PMID- 36691957
OWN - NLM
STAT- MEDLINE
DCOM- 20230224
LR  - 20230224
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 14
IP  - 4
DP  - 2023 Feb 21
TI  - Onchidium struma polysaccharides exhibit hypoglycemic activity and modulate the 
      gut microbiota in mice with type 2 diabetes mellitus.
PG  - 1937-1951
LID - 10.1039/d2fo02450k [doi]
AB  - Onchidium struma polysaccharides (OsPs) are natural biologically active 
      compounds, and our previous work showed that they can inhibit the activity of 
      alpha-glucosidase in vitro, showing potential hypoglycemic activity. However, the 
      effects of OsPs on type 2 diabetes mellitus (T2DM) in vivo remain unknown. Thus, 
      the anti-diabetic activity of OsPs was evaluated in the present study in diabetic 
      mice. The results showed that OsPs can significantly ameliorate the features of 
      T2DM in mice by improving the levels of fasting blood glucose (FBG), oral glucose 
      tolerance test (OGTT), and pro-inflammatory factors, and ameliorating insulin 
      resistance. Furthermore, OsPs can significantly improve biochemical indicators, 
      decrease the contents of total cholesterol (TC) and triglyceride (TG), and reduce 
      lipid accumulation in the liver. The possible mechanism of the prevention and 
      treatment of T2DM by OsPs may involve the phosphoinositide 3-kinase 
      (PI3K)/protein kinase B (AKT-1) signaling pathway. OsPs can regulate the 
      dysbiosis of gut microbiota and reverse the abundance of Lactobacillus in mice 
      with T2DM. Moreover, OsPs significantly increased the concentration of 
      short-chain fatty acids (SCFAs) in mice with T2DM. Our results indicate that OsPs 
      can be used as a novel food supplement for the prevention and treatment of T2DM.
FAU - Zhao, Yunfeng
AU  - Zhao Y
AD  - School of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng 
      224051, China. ycit549638894@outlook.com.
FAU - Song, Peilin
AU  - Song P
AD  - School of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng 
      224051, China. ycit549638894@outlook.com.
AD  - Public Analysis Department, Pharmaceutical Research Institute of Jumpcan 
      Pharmaceutical Group Co., Ltd, Taizhou, Jiangsu 225300, China.
FAU - Yin, Shuai
AU  - Yin S
AD  - School of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng 
      224051, China. ycit549638894@outlook.com.
FAU - Fan, Tianyong
AU  - Fan T
AD  - School of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng 
      224051, China. ycit549638894@outlook.com.
FAU - Li, Fengwei
AU  - Li F
AD  - School of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng 
      224051, China. ycit549638894@outlook.com.
FAU - Ge, Xiaodong
AU  - Ge X
AUID- ORCID: 0000-0002-3300-6711
AD  - School of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng 
      224051, China. ycit549638894@outlook.com.
FAU - Liu, Tingting
AU  - Liu T
AD  - Clinical Pharmacy Department, Yancheng Second People's Hospital, Yancheng 224051, 
      China.
FAU - Xu, Wei
AU  - Xu W
AUID- ORCID: 0000-0002-0551-1251
AD  - School of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng 
      224051, China. ycit549638894@outlook.com.
AD  - Jiangsu Key Laboratory of Biochemistry and Biotechnology of Marine Wetland, 
      Yancheng Institute of Technology, Yancheng 224051, China.
FAU - Xu, Su
AU  - Xu S
AD  - Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese 
      Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 
      224001, China. xstcm81@yeah.net.
FAU - Chen, Ligen
AU  - Chen L
AUID- ORCID: 0000-0002-1460-3457
AD  - School of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng 
      224051, China. ycit549638894@outlook.com.
AD  - Jiangsu Key Laboratory of Biochemistry and Biotechnology of Marine Wetland, 
      Yancheng Institute of Technology, Yancheng 224051, China.
LA  - eng
PT  - Journal Article
DEP - 20230221
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Hypoglycemic Agents)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - 0 (Polysaccharides)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Mice
MH  - Animals
MH  - Hypoglycemic Agents/pharmacology
MH  - *Diabetes Mellitus, Type 2/metabolism
MH  - *Diabetes Mellitus, Experimental/metabolism
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - *Gastrointestinal Microbiome
MH  - Polysaccharides/pharmacology
MH  - Blood Glucose/metabolism
EDAT- 2023/01/25 06:00
MHDA- 2023/02/25 06:00
CRDT- 2023/01/24 05:33
PHST- 2023/01/25 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2023/01/24 05:33 [entrez]
AID - 10.1039/d2fo02450k [doi]
PST - epublish
SO  - Food Funct. 2023 Feb 21;14(4):1937-1951. doi: 10.1039/d2fo02450k.