PMID- 36689469
OWN - NLM
STAT- MEDLINE
DCOM- 20230203
LR  - 20230203
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 15
IP  - 4
DP  - 2023 Feb 1
TI  - Two-Dimensional Nitrogen-Doped Carbon Nanosheets Derived from g-C(3)N(4) /ZIF-8 
      for Solid-Phase Microextraction in Exhalation of Esophageal Cancer Patients.
PG  - 5990-5997
LID - 10.1021/acsami.2c21858 [doi]
AB  - Here, two-dimensional (2D) nitrogen-doped carbon nanosheets (CNSs) were prepared 
      through carbonizing MOFs (ZIF-8) in-situ grown using graphitic carbon nitride 
      (g-C(3)N(4)) as a template. The developed ZIF-8 CNS was then used as solid-phase 
      microextraction (SPME) fiber coating for beneficiation of five biomarkers in 
      exhalation of patients with esophageal cancer and in gas chromatography-mass 
      spectrometry (GC-MS) for determination. The ZIF-8 CNS fiber exhibits satisfactory 
      enrichment factors (3490-5631), wide linearity (5-1000 mug L(-1)), and low 
      detection limits (0.26-0.96 mug L(-1)). The relative standard deviations (RSDs) 
      for six replicate extractions of the same ZIF-8 CNS fiber were between 2.0-3.9% 
      (intra-day) and 2.8-5.2% (inter-day). The reproducibility of three fibers 
      prepared by the same approach was in the range 6.8-12.3% (RSD). The developed 
      ZIF-8 CNS fiber can persist in 120 SPME cycles with no prominent loss of 
      extraction efficiency and precision. The high enrichment factors of the 2D ZIF-8 
      CNS coatings are attributed to the high specific surface area, ultrathin 
      thickness, and nano-pore or interlayer channels; moreover, nitrogen doping also 
      endows the pi system with a strong electron absorption ability, which will enhance 
      the pi-pi interaction between the ZIF-8 CNS and the aromatic ring. Ultimately, the 
      self-made ZIF-8 CNS-coated SPME fiber was applied to the analysis of exhaled 
      breath samples. The recoveries of spiked analytes are between 84 and 105%.
FAU - Hao, Qi-Long
AU  - Hao QL
AD  - Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of 
      Education, Key Laboratory of Analytical Science and Technology of Hebei Province, 
      College of Chemistry and Environmental Science, Hebei University, Baoding 071002, 
      China.
FAU - Yu, Li-Qing
AU  - Yu LQ
AUID- ORCID: 0000-0003-1885-9967
AD  - Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of 
      Education, Key Laboratory of Analytical Science and Technology of Hebei Province, 
      College of Chemistry and Environmental Science, Hebei University, Baoding 071002, 
      China.
FAU - Yang, Xiao-Qin
AU  - Yang XQ
AD  - Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of 
      Education, Key Laboratory of Analytical Science and Technology of Hebei Province, 
      College of Chemistry and Environmental Science, Hebei University, Baoding 071002, 
      China.
FAU - Xu, Rui-Ting
AU  - Xu RT
AD  - Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of 
      Education, Key Laboratory of Analytical Science and Technology of Hebei Province, 
      College of Chemistry and Environmental Science, Hebei University, Baoding 071002, 
      China.
FAU - Lv, Yun-Kai
AU  - Lv YK
AD  - Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of 
      Education, Key Laboratory of Analytical Science and Technology of Hebei Province, 
      College of Chemistry and Environmental Science, Hebei University, Baoding 071002, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20230123
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 7440-44-0 (Carbon)
RN  - N762921K75 (Nitrogen)
SB  - IM
MH  - Humans
MH  - *Carbon/chemistry
MH  - Nitrogen
MH  - Solid Phase Microextraction/methods
MH  - Exhalation
MH  - Reproducibility of Results
MH  - *Esophageal Neoplasms
OTO - NOTNLM
OT  - carbon nanosheets
OT  - esophageal cancer
OT  - exhaled breath
OT  - nitrogen-doped
OT  - solid-phase microextraction
EDAT- 2023/01/24 06:00
MHDA- 2023/02/04 06:00
CRDT- 2023/01/23 13:43
PHST- 2023/01/24 06:00 [pubmed]
PHST- 2023/02/04 06:00 [medline]
PHST- 2023/01/23 13:43 [entrez]
AID - 10.1021/acsami.2c21858 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2023 Feb 1;15(4):5990-5997. doi: 
      10.1021/acsami.2c21858. Epub 2023 Jan 23.