PMID- 3668982
OWN - NLM
STAT- MEDLINE
DCOM- 19871123
LR  - 20071114
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 14
IP  - 4
DP  - 1987 Aug
TI  - IgM rheumatoid factor in Lyme disease: correlation with disease activity, total 
      serum IgM, and IgM antibody to Borrelia burgdorferi.
PG  - 772-6
AB  - We tested the sera of 50 patients with Lyme disease for IgM-rheumatoid factor 
      (IgM-RF) using a sensitive ELISA. Levels of IgM-RF greater than 3 SD above the 
      mean of normal subjects were found in 2 of 15 patients with erythema chronicum 
      migrans, 7 of 10 with neurologic abnormalities, and 7 of 25 with Lyme arthritis 
      (p = 0.038). Only 2 of these sera were positive by latex agglutination. In 
      contrast, none of the 23 control patients with osteoarthritis, ankylosing 
      spondylitis, or Reiter's syndrome had positive tests. The levels of IgM-RF 
      correlated with disease activity (p = 0.002), total serum IgM levels (p = 0.002), 
      and specific IgM antibody titers to Borrelia burgdorferi (p = 0.006). IgM-RF 
      reactivity was absorbed with heat aggregated IgG (HAGG), but the titer of 
      specific IgM antibody was insignificantly affected by this procedure. Thus, small 
      amounts of RF are produced at certain times in many patients with Lyme disease, 
      and IgM-RF production appears to be linked to the specific IgM response.
FAU - Kujala, G A
AU  - Kujala GA
AD  - Department of Internal Medicine, University of Virginia School of Medicine, 
      Charlottesville.
FAU - Steere, A C
AU  - Steere AC
FAU - Davis, J S 4th
AU  - Davis JS 4th
LA  - eng
GR  - 5T32-AM07156/AM/NIADDK NIH HHS/United States
GR  - AM07107/AM/NIADDK NIH HHS/United States
GR  - AM20358/AM/NIADDK NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Immunoglobulin M)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antibodies, Bacterial/*analysis
MH  - Borrelia/*immunology
MH  - Child
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Immunoglobulin M/*analysis
MH  - Lyme Disease/*immunology
MH  - Male
MH  - Middle Aged
MH  - Rheumatoid Factor/*analysis
EDAT- 1987/08/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1987/08/01 00:00
PHST- 1987/08/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1987/08/01 00:00 [entrez]
PST - ppublish
SO  - J Rheumatol. 1987 Aug;14(4):772-6.