PMID- 36688194
OWN - NLM
STAT- MEDLINE
DCOM- 20230124
LR  - 20230512
IS  - 1735-3688 (Electronic)
IS  - 0253-0716 (Print)
IS  - 0253-0716 (Linking)
VI  - 48
IP  - 1
DP  - 2023 Jan
TI  - Association of Human Leukocyte Antigen Alleles with Carbamazepine- or 
      Lamotrigine-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in an 
      Iranian Population: A Case-control Study.
PG  - 70-76
LID - 10.30476/IJMS.2022.91192.2241 [doi]
AB  - BACKGROUND: Genetic diversity in human leukocyte antigen (HLA) alleles across 
      populations is a significant risk factor for drug-induced severe cutaneous 
      adverse reactions (SCARs), e.g., carbamazepine (CBZ)- and lamotrigine 
      (LTG)-induced Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis 
      (TEN). The present study aimed to investigate the frequency of different HLA 
      alleles in Iranian patients with CBZ- and LTG-induced SJS/TEN. METHODS: A 
      case-control study was conducted from 2011 to 2018 at various hospitals 
      affiliated with Shiraz University of Medical Sciences (Shiraz, Iran). A total of 
      31 patients receiving anticonvulsant drugs (CZB or LTG) were recruited and 
      divided into two groups. The drug-induced group (n=14) included hospitalized 
      patients due to CBZ- or LTG-induced SJS/TEN. The drug-tolerant group (n=17) 
      included individuals receiving CBZ or LTG for at least three months with no 
      adverse effects. In addition, 46 healthy individuals (control group) were 
      recruited. The frequency of HLA-A, -B, and -DRB1 alleles in patients with CZB- or 
      LTG-induced SJS/TEN was investigated. HLA typing was performed using the 
      allele-specific polymerase chain reaction method. The Chi square test and 
      Fisher's exact test were used to determine a potential association between 
      SJS/TEN and HLA alleles. P<0.05 was considered statistically significant. 
      RESULTS: CBZ- or LTG-induced SJS/TEN was not significantly associated with HLA 
      alleles. However, HLA-DRB1*01 showed a significantly higher frequency in patients 
      with CBZ-induced SJS/TEN than the CBZ-tolerant patients (30% vs. 9%, P=0.07). 
      CONCLUSION: Overall, no significant association was found between CBZ- or 
      LTG-induced SJS/TEN and HLA alleles. Further large-scale studies are required to 
      substantiate our findings.
CI  - Copyright: (c) Iranian Journal of Medical Sciences.
FAU - Dastgheib, Ladan
AU  - Dastgheib L
AD  - Molecular Dermatology Research Center, Department of Dermatology, Shiraz 
      University of Medical Sciences, Shiraz, Iran.
FAU - Rostami, Farima
AU  - Rostami F
AD  - Student Research Committee, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Gharesi-Fard, Behrouz
AU  - Gharesi-Fard B
AD  - Department of Immunology, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Asadi-Pooya, Ali Akbar
AU  - Asadi-Pooya AA
AD  - Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
AD  - Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas 
      Jefferson University, Philadelphia, PA, USA.
FAU - Namjoo, Saba
AU  - Namjoo S
AD  - Blood Transfusion Research Center, High Institute for Education and Research in 
      Transfusion Medicine, Tehran, Iran.
FAU - Tahmasebi, Foroozan
AU  - Tahmasebi F
AD  - Department of Immunology, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Hadibarhaghtalab, Maryam
AU  - Hadibarhaghtalab M
AD  - Molecular Dermatology Research Center, Department of Dermatology, Shiraz 
      University of Medical Sciences, Shiraz, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Med Sci
JT  - Iranian journal of medical sciences
JID - 8104374
RN  - 0 (Anticonvulsants)
RN  - U3H27498KS (Lamotrigine)
RN  - 0 (HLA-B Antigens)
RN  - 33CM23913M (Carbamazepine)
RN  - 12794-10-4 (Benzodiazepines)
SB  - IM
MH  - Humans
MH  - *Anticonvulsants/adverse effects
MH  - Lamotrigine/adverse effects
MH  - Iran
MH  - *Stevens-Johnson Syndrome/genetics
MH  - Alleles
MH  - Case-Control Studies
MH  - HLA-B Antigens/genetics
MH  - Asian People
MH  - Carbamazepine/adverse effects
MH  - Benzodiazepines
PMC - PMC9843459
OTO - NOTNLM
OT  - Anticonvulsants
OT  - Histocompatibility testing
OT  - Stevens-Johnson syndrome
COIS- None declared.
EDAT- 2023/01/24 06:00
MHDA- 2023/01/25 06:00
PMCR- 2023/01/01
CRDT- 2023/01/23 05:13
PHST- 2021/05/26 00:00 [received]
PHST- 2021/11/21 00:00 [revised]
PHST- 2022/01/30 00:00 [accepted]
PHST- 2023/01/23 05:13 [entrez]
PHST- 2023/01/24 06:00 [pubmed]
PHST- 2023/01/25 06:00 [medline]
PHST- 2023/01/01 00:00 [pmc-release]
AID - IJMS-48-1 [pii]
AID - 10.30476/IJMS.2022.91192.2241 [doi]
PST - ppublish
SO  - Iran J Med Sci. 2023 Jan;48(1):70-76. doi: 10.30476/IJMS.2022.91192.2241.