PMID- 36690051
OWN - NLM
STAT- MEDLINE
DCOM- 20230314
LR  - 20230314
IS  - 1873-2933 (Electronic)
IS  - 0009-9120 (Linking)
VI  - 114
DP  - 2023 Apr
TI  - Chinese pediatric and adolescent reference intervals of vitamin E based on 
      real-world physical examination data.
PG  - 18-23
LID - S0009-9120(23)00008-5 [pii]
LID - 10.1016/j.clinbiochem.2023.01.008 [doi]
AB  - OBJECTIVES: To establish the reference interval (RI) of vitamin E for Chinese 
      children and adolescents. MATERIALS AND METHODS: Serum tocopherol samples were 
      examined using high performance liquid chromatography in third-party clinical 
      laboratory institutions. Using real-world data from multi-center clinical 
      laboratory institutions in China, the distribution parameters of vitamin E levels 
      were described and the RI was calculated using three algorithms. RESULTS: A total 
      of 756,766 cases were included in the analysis, including 435,561 males and 
      321,205 females. The median of vitamin E in infants younger than 4 years of age 
      initially increased but subsequently decreased; while its levels in children 
      between 4 and 11 years of age remained relatively stable despite progressing in 
      age (approximately 7.4-7.8 mg/L). After the start of puberty, the difference, 
      relative to sex, gradually became apparent, and the median vitamin E levels in 
      females was higher than in males. The differences of vitamin E levels between 
      different regions and samples in different seasons had no clinical significance. 
      The RI of vitamin E for children aged 0-18 years in China was 4.5-11.1 mg/L based 
      on expectation-maximization algorithm. The RI established by the Hoffmann method 
      was 4.6-12.8 mg/L. CONCLUSION: The age- and sex-specific RIs of vitamin E were 
      established by an indirect approach. The RIs established by EM algorithms could 
      be used as an alternative to establish RIs based on real-world data.
CI  - Copyright (c) 2023 The Canadian Society of Clinical Chemists. Published by Elsevier 
      Inc. All rights reserved.
FAU - Wang, Chen
AU  - Wang C
AD  - Center for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's 
      Hospital, Capital Medical University, National Center for Children Health, 
      Beijing, China.
FAU - Feng, Jingjing
AU  - Feng J
AD  - Department of Nursing Administration and Rehabilitation Research, National 
      Institute of Hospital Administration, Beijing, China.
FAU - Peng, Xiaoxia
AU  - Peng X
AD  - Center for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's 
      Hospital, Capital Medical University, National Center for Children Health, 
      Beijing, China.
FAU - Liu, Xiaohang
AU  - Liu X
AD  - Center for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's 
      Hospital, Capital Medical University, National Center for Children Health, 
      Beijing, China.
FAU - Yan, Ruohua
AU  - Yan R
AD  - Center for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's 
      Hospital, Capital Medical University, National Center for Children Health, 
      Beijing, China.
FAU - Peng, Yaguang
AU  - Peng Y
AD  - Center for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's 
      Hospital, Capital Medical University, National Center for Children Health, 
      Beijing, China. Electronic address: plwumi@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20230121
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 1406-18-4 (Vitamin E)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Male
MH  - China
MH  - *East Asian People
MH  - Reference Values
MH  - *Vitamin E/blood
OTO - NOTNLM
OT  - Indirect approach
OT  - Real world data
OT  - Reference interval
OT  - Vitamin E
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/01/24 06:00
MHDA- 2023/03/15 06:00
CRDT- 2023/01/23 19:22
PHST- 2022/11/03 00:00 [received]
PHST- 2023/01/11 00:00 [revised]
PHST- 2023/01/17 00:00 [accepted]
PHST- 2023/01/24 06:00 [pubmed]
PHST- 2023/03/15 06:00 [medline]
PHST- 2023/01/23 19:22 [entrez]
AID - S0009-9120(23)00008-5 [pii]
AID - 10.1016/j.clinbiochem.2023.01.008 [doi]
PST - ppublish
SO  - Clin Biochem. 2023 Apr;114:18-23. doi: 10.1016/j.clinbiochem.2023.01.008. Epub 
      2023 Jan 21.