PMID- 36689072
OWN - NLM
STAT- MEDLINE
DCOM- 20230405
LR  - 20240124
IS  - 2212-5469 (Electronic)
IS  - 1738-2696 (Print)
IS  - 1738-2696 (Linking)
VI  - 20
IP  - 2
DP  - 2023 Apr
TI  - Silica-Based Advanced Nanoparticles For Treating Ischemic Disease.
PG  - 177-198
LID - 10.1007/s13770-022-00510-z [doi]
AB  - Recently, various attempts have been made to apply diverse types of nanoparticles 
      in biotechnology. Silica nanoparticles (SNPs) have been highlighted and studied 
      for their selective accumulation in diseased parts, strong physical and chemical 
      stability, and low cytotoxicity. SNPs, in particular, are very suitable for use 
      in drug delivery and bioimaging, and have been sought as a treatment for ischemic 
      diseases. In addition, mesoporous silica nanoparticles have been confirmed to 
      efficiently deliver various types of drugs owing to their porous structure. 
      Moreover, there have been innovative attempts to treat ischemic diseases using 
      SNPs, which utilize the effects of Si ions on cells to improve cell viability, 
      migration enhancement, and phenotype modulation. Recently, external 
      stimulus-responsive treatments that control the movement of magnetic SNPs using 
      external magnetic fields have been studied. This review addresses several 
      original attempts to treat ischemic diseases using SNPs, including particle 
      synthesis methods, and presents perspectives on future research directions.
CI  - (c) 2023. Korean Tissue Engineering and Regenerative Medicine Society.
FAU - Kudaibergen, Dauletkerey
AU  - Kudaibergen D
AD  - Department of Civil and Environmental Engineering, Pusan National University, 
      Busan, 46241, Republic of Korea.
FAU - Park, Hyun Su
AU  - Park HS
AD  - School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic 
      of Korea.
FAU - Park, Jinwook
AU  - Park J
AD  - Department of Civil and Environmental Engineering, Pusan National University, 
      Busan, 46241, Republic of Korea.
FAU - Im, Gwang-Bum
AU  - Im GB
AD  - School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic 
      of Korea.
FAU - Lee, Ju-Ro
AU  - Lee JR
AD  - Center for Biomaterials, Biomedical Research Institute, Korea Institute of 
      Science and Technology, Seoungbuk-Gu, Seoul, 02792, Republic of Korea.
FAU - Joung, Yoon Ki
AU  - Joung YK
AD  - Center for Biomaterials, Biomedical Research Institute, Korea Institute of 
      Science and Technology, Seoungbuk-Gu, Seoul, 02792, Republic of Korea.
FAU - Bhang, Suk Ho
AU  - Bhang SH
AD  - School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic 
      of Korea. sukhobhang@skku.edu.
FAU - Kim, Jae-Hyuk
AU  - Kim JH
AD  - Department of Civil and Environmental Engineering, Pusan National University, 
      Busan, 46241, Republic of Korea. jaehyuk.kim@pusan.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230123
PL  - Korea (South)
TA  - Tissue Eng Regen Med
JT  - Tissue engineering and regenerative medicine
JID - 101699923
RN  - 0 (Drug Carriers)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - *Drug Carriers/chemistry
MH  - Silicon Dioxide/chemistry
MH  - Drug Delivery Systems/methods
MH  - *Nanoparticles/chemistry
MH  - Porosity
PMC - PMC10070585
OTO - NOTNLM
OT  - Bioimaging
OT  - Drug delivery system
OT  - Ischemic disease treatment
OT  - Silica based magnetic nanoparticle
OT  - Silica nanoparticle
COIS- The authors declare no conflict of interest.
EDAT- 2023/01/24 06:00
MHDA- 2023/04/05 06:42
PMCR- 2024/01/23
CRDT- 2023/01/23 11:18
PHST- 2022/08/08 00:00 [received]
PHST- 2022/11/16 00:00 [accepted]
PHST- 2022/10/31 00:00 [revised]
PHST- 2023/04/05 06:42 [medline]
PHST- 2023/01/24 06:00 [pubmed]
PHST- 2023/01/23 11:18 [entrez]
PHST- 2024/01/23 00:00 [pmc-release]
AID - 10.1007/s13770-022-00510-z [pii]
AID - 510 [pii]
AID - 10.1007/s13770-022-00510-z [doi]
PST - ppublish
SO  - Tissue Eng Regen Med. 2023 Apr;20(2):177-198. doi: 10.1007/s13770-022-00510-z. 
      Epub 2023 Jan 23.