PMID- 36690893
OWN - NLM
STAT- MEDLINE
DCOM- 20230505
LR  - 20230510
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 37
IP  - 5
DP  - 2023 May
TI  - Comparison of endoscopic full-thickness resection and ligation-assisted 
      endoscopic full-thickness resection for small (</= 1.5 cm) gastric subepithelial 
      tumors originating from muscularis propria.
PG  - 3796-3806
LID - 10.1007/s00464-023-09881-3 [doi]
AB  - BACKGROUND: In the treatment of small gastric subepithelial tumors originating 
      from muscularis propria (SET-MPs), endoscopic full-thickness resection (EFTR) has 
      been an effective procedure and ligation-assisted EFTR (EFTR-L) seems a feasible 
      and promising operation. We aimed to compare the therapeutic outcomes of EFTR-L 
      and EFTR to evaluate effect and safety of either method in the treatment of small 
      (</= 1.5 cm) gastric SET-MPs. METHODS: Between January 2018 to May 2022, we 
      retrospectively enrolled a total of 119 patients with gastric SET-MPs treated by 
      EFTR-L (79 patients) or EFTR (40 patients) at Xiangya Hospital Central South 
      University. Clinical characteristics, operation efficacy, adverse events (AEs), 
      and operation cost were compared between the 2 groups. Univariate and multiple 
      logistic and linear regressions were applied to analyze the therapeutic outcomes 
      of the procedure, and covariates were adjusted in the multiple analysis. RESULTS: 
      The operation time of EFTR-L group (16.34 +/- 5.75 min) was significantly shorter 
      than EFTR group (51.23 +/- 21.21 min, P < 0.001), and the difference remained 
      significant after adjusting the covariates (adjusted mean difference, 30.56; 95% 
      confidence interval, 25.65-35.47; P < 0.001). The operation cost of EFTR-L group 
      was lower than EFTR group (1268.52 +/- 457.22 vs 1643.18 +/- 295.08 $; P < 0.001). 
      The complete resection rate of the EFTR-L group was 98.72% and of the EFTR group 
      100%. The incidence of abdominal pain in the EFTR-L group (5.06%) was lower than 
      in the EFTR group (27.50%, P = 0.008). A patient in the EFTR group underwent 
      severe pneumoperitoneum and received abdominocentesis during operation. One case 
      of peritonitis occurred in the EFTR-L group but recovered from intensified 
      antibiotic therapy. No delayed blood or perforation occurred. CONCLUSIONS: 
      Compared to EFTR, EFTR-L might be a feasible procedure for small (</= 1.5 cm) 
      gastric SET-MPs due to the acceptable efficacy, shorter operation time, and lower 
      cost.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Gu, Lei
AU  - Gu L
AUID- ORCID: 0000-0002-6547-5459
AD  - Department of Gastroenterology, Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Wu, Yu
AU  - Wu Y
AD  - Department of Gastroenterology, Xiangya Hospital, Central South University, 
      Changsha, Hunan, China. wy22xy@163.com.
FAU - Yi, Jun
AU  - Yi J
AD  - Department of Gastroenterology, Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Ouyang, Miao
AU  - Ouyang M
AD  - Department of Gastroenterology, Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Liu, Xiaowei
AU  - Liu X
AUID- ORCID: 0000-0002-1193-4277
AD  - Department of Gastroenterology, Xiangya Hospital, Central South University, 
      Changsha, Hunan, China. liuxw@csu.edu.cn.
AD  - Hunan International Scientific and Technological Cooperation Base of Artificial 
      Intelligence Computer Aided Diagnosis and Treatment for Digestive Disease 
      (2020CB1004), Changsha, Hunan, China. liuxw@csu.edu.cn.
AD  - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 
      Central South University, Changsha, Hunan, China. liuxw@csu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230123
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
SB  - IM
MH  - Humans
MH  - Gastroscopy/methods
MH  - Retrospective Studies
MH  - *Stomach Neoplasms/surgery/pathology
MH  - *Endoscopic Mucosal Resection/adverse effects/methods
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Endoscopic full-thickness resection
OT  - Gastric subepithelial tumors
OT  - Ligation
EDAT- 2023/01/24 06:00
MHDA- 2023/05/05 06:42
CRDT- 2023/01/23 23:27
PHST- 2022/10/30 00:00 [received]
PHST- 2023/01/08 00:00 [accepted]
PHST- 2023/05/05 06:42 [medline]
PHST- 2023/01/24 06:00 [pubmed]
PHST- 2023/01/23 23:27 [entrez]
AID - 10.1007/s00464-023-09881-3 [pii]
AID - 10.1007/s00464-023-09881-3 [doi]
PST - ppublish
SO  - Surg Endosc. 2023 May;37(5):3796-3806. doi: 10.1007/s00464-023-09881-3. Epub 2023 
      Jan 23.