2022.1055172. 
      eCollection 2022.